Sexual Orientation and Gender Expression as Predictors of SOGIE-Based Harassment

The current study examined which individuals are most at risk for becoming targets of SOGIE-based harassment (specifically, White, male sexual minorities or White, male gender nonconforming individuals). The study also explored potential motivations behind SOGIE-based harassment (specifically, violations of normality and violations of morality) and whether these motivations are predicted by individual differences (specifically, sexual prejudice, beliefs in heteronormativity, tolerance of ambiguity, and adherence to gender norms). College students (n = 206; 67.5% female) were randomly assigned to one of four conditions, each with a different male target (straight/gender conforming, straight/gender nonconforming, gay/gender conforming, gay/gender nonconforming). Students saw a picture of target and read a short vignette describing the target. They then answered questions about their feelings towards the target, as well as questions about themselves. Contrary to hypotheses, participants rated gay targets more positively than straight targets, and gender nonconforming targets more positively than gender conforming targets. It was also found that for gay, gender nonconforming targets, female participants gave more positive ratings than male participants and that heteronormativity negatively predicted positive ratings

Gender-Based Harassment in Early Adolescence: Group and Individual Predictors of Perpetration

The current study examined gender-based harassment in early adolescence and the characteristics of individuals who perpetrate such harassment (specifically, experiences with witnessing gender-based harassment and gender identity). Students in seventh and eighth grade (n = 483; 247 girls, 236 boys) completed surveys containing measures of gender identity (perceived same and other-gender typicality, felt pressure to conform to gender norms, and gender contentedness), and questions about witnessing and perpetrating teasing, bullying, and rejection because of a peer’s gender typicality or atypicality. Results revealed that the more GBH an individual had previously witnessed in their classroom, the more likely they were to report perpetrating GBH themselves. Additionally, boys high in other-gender typicality reported perpetrating more GBH than boys low in other-gender typicality. For girls, same-gender typicality interacted with felt pressure to conform to gender norms to predict GBH perpetration. For girls low in felt pressure, same-gender typicality negatively predicted GBH perpetration. For girls high in felt pressure, same-gender typicality positively predicted GBH perpetration

K-Knuth Equivalence for Increasing Tableaux

A K-theoretic analogue of RSK insertion and Knuth equivalence relations was first introduced in 2006 by Buch, Kresch, Shimozono, Tamvakis, and Yong. The resulting K-Knuth equivalence relations on words and increasing tableaux on [n] has prompted investigation into the equivalence classes of tableaux arising from these relations. Of particular interest are the tableaux that are unique in their class, which we refer to as unique rectification targets (URTs). In this paper we give several new families of URTs and a bound on the length of intermediate words connecting two K-Knuth equivalent words. In addition, we describe an algorithm to determine if two words are K-Knuth equivalent and to compute all K-Knuth equivalence classes of tableaux on [n].Comment: 35 page

Development of a pointing, acquisition, and tracking system for a CubeSat optical communication module

Miniaturized satellites such as CubeSats continue to improve their capabilities to enable missions that can produce significant amounts of data. For most CubeSat missions, data must be downlinked during short low-earth orbit ground station passes, a task currently performed using traditional radio systems. Free-space optical communications take advantage of the high gain of a narrow optical beam to achieve better link efficiency, allowing more valuable data to be downlinked over the mission lifetime. We present the Nanosatellite Optical Downlink Experiment (NODE) design, capable of providing a typical 3U (30 x 10 x 10 cm) CubeSat with a comparatively high data-rate downlink. The NODE optical communication module is designed to fit within a 5 x 10 x 10 cm volume, weigh less than 1 kg, and consume no more than 10Wof power during active communication periods. Our design incorporates a fine-steering mechanism and beacon-tracking system to achieve a 10 Mbps link rate. We describe the system-level requirements and designs for key components, including a transmitter, a beacon tracking camera, and a fast-steering mirror. We present simulation results of the uplink beacon tracking and fine steering of the downlink beam, including the effects of atmospheric fading and on-orbit environmental disturbances to demonstrate the feasibility of this approach. © (2015) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only

Spontaneous Pneumothorax in an Allogeneic Cell Transplant Recipient with Invasive Pulmonary Aspergillosis and Antecedent RSV Pneumonitis.

We report a case of invasive pulmonary aspergillosis (IPA) following respiratory syncytial virus infection in an allogeneic hematopoietic stem cell transplant (HSCT) recipient with chronic graft-versus-host disease. Delayed diagnosis of IPA resulted in the development of a pneumothorax, a rare consequence of fungal pneumonia. Respiratory virus infections are often harbingers of other infective organisms in HSCT recipients. More aggressive diagnostic investigations such as computed tomography scans of the thorax and bronchoscopy with bronchoalveolar lavage should be considered early in any HSCT patient presenting with respiratory virus pneumonia, particularly if atypical features are present or recovery is delayed

The concentration of ethanol affects its penetration rate in bovine cardiac and hepatic tissues

  Introduction. Ethanol is a commonly used fixative. Fixation of the inner layers of the tissue depends on the ability of the fixative to diffuse into the tissue. It is unknown whether the concentration of ethanol affects its penetration into tissues. This study aimed to compare the penetration rates of 50% and 100% ethanol into bovine heart and liver tissues. Materials and methods. The penetration distance and tissue shrinkage or expansion were measured by analysing the digital images of the heart and liver tissues before and after immersion in ethanol at 20°C for 2, 6, 24 or 30 hours. The penetration coefficients were calculated as the slope of the regression line using the linear regres­sion function between the penetration distance and square root of fixation time. Differences in tissue shrinkage or expansion and penetration distance at various time points between the two concentrations of ethanol were analysed using a mixed design ANOVA followed by Bonferroni’s post-hoc test. Results. The penetration distance of 100% ethanol was significantly greater in both heart and liver tissues com­pared with that of 50% ethanol (n = 4, p < 0.05 for both). 100% ethanol shrank immersed liver tissue signifi­cantly more than 50% ethanol (p = 0.002), but the shrinkage of the heart tissue caused by two concentrations of ethanol did not significantly differ (p = 0.054). The greater penetration distance of 100% over 50% ethanol remained unchanged after normalising the penetration distance to the individual tissue’s shrinkage (n = 4, p < 0.001). The mean penetration coefficient of 100% ethanol was significantly greater than 50% ethanol in the heart tissue (0.906 vs. 0.442, p = 0.003) and in the liver tissue (0.988 vs. 0.622, p = 0.028). Conclusions. It was proven that in two types of tissue that substantially differ in histological structures, 100% ethanol penetrated tissue significantly faster than 50% ethanol

Verbal Fluency in a National Sample: Telephone Administration Methods

Objectives: Describe novel methods for ascertaining verbal fluency in a large national sample of adults, examine demographic factors influencing performance, and compare scores to studies using in-person assessment. Methods/Design: Participants were from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, a national, population-based, longitudinal study of stroke in adults aged 45 years an older. Letter and semantic fluency were gathered, using Letter “F” and Animal Naming, via a telephone-based assessment with computer-assisted scoring of digital recordings. Results: Initial letter and semantic fluency scores were obtained on 18,505 and 18,072 participants, respectively. For both fluency tests, scores were normally distributed. Younger age and more years of education were associated with better performances (p<0.0001). The mean and standard deviation for matched subgroups, based on age, gender, and education, were quite comparable to scores reported out of samples using an in-person administration format. Telephone-based assessment also allowed for a level of quality control not available via in-person measurement. Conclusions: Telephone-based assessment of verbal fluency and computer-assisted scoring programs designed for this study facilitated large scale data acquisition, storage, and scoring of protocols. The resulting scores have similar characteristics to those obtained by traditional methods. These findings extend validation of cognitive assessment methods, using survey research staff and computer-assisted technology for test administration

Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers

<p>Abstract</p> <p>Background</p> <p>FBI-1 (factor that binds to the inducer of short transcripts of human immunodeficiency virus-1) is a member of the POK (POZ and Kruppel) family of transcription factors and play important roles in cellular differentiation and oncogenesis. Recent evidence suggests that FBI-1 is expressed at high levels in a subset of human lymphomas and some epithelial solid tumors. However, the function of FBI-1 in human ovarian cancers remains elusive.</p> <p>Results</p> <p>In this study, we investigated the role of FBI-1 in human ovarian cancers, in particularly, its function in cancer cell invasion via modulating membrane type 1-matrix metalloproteinase (MT1-MMP). Significantly higher FBI-1 protein and mRNA expression levels were demonstrated in ovarian cancers samples and cell lines compared with borderline tumors and benign cystadenomas. Increased FBI-1 mRNA expression was correlated significantly with gene amplification (P = 0.037). Moreover, higher FBI-1 expression was found in metastatic foci (P = 0.036) and malignant ascites (P = 0.021), and was significantly associated with advanced stage (P = 0.012), shorter overall survival (P = 0.032) and disease-free survival (P = 0.016). <it>In vitro</it>, overexpressed FBI-1 significantly enhanced cell migration and invasion both in OVCA 420 and SKOV-3 ovarian carcinoma cells, irrespective of <it>p53 </it>status, accompanied with elevated expression of MT1-MMP, but not MMP-2 or TIMP-2. Moreover, knockdown of MT1-MMP abolished FBI-1-mediated cell migration and invasion. Conversely, stable knockdown of FBI-1 remarkably reduced the motility of these cells with decreased expression of MT1-MMP. Promoter assay and chromatin immunoprecipitation study indicated that FBI-1 could directly interact with the promoter spanning ~600bp of the 5'-flanking sequence of MT1-MMP and enhanced its expression in a dose-dependent manner. Furthermore, stable knockdown and ectopic expression of FBI-1 decreased and increased cell proliferation respectively in OVCA 420, but not in the p53 null SKOV-3 cells.</p> <p>Conclusions</p> <p>Our results suggested an important role of FBI-1 in ovarian cancer cell proliferation, cell mobility, and invasiveness, and that FBI-1 can be a potential target of chemotherapy.</p

Oxygen Variability During ENSO in the Tropical South Eastern Pacific

The Oxygen Minimum Zone (OMZ) of the Tropical South Eastern Pacific (TSEP) is one of the most intensely deoxygenated water masses of the global ocean. It is strongly affected at interannual time scales by El Niño (EN) and La Niña (LN) due to its proximity to the equatorial Pacific. In this work, the physical and biogeochemical processes associated with the subsurface oxygen variability during EN and LN in the period 1958–2008 were studied using a regional coupled physical-biogeochemical model and in situ observations. The passage of intense remotely forced coastal trapped waves caused a strong deepening (shoaling) of the OMZ upper limit during EN (LN). A close correlation between the OMZ upper limit and thermocline depths was found close to the coast, highlighting the role of physical processes. The subsurface waters over the shelf and slope off central Peru had different origins depending on ENSO conditions. Offshore of the upwelling region (near 88°W), negative and positive oxygen subsurface anomalies were caused by Equatorial zonal circulation changes during LN and EN, respectively. The altered properties were then transported to the shelf and slope (above 200 m) by the Peru-Chile undercurrent. The source of nearshore oxygenated waters was located at 3°S−4°S during neutral periods, further north (1°S−1°N) during EN and further south (4°S−5°S) during LN. The offshore deeper (&lt;200–300 m) OMZ was ventilated by waters originating from ~8°S during EN and LN. Enhanced mesoscale variability during EN also impacted OMZ ventilation through horizontal and vertical eddy fluxes. The vertical eddy flux decreased due to the reduced vertical gradient of oxygen in the surface layer, whereas horizontal eddy fluxes injected more oxygen into the OMZ through its meridional boundaries. In subsurface layers, remineralization of organic matter, the main biogeochemical sink of oxygen, was higher during EN than during LN due to oxygenation of the surface layer. Sensitivity experiments highlighted the larger impact of equatorial remote forcing with respect to local wind forcing during EN and LN

The concentration of ethanol affects its penetration rate in bovine cardiac and hepatic tissues

Introduction. Ethanol is a commonly used fixative. Fixation of the inner layers of the tissue depends on the ability of the fixative to diffuse into the tissue. It is unknown whether the concentration of ethanol affects its penetration into tissues. This study aimed to compare the penetration rates of 50% and 100% ethanol into bovine heart and liver tissues. Materials and methods. The penetration distance and tissue shrinkage or expansion were measured by analysing the digital images of the heart and liver tissues before and after immersion in ethanol at 20°C for 2, 6, 24 or 30 hours. The penetration coefficients were calculated as the slope of the regression line using the linear regression function between the penetration distance and square root of fixation time. Differences in tissue shrinkage or expansion and penetration distance at various time points between the two concentrations of ethanol were analysed using a mixed design ANOVA followed by Bonferroni’s post-hoc test. Results. The penetration distance of 100% ethanol was significantly greater in both heart and liver tissues compared with that of 50% ethanol (n = 4, p < 0.05 for both). 100% ethanol shrank immersed liver tissue significantly more than 50% ethanol (p = 0.002), but the shrinkage of the heart tissue caused by two concentrations of ethanol did not significantly differ (p = 0.054). The greater penetration distance of 100% over 50% ethanol remained unchanged after normalising the penetration distance to the individual tissue’s shrinkage (n = 4, p < 0.001). The mean penetration coefficient of 100% ethanol was significantly greater than 50% ethanol in the heart tissue (0.906 vs. 0.442, p = 0.003) and in the liver tissue (0.988 vs. 0.622, p = 0.028). Conclusions. It was proven that in two types of tissue that substantially differ in histological structures, 100% ethanol penetrated tissue significantly faster than 50% ethanol