Single-layer active-passive Al₂O₃ photonic integration platform

Amorphous Al2O3 is an attractive platform for integrated photonics, providing active and passive functionalities. We have developed an integration procedure to create active and passive regions at the same level on one wafer. This fabrication process reduces the number of fabrication steps compared to vertical integration of two materials. The main advantage is that all structures are defined within a single photolithography and etching step and are therefore automatically aligned. As a proof of principle, we demonstrated the luminescence of an active ring resonator with passive bus waveguide

Materials and modes of translation: Re-imagining inclusive “zero”-waste futures

In this paper, we present and reflect upon a creative and participatory approach for engaging citizens in imagining desirable “zero”-waste futures that include different values and perspectives. The approach emerged through a 4-month collaboration involving academic researchers and creative professionals and was prototyped in a formerly industrial neighborhood of Utrecht (het Werkspoorkwartier), currently being developed as a creative circular manufacturing area. With our approach, we inquire into and provide an alternative to predominant technology-centered policy visions, which portray the issues of waste as objective challenges that can be addressed through data-driven technological solutions. Such visions neglect many other perspectives and values, particularly those of citizens that face the issue of waste in everyday life, thus providing only a narrow vision of how the future might look like. To gather and articulate different perspectives on alternative “zero”-waste futures, we focus on citizen-science-inspired and speculative design methods to engage people and stimulate imagining futures that bring to light diverse values and perspectives. In the development of the methods, we work in close collaboration with creative practitioners, both in terms of anchoring the research in a real-world context and in terms of combining our different types of expertise. Reflecting on the project, we discuss the potential of our transdisciplinary approach and the co-produced methods to intervene in how we see and imagine alternative futures. We do so by taking “translation” as an analytical lens to understand how different meanings and visions are created through experiential, material, and affective modes of expression. Specifically, we will analyze the translations that occur in the processes of moving from abstract data to matters of concern, and from desirable futures to actionable presents. Looking at these multiple processes through the lens of translation will serve to investigate how different future imaginaries are generated through different materials and modalities of translation, offering different forms of engagement in shaping inclusive urban futures. Translation here will be conceptualized less as a perfect transference of information and more as an open-ended process of paying attention to different values, and identifying those matters for which to care for in our urban futures

Mode-splitting in a microring resonator for self-referenced biosensing

Self-referenced biosensing based on mode-splitting on a microring resonator is experimentally demonstrated. A Bragg grating integrated on the surface of the ring provides coupling between the clockwise and counterclockwise travelling modes of the pristine ring resonator lifting their degeneracy. The amount of mode-splitting is directly related to the reflectivity of the grating and it is only affected by structurally modifying the grating. Environmental perturbations to the surroundings of the gratings, such as temperature and bulk refractive index variations, have a minor effect on the amount of mode-splitting. This principle allows the realization of a self-referenced sensing scheme based on the detection of variations of the mode-splitting induced by structural changes to the grating. In this work, a polymethyl methacrylate (PMMA) Bragg grating is integrated onto a ring resonator in Al2O3. It is shown both theoretically and experimentally that the amount of splitting of a resonance varies minimally under temperature or bulk refractive index perturbations. However, the structural change of attaching a layer of biomolecules inside the grating does affect its reflectivity and the amount of mode splitting present. This result represents the first proof-of-concept demonstration of an integrated mode-splitting biosensor insensitive to temperature and refractive index variations of the liquid matrix where the molecules to be detected are embedded. The reported results pave the road towards the realization of truly self-referenced biosensors

High index contrast photonic platforms for on-chip Raman spectroscopy

Nanophotonic waveguide enhanced Raman spectroscopy (NWERS) is a sensing technique that uses a highly confined waveguide mode to excite and collect the Raman scattered signal from molecules in close vicinity of the waveguide. The most important parameters defining the figure of merit of an NWERS sensor include its ability to collect the Raman signal from an analyte, i.e. "the Raman conversion efficiency" and the amount of "Raman background" generated from the guiding material. Here, we compare different photonic integrated circuit (PIC) platforms capable of on-chip Raman sensing in terms of the aforementioned parameters. Among the four photonic platforms under study, tantalum oxide and silicon nitride waveguides exhibit high signal collection efficiency and low Raman background. In contrast, the performance of titania and alumina waveguides suffers from a strong Raman background and a weak signal collection efficiency, respectively

Cardiomyocyte hypocontractility and reduced myofibril density in end-stage pediatric cardiomyopathy

Dilated cardiomyopathy amongst children (pediatric cardiomyopathy, pediatric CM) is associated with a high morbidity and mortality. Because little is known about the pathophysiology of pediatric CM, treatment is largely based on adult heart failure therapy. The reason for high morbidity and mortality is largely unknown as well as data on cellular pathomechanisms is limited. Here, we assessed cardiomyocyte contractility and protein expression to define cellular pathomechanisms in pediatric CM. Explanted heart tissue of 11 pediatric CM patients and 18 controls was studied. Contractility was measured in single membrane-permeabilized cardiomyocytes and protein expression was assessed with gel electrophoresis and western blot analysis. We observed increased Ca2+-sensitivity of myofilaments which was due to hypophosphorylation of cardiac troponin I, a feature commonly observed in adult DCM. We also found a significantly reduced maximal force generating capacity of pediatric CM cardiomyocytes, as well as a reduced passive force development over a range of sarcomere lengths. Myofibril density was reduced in pediatric CM compared to controls. Correction of maximal force and passive force for myofibril density normalized forces in pediatric CM cardiomyocytes to control values. This implies that the hypocontractility was caused by the reduction in myofibril density. Unlike in adult DCM we did not find an increase in compliant titin isoform expression in end-stage pediatric CM. The limited ability of pediatric CM patients to maintain myofibril density might have contributed to their early disease onset and severity

Al2O3 microring resonators for the detectin of a cancer biomarker in undiluted urine

: Concentrations down to 3 nM of the rhS100A4 protein, associated with human tumor development, have been detected in undiluted urine using an integrated sensor based on microring resonators in the emerging Al2O3 photonic platform. The fabricated microrings were designed for operation in the C-band (λ = 1565 nm) and exhibited a high-quality factor in air of 3.2 × 105. The bulk refractive index sensitivity of the devices was ~100 nm/RIU (for TM polarization) with a limit of detection of ~10−6 RIU. A surface functionalization protocol was developed to allow for the selective binding of the monoclonal antibodies designed to capture the target biomarker to the surface of the Al2O3 microrings. The detection of rhS100A4 proteins at clinically relevant concentrations in urine is a big milestone towards the use of biosensors for the screening and early diagnosis of different cancers. Biosensors based on this microring technology can lead to portable, multiplexed and easy-to-use point of care device

Al2O3 microresonators for passive and active sensing applications

The Al2O3 waveguide technology was explored for sensing applications. Passive microring resonators with a quality factor in air of 3.2×105 were developed with a bulk refractive index sensitivity of ~100 nm/RIU and limit of detection of ~10-6 RIU. These were functionalized to detect the biomarker rhS100A4 from urine down to concentrations of 3 nM. Furthermore, Al2O3:Yb3+ microdisk lasers were realized that exhibited single mode lasing operation in water. Their lasing wavelength was tuned by varying the bulk refractive index and a bulk refractive index sensitivity of ~20 nm/RIU with a LOD of ~3×10-6 was achieved

Observation of open scattering channels

The existence of fully transmissive eigenchannels ("open channels") in a random scattering medium is a counterintuitive and unresolved prediction of random matrix theory. The smoking gun of such open channels, namely a bimodal distribution of the transmission efficiencies of the scattering channels, has so far eluded experimental observation. We observe an experimental distribution of transmission efficiencies that obeys the predicted bimodal Dorokhov-Mello-Pereyra-Kumar distribution. Thereby we show the existence of open channels in a linear optical scattering system. The characterization of the scattering system is carried out by a quantum-optical readout method. We find that missing a single channel in the measurement already prevents detection of the open channels, illustrating why their observation has proven so elusive until now. Our work confirms a long-standing prediction of random matrix theory underlying wave transport through disordered systems.Comment: 9 pages including methods and supplementary materials. 3 figure