The X-ray Binary Analogy to the First AGN QPO

The Narrow Line Seyfert 1 galaxy REJ1034+396 is so far unique amongst AGN in showing a Quasi-periodic oscillation (QPO) in its variability power spectrum. There are multiple types of QPO seen in black hole binary (BHB) systems, so we need to identify which BHB QPO corresponds to the one seen in the AGN. A key hint is the `hot disc dominated' energy spectrum of REJ1034+396 which is sufficiently unusual that it suggests a mildly super-Eddington flow, also favoured by the most recent mass estimates for the AGN. This suggests the 67Hz QPO seen occasionally in the mildly super-Eddington BHB GRS 1915+105 as the most likely counterpart, assuming mass scaling of the QPO frequency. This is supported by the fact that these data from GRS 1915+105 have an energy spectrum which is also dominated by a `hot disc' component. Here we show that the underlying broad band power spectral shape and normalisation are also similar, providing further consistency checks for this identification. Thus the AGN QPO adds to the growing evidence for a simple mass scaling of the accretion flow properties between stellar and supermassive black holes.Comment: 9 pages, 12 figures, to be published in MNRA

Technique for extending the frequency range of digital dividers

A technique for extending the frequency range of a presettable digital divider is described. The conventional digital divider consists of several counter stages with the count of each stage compared to a preselected number. When the counts for all stages are equal to the preselected numbers, an output pulse is generated and all stages are reset. For high input frequencies, the least significant stage of the divider has to be reset in a very short time. This limits the frequency that can be handled by the conventional digital divider. This invention provides a technique in which the second least significant and higher stages are reset and the least significant stage is permitted to free-run. Hence, the time in which the reset operation can be performed is increased thereby extending the frequency range of the divider

Generic education for specialist information professionals

Debate concerning specialist and generalist education for law librarianship is reviewed

The effects of centrifuge radius on the performance of entry tasks

Effects of centrifuge radius on entry task performance - discrete response task, tracking task, and transfer of training effect

Escaping the Smoke

This poem, inspired by the author\u27s experience with his psychiatry rotation illustrates the palpable symptoms felt by patients suffering with anxiety. The form, pattern, and word choices were purposefully selected to mirror the difficulty and unpredictable nature of the disease

Exploiting Synergy Between Ontologies and Recommender Systems

Recommender systems learn about user preferences over time, automatically finding things of similar interest. This reduces the burden of creating explicit queries. Recommender systems do, however, suffer from cold-start problems where no initial information is available early on upon which to base recommendations. Semantic knowledge structures, such as ontologies, can provide valuable domain knowledge and user information. However, acquiring such knowledge and keeping it up to date is not a trivial task and user interests are particularly difficult to acquire and maintain. This paper investigates the synergy between a web-based research paper recommender system and an ontology containing information automatically extracted from departmental databases available on the web. The ontology is used to address the recommender systems cold-start problem. The recommender system addresses the ontology's interest-acquisition problem. An empirical evaluation of this approach is conducted and the performance of the integrated systems measured

Development of the CHARIOT Research Register for the Prevention of Alzheimer’s Dementia and Other Late Onset Neurodegenerative Diseases

Identifying cognitively healthy people at high risk of developing dementia is an ever-increasing focus. These individuals are essential for inclusion in observational studies into the natural history of the prodromal and early disease stages and for interventional studies aimed at prevention or disease modification. The success of this research is dependent on having access to a well characterised, representative and sufficiently large population of individuals. Access to such a population remains challenging as clinical research has, historically, focussed on patients with dementia referred to secondary and tertiary services. The primary care system in the United Kingdom allows access to a true prodromal population prior to symptoms emerging and specialist referral. We report the development and recruitment rates of the CHARIOT register, a primary care-based recruitment register for research into the prevention of dementia. The CHARIOT register was designed specifically to support recruitment into observational natural history studies of pre-symptomatic or prodromal dementia stages, and primary or secondary prevention pharmaceutical trials or other prevention strategies for dementia and other cognitive problems associated with ageing.Participants were recruited through searches of general practice lists across the west and central London regions. Invitations were posted to individuals aged between 60 and 85 years, without a diagnosis of dementia. Upon consent, a minimum data set of demographic and contact details was extracted from the patient's electronic health record.To date, 123 surgeries participated in the register, recruiting a total of 24,509 participants-a response rate of 22.3%. The age, gender and ethnicity profiles of participants closely match that of the overall eligible population. Higher response rates tended to be associated with larger practices (r = 0.34), practices with a larger older population (r = 0.27), less socioeconomically disadvantaged practices (r = 0.68), and practices with a higher proportion of White patients (r = 0.82).Response rates are comparable to other registers reported in the literature, and indicate good interest and support for a research register and for participation in research for the prevention of age-related neurodegenerative diseases and dementia. We consider that the simplicity of the approach means that this system is easily scalable and replicable across the UK and internationally