901 research outputs found
Neuromuscular organization and aminergic modulation of contractions in the Drosophila ovary
Background: The processes by which eggs develop in the insect ovary are well characterized. Despite a large number of Drosophila mutants that cannot lay eggs, the way that the egg is moved along the reproductive tract from ovary to uterus is less well understood. We remedy this with an integrative study on the reproductive tract muscles (anatomy, innervation, contractions, aminergic modulation) in female flies. Results: Each ovary, consisting of 15-20 ovarioles, is surrounded by a contractile meshwork, the peritoneal sheath. Individual ovarioles are contained within a contractile epithelial sheath. Both sheaths contain striated muscle fibres. The oviduct and uterine walls contain a circular striated muscle layer. No longitudinal muscle fibres are seen. Neurons that innervate the peritoneal sheath and lateral oviduct have many varicosities and terminate in swellings just outside the muscles of the peritoneal sheath. They all express tyrosine decarboxylase (required for tyramine and octopamine synthesis) and Drosophila vesicular monoamine transporter (DVMAT). No fibres innervate the ovarioles. The common oviduct and uterus are innervated by two classes of neurons, one with similar morphology to those of the peritoneal sheath and another with repeated branches and axon endings similar to type I neuromuscular junctions. In isolated genital tracts from 3- and 7-day old flies, each ovariole contracts irregularly (12.5 +/- 6.4 contractions/minute; mean +/- 95% confidence interval). Peritoneal sheath contractions (5.7 +/- 1.6 contractions/minute) move over the ovary, from tip to base or vice versa, propagating down the oviduct. Rhythmical spermathecal rotations (1.5 +/- 0.29 contractions/minute) also occur. Each genital tract organ exhibits its own endogenous myogenic rhythm. The amplitude of contractions of the peritoneal sheath increase in octopamine (100 nM, 81% P < 0.02) but 1 mu M tyramine has no effect. Neither affects the frequency of peritoneal sheath contractions. Conclusion: The muscle fibres of the reproductive tract are circular and have complex bursting myogenic rhythms under octopaminergic neuromodulation. We propose a new model of tissue-specific actions of octopamine, in which strengthening of peritoneal sheath contractions, coupled with relaxation of the oviduct, eases ovulation. This model accounts for reduced ovulation in flies with mutations in the octopaminergic system
The ultraluminous X-ray source NGC 5643 ULX1: a large stellar mass black hole accreting at super-Eddington rates?
A sub-set of the brightest ultraluminous X-ray sources (ULXs), with X-ray luminosities well above 1040 erg sâ1, typically have energy spectra which can be well described as hard power laws, and short-term variability in excess of âŒ10âperâcent. This combination of properties suggests that these ULXs may be some of the best candidates to host intermediate-mass black holes (IMBHs), which would be accreting at sub-Eddington rates in the hard state seen in Galactic X-ray binaries. In this work, we present a temporal and spectral analysis of all of the available XMMâNewton data from one such ULX, the previously poorly studied 2XMM J143242.1â440939, located in NGC 5643. We report that its high-quality EPIC spectra can be better described by a broad, thermal component, such as an advection-dominated disc or an optically thick Comptonizing corona. In addition, we find a hint of a marginal change in the short-term variability which does not appear to be clearly related to the source unabsorbed luminosity. We discuss the implications of these results, excluding the possibility that the source may be host an IMBH in a low state, and favouring an interpretation in terms of super-Eddington accretion on to a black hole of stellar origin. The properties of NGC 5643 ULX1 allow us to associate this source to the population of the hard/ultraluminous ULX class
The three-dimensional random field Ising magnet: interfaces, scaling, and the nature of states
The nature of the zero temperature ordering transition in the 3D Gaussian
random field Ising magnet is studied numerically, aided by scaling analyses. In
the ferromagnetic phase the scaling of the roughness of the domain walls,
, is consistent with the theoretical prediction .
As the randomness is increased through the transition, the probability
distribution of the interfacial tension of domain walls scales as for a single
second order transition. At the critical point, the fractal dimensions of
domain walls and the fractal dimension of the outer surface of spin clusters
are investigated: there are at least two distinct physically important fractal
dimensions. These dimensions are argued to be related to combinations of the
energy scaling exponent, , which determines the violation of
hyperscaling, the correlation length exponent , and the magnetization
exponent . The value is derived from the
magnetization: this estimate is supported by the study of the spin cluster size
distribution at criticality. The variation of configurations in the interior of
a sample with boundary conditions is consistent with the hypothesis that there
is a single transition separating the disordered phase with one ground state
from the ordered phase with two ground states. The array of results are shown
to be consistent with a scaling picture and a geometric description of the
influence of boundary conditions on the spins. The details of the algorithm
used and its implementation are also described.Comment: 32 pp., 2 columns, 32 figure
Crossover from 2-dimensional to 1-dimensional collective pinning in NbSe3
We have fabricated NbSe structures with widths comparable to the
Fukuyama-Lee-Rice phase-coherence length. For samples already in the
2-dimensional pinning limit, we observe a crossover from 2-dimensional to
1-dimensional collective pinning when the crystal width is less than 1.6
m, corresponding to the phase-coherence length in this direction. Our
results show that surface pinning is negligible in our samples, and provide a
means to probe the dynamics of single domains giving access to a new regime in
charge-density wave physics.Comment: 4 pages, 2 figures, and 1 table. Accepted for publication in Physical
Review
Percolation in three-dimensional random field Ising magnets
The structure of the three-dimensional random field Ising magnet is studied
by ground state calculations. We investigate the percolation of the minority
spin orientation in the paramagnetic phase above the bulk phase transition,
located at [Delta/J]_c ~= 2.27, where Delta is the standard deviation of the
Gaussian random fields (J=1). With an external field H there is a disorder
strength dependent critical field +/- H_c(Delta) for the down (or up) spin
spanning. The percolation transition is in the standard percolation
universality class. H_c ~ (Delta - Delta_p)^{delta}, where Delta_p = 2.43 +/-
0.01 and delta = 1.31 +/- 0.03, implying a critical line for Delta_c < Delta <=
Delta_p. When, with zero external field, Delta is decreased from a large value
there is a transition from the simultaneous up and down spin spanning, with
probability Pi_{uparrow downarrow} = 1.00 to Pi_{uparrow downarrow} = 0. This
is located at Delta = 2.32 +/- 0.01, i.e., above Delta_c. The spanning cluster
has the fractal dimension of standard percolation D_f = 2.53 at H = H_c(Delta).
We provide evidence that this is asymptotically true even at H=0 for Delta_c <
Delta <= Delta_p beyond a crossover scale that diverges as Delta_c is
approached from above. Percolation implies extra finite size effects in the
ground states of the 3D RFIM.Comment: replaced with version to appear in Physical Review
Screening for Intimate Partner Violence, Elder Abuse, and Abuse of Vulnerable Adults: Evidence Report and Systematic Review for the US Preventive Services Task Force
Importance: Intimate partner violence (IPV), elder abuse, and abuse of vulnerable adults are common and result in adverse health outcomes. Objective: To review the evidence on screening and interventions for IPV, elder abuse, and abuse of vulnerable adults to inform the US Preventive Services Task Force. Data Sources: MEDLINE, Cochrane Library, EMBASE, and trial registries through October 4, 2017; references; experts; literature surveillance through August 1, 2018. Study Selection: English-language randomized clinical trials (RCTs), studies evaluating test accuracy, and cohort studies with a concurrent control group assessing harms. Data Extraction and Synthesis: Dual review of titles and abstracts, full-text articles, and study quality; qualitative synthesis of findings. Data were not pooled, primarily because of heterogeneity of populations, interventions, and outcomes. Main Outcomes and Measures: Abuse or neglect, morbidity caused by abuse, test accuracy, and harms. Results: Thirty studies were included (N = 14959). Three RCTs (n = 3759) compared IPV screening with no screening; none found significant improvements in outcomes (eg, IPV or quality of life) over 3 to 18 months and 2 (n = 935) reported no harms of screening. Nine studies assessed tools to detect any past-year or current IPV in women; for past-year IPV (5 studies [n = 6331]), sensitivity of 5 tools ranged from 65% to 87% and specificity ranged from 80% to 95%. The accuracy of 5 tools (4 studies [n = 1795]) for detecting current abuse varied widely; sensitivity ranged from 46% to 94% and specificity ranged from 38% to 95%. Eleven RCTs (n = 6740) evaluated interventions for women with screen-detected IPV. Two enrolling pregnant women (n = 575) found significantly less IPV among women in the intervention group: 1 home visiting intervention (standardized mean difference [SMD], -0.34 [95% CI, -0.59 to -0.08]) and 1 behavioral counseling intervention for multiple risks (IPV, smoking, depression, tobacco exposure) (SMD, -0.40 [95% CI, -0.68 to -0.12]). No studies evaluated screening or interventions for elder abuse or abuse of vulnerable adults. One study assessing a screening tool for elder abuse had poor accuracy (sensitivity, 46% and specificity, 73% for detecting physical or verbal abuse). Conclusions and Relevance: Although available screening tools may reasonably identify women experiencing IPV, trials of IPV screening in adult women did not show a reduction in IPV or improvement in quality of life over 3 to 18 months. Limited evidence suggested that home visiting and behavioral counseling interventions that address multiple risk factors may lead to reduced IPV among pregnant or postpartum women. No studies assessed screening or treatment for elder abuse and abuse of vulnerable adults
Screening for Eating Disorders in Adolescents and Adults: Evidence Report and Systematic Review for the US Preventive Services Task Force
Importance: Eating disorders are associated with adverse health and social outcomes. Objective: To review the evidence on screening for eating disorders in adolescents and adults to inform the US Preventive Services Task Force. Data Sources: MEDLINE, Cochrane Library, PsycINFO, and trial registries through December 19, 2020; surveillance through January 1, 2022. Study Selection: English-language studies of screening test accuracy, randomized clinical trials (RCTs) of screening or interventions for eating disorders in populations with screen-detected or previously untreated eating disorders (trials limited to populations who are underweight were ineligible). Data Extraction and Synthesis: Dual review of abstracts, full-text articles, and study quality. Meta-analysis of test accuracy studies and intervention trials. Main Outcomes and Measures: Test accuracy, eating disorder symptom severity, quality of life, depression, and harms. Results: Fifty-seven studies were included (N = 10 773); 3 (n = 1073) limited to adolescents (mean or median age, 14-15 years). No study directly evaluated the benefits and harms of screening. Seventeen studies (n = 6804) evaluated screening test accuracy. The SCOFF questionnaire (cut point â„2) had a pooled sensitivity of 84% (95% CI, 74% to 90%) and pooled specificity of 80% (95% CI, 65% to 89%) in adults (10 studies, n = 3684). Forty RCTs (n = 3969) evaluated interventions for eating disorders; none enrolled a screen-detected population. Lisdexamfetamine for binge eating disorder (4 RCTs; n = 900) was associated with larger reductions in eating disorder symptom severity on the Yale-Brown Obsessive Compulsive Scale modified for binge eating (YBOCS-BE) than placebo (pooled mean difference, -5.75 [95% CI, -8.32 to -3.17]). Two RCTs (n = 465) of topiramate for binge eating disorder found larger reductions in YBOCS-BE scores associated with topiramate than placebo, from -6.40 (95% CI, -8.16 to -4.64) to -2.55 (95% CI, -4.22 to -0.88). Nine pharmacotherapy trials (n = 2006) reported on harms. Compared with placebo, lisdexamfetamine was associated with higher rates of dry mouth, headache, and insomnia, and topiramate was associated with higher rates of paresthesia, taste perversion, confusion, and concentration difficulty. Twenty-four trials (n = 1644) assessed psychological interventions. Guided self-help for binge eating disorder improved eating disorder symptom severity more than control (pooled standardized mean difference, -0.96 [95% CI, -1.26 to -0.67]) (5 studies, n = 391). Evidence on other interventions was limited. Conclusions and Relevance: No studies directly assessed the benefits and harms of screening. The SCOFF questionnaire had adequate accuracy for detecting eating disorders among adults. No treatment trials enrolled screen-detected populations; guided self-help, lisdexamfetamine, and topiramate were effective for reducing eating disorder symptom severity among referred populations with binge eating disorder, but pharmacotherapies were also associated with harms
Constraining the mass of dark photons and axion-like particles through black-hole superradiance
Ultralight bosons and axion-like particles appear naturally in different
scenarios and could solve some long-standing puzzles. Their detection is
challenging, and all direct methods hinge on unknown couplings to the Standard
Model of particle physics. However, the universal coupling to gravity provides
model-independent signatures for these fields. We explore here the superradiant
instability of spinning black holes triggered in the presence of such fields.
The instability taps angular momentum from and limits the maximum spin of
astrophysical black holes. We compute, for the first time, the spectrum of the
most unstable modes of a massive vector (Proca) field for generic black-hole
spin and Proca mass. The observed stability of the inner disk of stellar-mass
black holes can be used to derive \emph{direct} constraints on the mass of dark
photons in the mass range . By including also higher azimuthal modes, similar
constraints apply to axion-like particles in the mass range
.
Likewise, mass and spin distributions of supermassive BHs --~as measured
through continuum fitting, K iron line, or with the future space-based
gravitational-wave detector LISA~-- imply indirect bounds in the mass range
approximately , for both axion-like particles and dark photons. Overall,
superradiance allows to explore a region of approximately orders of
magnitude in the mass of ultralight bosons
Transverse phase-locking in fully frustrated Josephson junction arrays: a new type of fractional giant steps
We study, analytically and numerically, phase locking of driven vortex
lattices in fully-frustrated Josephson junction arrays at zero temperature. We
consider the case when an ac current is applied {\it perpendicular} to a dc
current. We observe phase locking, steps in the current-voltage
characteristics, with a dependence on external ac-drive amplitude and frequency
qualitatively different from the Shapiro steps, observed when the ac and dc
currents are applied in parallel. Further, the critical current increases with
increasing transverse ac-drive amplitude, while it decreases for longitudinal
ac-drive. The critical current and the phase-locked current step width,
increase quadratically with (small) amplitudes of the ac-drive. For larger
amplitudes of the transverse ac-signal, we find windows where the critical
current is hysteretic, and windows where phase locking is suppressed due to
dynamical instabilities. We characterize the dynamical states around the
phase-locking interference condition in the curve with voltage noise,
Lyapunov exponents and Poincar\'e sections. We find that zero temperature
phase-locking behavior in large fully frustrated arrays is well described by an
effective four plaquette model.Comment: 12 pages, 11 figure
Black Hole Spin via Continuum Fitting and the Role of Spin in Powering Transient Jets
The spins of ten stellar black holes have been measured using the
continuum-fitting method. These black holes are located in two distinct classes
of X-ray binary systems, one that is persistently X-ray bright and another that
is transient. Both the persistent and transient black holes remain for long
periods in a state where their spectra are dominated by a thermal accretion
disk component. The spin of a black hole of known mass and distance can be
measured by fitting this thermal continuum spectrum to the thin-disk model of
Novikov and Thorne; the key fit parameter is the radius of the inner edge of
the black hole's accretion disk. Strong observational and theoretical evidence
links the inner-disk radius to the radius of the innermost stable circular
orbit, which is trivially related to the dimensionless spin parameter a_* of
the black hole (|a_*| < 1). The ten spins that have so far been measured by
this continuum-fitting method range widely from a_* \approx 0 to a_* > 0.95.
The robustness of the method is demonstrated by the dozens or hundreds of
independent and consistent measurements of spin that have been obtained for
several black holes, and through careful consideration of many sources of
systematic error. Among the results discussed is a dichotomy between the
transient and persistent black holes; the latter have higher spins and larger
masses. Also discussed is recently discovered evidence in the transient sources
for a correlation between the power of ballistic jets and black hole spin.Comment: 30 pages. Accepted for publication in Space Science Reviews. Also to
appear in hard cover in the Space Sciences Series of ISSI "The Physics of
Accretion onto Black Holes" (Springer Publisher). Changes to Sections 5.2,
6.1 and 7.4. Section 7.4 responds to Russell et al. 2013 (MNRAS, 431, 405)
who find no evidence for a correlation between the power of ballistic jets
and black hole spi
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