Analytical Tachyonic Lump Solutions in Open Superstring Field Theory

We construct a classical solution in the GSO(-) sector in the framework of a Wess-Zumino-Witten-like open superstring field theory on a non-BPS D-brane. We use an su(2) supercurrent, which is obtained by compactifying a direction to a circle with the critical radius, in order to get analytical tachyonic lump solutions to the equation of motion. By investigating the action expanded around a solution we find that it represents a deformation from a non-BPS D-brane to a D-brane-anti-D-brane system at the critical value of a parameter which is contained in classical solutions. Although such a process was discussed in terms of boundary conformal field theory before, our study is based on open superstring field theory including interaction terms.Comment: 17 pages, references adde

AdS and pp-wave D-particle superalgebras

We derive anticommutators of supercharges with a brane charge for a D-particle in AdS(2) x S(2) and pp-wave backgrounds. A coset GL(2|2)/(GL(1))^4 and its Penrose limit are used with the supermatrix-valued coordinates for the AdS and the pp-wave spaces respectively. The brane charges have position dependence, and can be absorbed into bosonic generators by shift of momenta which results in closure of the superalgebras.Comment: 15 page

Superstring field theory equivalence: Ramond sector

We prove that the finite gauge transformation of the Ramond sector of the modified cubic superstring field theory is ill-defined due to collisions of picture changing operators. Despite this problem we study to what extent could a bijective classical correspondence between this theory and the (presumably consistent) non-polynomial theory exist. We find that the classical equivalence between these two theories can almost be extended to the Ramond sector: We construct mappings between the string fields (NS and Ramond, including Chan-Paton factors and the various GSO sectors) of the two theories that send solutions to solutions in a way that respects the linearized gauge symmetries in both sides and keeps the action of the solutions invariant. The perturbative spectrum around equivalent solutions is also isomorphic. The problem with the cubic theory implies that the correspondence of the linearized gauge symmetries cannot be extended to a correspondence of the finite gauge symmetries. Hence, our equivalence is only formal, since it relates a consistent theory to an inconsistent one. Nonetheless, we believe that the fact that the equivalence formally works suggests that a consistent modification of the cubic theory exists. We construct a theory that can be considered as a first step towards a consistent RNS cubic theory.Comment: v1: 24 pages. v2: 27 pages, significant modifications of the presentation, new section, typos corrected, references adde

Worldvolume Superalgebra Of BLG Theory With Nambu-Poisson Structure

Recently it was proposed that the Bagger-Lambert-Gustavsson theory with Nambu-Poisson structure describes an M5-brane in a three-form flux background. In this paper we investigate the superalgebra associated with this theory. We derive the central charges corresponding to M5-brane solitons in 3-form backgrounds. We also show that double dimensional reduction of the superalgebra gives rise to the Poisson bracket terms of a non-commutative D4-brane superalgebra. We provide interpretations of the D4-brane charges in terms of spacetime intersections.Comment: 23 pages; references added, section 4 clarification

SIRT7 Links H3K18 Deacetylation to Maintenance of Oncogenic Transformation

Sirtuin proteins regulate diverse cellular pathways that influence genomic stability, metabolism, and ageing. SIRT7 is a mammalian sirtuin whose biochemical activity, molecular targets, and physiologic functions have been unclear. Here we show that SIRT7 is an NAD$^+$-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase that stabilizes the transformed state of cancer cells. Genome-wide binding studies reveal that SIRT7 binds to promoters of a specific set of gene targets, where it deacetylates H3K18Ac and promotes transcriptional repression. The spectrum of SIRT7 target genes is defined in part by its interaction with the cancer-associated ETS transcription factor ELK4, and comprises numerous genes with links to tumour suppression. Notably, selective hypoacetylation of H3K18Ac has been linked to oncogenic transformation, and in patients is associated with aggressive tumour phenotypes and poor prognosis. We find that deacetylation of H3K18Ac by SIRT7 is necessary for maintaining essential features of human cancer cells, including anchorage-independent growth and escape from contact inhibition. Moreover, SIRT7 is necessary for a global hypoacetylation of H3K18Ac associated with cellular transformation by the viral oncoprotein E1A. Finally, SIRT7 depletion markedly reduces the tumourigenicity of human cancer cell xenografts in mice. Together, our work establishes SIRT7 as a highly selective H3K18Ac deacetylase and demonstrates a pivotal role for SIRT7 in chromatin regulation, cellular transformation programs, and tumour formation in vivo

Superstring Vacua of 4-dimensional PP-Waves with Enhanced Supersymmetry

We study the superstring vacua constructed from the conformal field theories of the type H_4 x M, where H_4 denotes the super Nappi-Witten model (super WZW model on the 4-dimensional Heisenberg group H_4) and M denotes an arbitrary N=2 rational superconformal field theory with c=9. We define (type II) superstring vacua with 8 supercharges, which are twice as many as those on the backgrounds of H_4 x CY_3. We explicitly construct as physical vertices the space-time SUSY algebra that is a natural extension of H_4 Lie algebra. The spectrum of physical states is classified into two sectors: (1) strings freely propagating along the transverse plane of pp-wave geometry and possessing the integral U(1)_R-charges in M sector, and (2) strings that do not freely propagate along the transverse plane and possess the fractional U(1)_R-charges in M. The former behaves like the string excitations in the usual Calabi-Yau compactification, but the latter defines new sectors without changing the physics in ``bulk'' space. We also analyze the thermal partition functions of these systems, emphasizing the similarity to the DLCQ string theory. As a byproduct we prove the supersymmetric cancellation of conformal blocks in an arbitrary unitary N=2 SCFT of c=12 with the suitable GSO projection.Comment: 37 pages, no figures, v2: typo corrected, references added, v3: minor change

Supersymmetric Intersections of M-branes and pp-waves

We study supersymmetric intersections of M2 and M5 branes with different pp-waves of M-theory. We consider first M-brane probes in the background of pp-waves and determine under which conditions the embedding is supersymmetric. We particularize our formalism to the case of pp-waves with 32, 24 and 20 supersymmetries. We also construct supergravity solutions for the brane-wave system. Generically these solutions are delocalised along some directions transverse to the brane and preserve the same number of supersymmetries as in the brane probe approach.Comment: 41 pages, LaTeX; v2 references adde

Lysosome-mediated processing of chromatin in senescence

Cellular senescence is a stable proliferation arrest, a potent tumor suppressor mechanism, and a likely contributor to tissue aging. Cellular senescence involves extensive cellular remodeling, including of chromatin structure. Autophagy and lysosomes are important for recycling of cellular constituents and cell remodeling. Here we show that an autophagy/lysosomal pathway processes chromatin in senescent cells. In senescent cells, lamin A/C–negative, but strongly γ-H2AX–positive and H3K27me3-positive, cytoplasmic chromatin fragments (CCFs) budded off nuclei, and this was associated with lamin B1 down-regulation and the loss of nuclear envelope integrity. In the cytoplasm, CCFs were targeted by the autophagy machinery. Senescent cells exhibited markers of lysosomal-mediated proteolytic processing of histones and were progressively depleted of total histone content in a lysosome-dependent manner. In vivo, depletion of histones correlated with nevus maturation, an established histopathologic parameter associated with proliferation arrest and clinical benignancy. We conclude that senescent cells process their chromatin via an autophagy/lysosomal pathway and that this might contribute to stability of senescence and tumor suppression

Open superstring field theory I: gauge fixing, ghost structure, and propagator

The WZW form of open superstring field theory has linearized gauge invariances associated with the BRST operator Q and the zero mode η [subscript 0] of the picture minus-one fermionic superconformal ghost. We discuss gauge fixing of the free theory in a simple class of gauges using the Faddeev-Popov method. We find that the world-sheet ghost number of ghost and antighost string fields ranges over all integers, except one, and at any fixed ghost number, only a finite number of picture numbers appear. We calculate the propagators in a variety of gauges and determine the field-antifield content and the free master action in the Batalin-Vilkovisky formalism. Unlike the case of bosonic string field theory, the resulting master action is not simply related to the original gauge-invariant action by relaxing the constraint on the ghost and picture numbers.United States. Dept. of Energy (Cooperative rRsearch Agreement DE-FG02-05ER41360.

Comments on superstring field theory and its vacuum solution

We prove that the NS cubic superstring field theories are classically equivalent, regardless of the choice of Y_{-2} in their definition, and illustrate it by an explicit evaluation of the action of Erler's solution. We then turn to examine this solution. First, we explain that its cohomology is trivial also in the Ramond sector. Then, we show that the boundary state corresponding to it is identically zero. We conclude that this solution is indeed a closed string vacuum solution despite the absence of a tachyon field on the BPS D-brane.Comment: 15 pages, 1 figure; v2. typos correcte