1,209 research outputs found
Traité scientifique et industriel des plantes textiles
Conté: 2. La ramie : culture et décorticage. 3. La ramie : dégommage et travail industrie
Current - voltage characteristics of break junctions of high- superconductors
The current-voltage (-) characteristics of break junctions of
polycrystalline LaSrCuO,
YLuBaCuO,
BiPbSrCaCuO and composite
YBaCuO + Ag are investigated. The experimental -
curves exhibit the specific peculiarities of
superconductor/normal-metal/superconductor junctions. The relation between an
- characteristic of network of weak links and - dependencies of
typical weak links is suggested to describe the experimental data. The -
curves of typical weak links are calculated by the K\"{u}mmel - Gunsenheimer -
Nicolsky model considering the multiple Andreev reflections.Comment: 9 pages, 5 figures, 2 Table
Current-voltage characteristics of quasi-one-dimensional superconductors: An S-curve in the constant voltage regime
Applying a constant voltage to superconducting nanowires we find that its
IV-characteristic exhibits an unusual S-behavior. This behavior is the direct
consequence of the dynamics of the superconducting condensate and of the
existence of two different critical currents: j_{c2} at which the pure
superconducting state becomes unstable and j_{c1}<j_{c2} at which the phase
slip state is realized in the system.Comment: 4 pages, 5 figures, replaced with minor change
Experimental and Clinical Use of Therapeutic Hypothermia for Ischemic Stroke: Opportunities and Limitations
Stroke remains a disease with a serious impact on quality of life but few effective treatments exist. There is an urgent need to develop and/or improve neuroprotective strategies to combat this. Many drugs proven to be neuroprotective in experimental models fail to improve patient outcome in a clinical setting. An emerging treatment, therapeutic hypothermia (TH), is a promising neuroprotective therapy in stroke management. Several studies with TH in experimental models and small clinical trials have shown beneficial effects. Despite this, implementation into the clinical setting is still lacking due to methodological considerations as well as hypothermia-related complications. This paper discusses the possible opportunities and limitations of the use of TH in animal models and the translation into the clinic
Mild hypothermia causes differential, time-dependent changes in cytokine expression and gliosis following endothelin-1-induced transient focal cerebral ischemia
Background: Stroke is an important cause of morbidity and mortality and few therapies exist thus far. Mild hypothermia (33 degrees C) is a promising neuroprotective strategy to improve outcome after ischemic stroke. However, its complete mechanism of action has not yet been fully elaborated. This study is the first to investigate whether this neuroprotection occurs through modulation of the neuroinflammatory response after stroke in a time-dependent manner. Methods: The Endothelin-1 (Et-1) model was used to elicit a transient focal cerebral ischemia in male Wistar rats. In this model, the core and penumbra of the insult are represented by the striatum and the cortex respectively. We assessed the effects of 2 hours of hypothermia, started 20 minutes after Et-1 injection on neurological outcome and infarct volume. Furthermore, pro-and anti-inflammatory cytokine expression was determined using ELISA. Microgliosis and astrogliosis were investigated using CD-68 and GFAP staining respectively. All parameters were determined 8, 24, 72 hours and 1 week after the administration of Et-1. Results: Et-1 infusion caused neurological deficit and a reproducible infarct size which increased up to 3 days after the insult. Both parameters were significantly reduced by hypothermia. The strongest reduction in infarct volume with hypothermia, at 3 days, corresponded with increased microglial activation. Reducing the brain temperature affected the stroke induced increase in interleukin-1 beta and tumor necrosis factor a in the striatum, 8 hours after its induction, but not at later time points. Transforming growth factor beta increased as a function of time after the Et-1-induced insult and was not influenced by cooling. Hypothermia reduced astrogliosis at 1 and 3 days after stroke onset. Conclusions: The beneficial effects of hypothermia after stroke on infarct volume and functional outcome coincide with a time-dependent modulation of the cytokine expression and gliosis
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