29 research outputs found
SERUM LUTEINIZING HORMONE AND FOLLICLE STIMULATING HORMONE IN NORMAL CHILDREN AND PATIENTS WITH VARIOUS CLINICAL DISORDERS
Serum concentrations of luteinizing hormone (LH) and follicle stimulating hormone (FSH) were determined in 329 normal children and 185 individuals with endocrinological abnormalities or variations of development. A significant increase of gonadotrophins is noted at the onset of puberty among the boys and at menarche for girls. The values are compared with serum concentrations of LH and FSH in children with abnormalities of sexual development, pituitary malfunction as well as other clinical abnormalities. Comparable levels for age and stage of development were found for premature thelarche, premature adrenarche, cryptorchidism, male pseudohermaphroditism and pubertal gynaecomastia. Hypogonadal individuals (Klinefelter's and Turner's syndrome, pure ovarian dysgenesis and testicular dysgenesis) have markedly elevated values while those with pituitary hypofunction had low values. Patients with sexual prococity tended to have elevated concentrations.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73601/1/j.1365-2265.1973.tb00427.x.pd
The Practice of Product Testing in the New Product Development Process: The Role of Model‐Based Approaches
p53 expression in dyskeratosis congenita: a marker for oral premalignancy?
As p53 expression has been associated with malignant disease its presence was assessed in biopsy specimens from dorsal lingual hyperkeratosis, taken over a five year period. p53 expression, using CM1, was assessed using a standard immunoperoxidase technique. p53 was not identified in the first biopsy specimen in 1986 but was identified in all subsequent ones. Only in the latest biopsy specimen was there evidence for dysplasia in haematoxylin and eosin stained sections. It is suggested that p53 expression may be a reliable marker for predicting premalignant change in keratoses occurring in dyskeratosis congenita
Adoption, use and perception of Australian acacias around the world
Aim To examine the different uses and perceptions of introduced Australian acacias (wattles; Acacia subgenus Phyllodineae) by rural households and communities. Location Eighteen landscape-scale case studies around the world, in Vietnam, India, Réunion, Madagascar, South Africa, Congo, Niger, Ethiopia, Israel, France, Portugal, Brazil, Chile, Dominican Republic and Hawai'i. Methods Qualitative comparison of case studies, based on questionnaire sent to network of acacia researchers. Information based on individual knowledge of local experts, published and unpublished sources. Results We propose a conceptual model to explain current uses and perceptions of introduced acacias. It highlights historically and geographically contingent processes, including economic development, environmental discourses, political context, and local or regional needs. Four main groupings of case studies were united by similar patterns: (1) poor communities benefiting from targeted agroforestry projects; (2) places where residents, generally poor, take advantage of a valuable resource already present in their landscape via plantation and/or invasion; (3) regions of small and mid-scale tree farmers participating in the forestry industry; and (4) a number of high-income communities dealing with the legacies of former or niche use of introduced acacia in a context of increased concern over biodiversity and ecosystem services. Main conclusions Economic conditions play a key role shaping acacia use. Poorer communities rely strongly on acacias (often in, or escaped from, formal plantations) for household needs and, sometimes, for income. Middle-income regions more typically host private farm investments in acacia woodlots for commercialization. Efforts at control of invasive acacias must take care to not adversely impact poor dependent communities. © 2011 Blackwell Publishing Ltd.Articl
Slave sugar boycotts, female activism and the domestic base of British anti‐slavery culture 1
Variety is the Spice of Life: Combining Soft and Hard OR/MS Methods
Some observers have expressed concern over the state of the OR/MS profession, especially as to its
failure to tackle complex, messy problems. One response has been to develop various ``soft'' methods
(also called ``problem structuring methods'') that focus on the human and political aspects of OR/MS
interventions. Recent work, both theoretical and practitioner-based, involves the combination of several
methods in a particular project (multimethod). Often the combination includes both hard (quantitative)
and soft (qualitative) approaches. This paper illustrates the utility of soft methods, and in particular
their combination, with recently published case studies. It then proposes an approach to the process of
combining methods, including several frameworks and techniques to assist in selecting and linking
di?erent methods. Finally, it discusses future research in this fiel