A general construction for monoid-based knapsack protocols

We present a generalized version of the knapsack protocol proposed by D. Naccache and J. Stern at the Proceedings of Eurocrypt (1997). Our new framework will allow the construction of other knapsack protocols having similar security features. We will outline a very concrete example of a new protocol using extension fields of a finite field of small characteristic instead of the prime field Z/pZ, but more efficient in terms of computational costs for asymptotically equal information rate and similar key size.Comment: 18 pages, to appear on Advances in Mathematics of Communication

Regular Fabric Design with Ambipolar CNTFETs for FPGA and Structured ASIC Applications

In this paper, we propose for the first time the application of ambipolar CNTFETs with in-field controllable polarities to design regular fabrics with static logic. We exploit the high expressive power provided by complementary static logic built with ambipolar CNTFETs to design compact and efficient configurable gates. After evaluating a polarity-aware logic design for the configurable gates, we selected a number of gates with an And-Or-Inverter structure and produced a first comparison with existent medium-grained logic blocks, like the Actel ACT1 and 4-input LUTs [1]. Preliminary evaluation of our gates indicates improvements of around 47% over the ACT1 and of about 18× with respect to 4-input LUTs in terms of area×normalized delay

Methods for Designing Reliable Probe Arrays

Recent advances in biosensing technologies have led to applications of biosensor probe arrays for rapid identification of biological agents such as drugs, gene expressions, proteins, cholesterol and fats in an input sample. However, monitoring the simultaneous presence of multiple agents in a sample is still a challenging task. Multiple agents may often attach to the same probes, leading to low specificity. By using microarrays as a specific example, we introduce two methods based on conditional deduction and non-unique probes to detect multiple targets. We introduce three quality metrics, namely: effectiveness, cost and reliability to evaluate different designs of microarrays and propose two ILP/Pseudo-Boolean models for optimizing on these metrics. By applying on various synthetic and real datasets, we demonstrate the importance of these quality metrics in designing microarrays for multiple target detections

Alternative Design Methodologies for the Next Generation Logic Switch (invited paper)

Next generation logic switch devices are ex- pected to rely on radically new technologies mainly due to the increasing difficulties and limitations of state-of-the-art CMOS switches, which, in turn, will also require innovative design methodologies that are distinctly different from those used for CMOS technologies. In this paper, three alternative emerging technologies are showcased in terms of their re- quirements for design implementation and in terms of poten- tial advantages. First, a CMOS evolutionary approach based on vertically-stacked gate-all-around Si nanowire FETs is discussed. Next, an alternative design methodology based on ambipolar carbon nanotube FETs is presented. Finally, a novel approach based on the recently discovered memristive devices is presented, offering the possibility of combining memory and logic functions

Quantum Dot-Based Screening Identifies F3 Peptide and Reveals Cell Surface Nucleolin as a Therapeutic Target for Rhabdomyosarcoma.

Active drug delivery by tumor-targeting peptides is a promising approach to improve existing therapies for rhabdomyosarcoma (RMS), by increasing the therapeutic effect and decreasing the systemic toxicity, e.g., by drug-loaded peptide-targeted nanoparticles. Here, we tested 20 different tumor-targeting peptides for their ability to bind to two RMS cell lines, Rh30 and RD, using quantum dots Streptavidin and biotin-peptides conjugates as a model for nanoparticles. Four peptides revealed a very strong binding to RMS cells: NCAM-1-targeting NTP peptide, nucleolin-targeting F3 peptide, and two Furin-targeting peptides, TmR and shTmR. F3 peptide showed the strongest binding to all RMS cell lines tested, low binding to normal control myoblasts and fibroblasts, and efficient internalization into RMS cells demonstrated by the cytoplasmic delivery of the Saporin toxin. The expression of the nucleophosphoprotein nucleolin, the target of F3, on the surface of RMS cell lines was validated by competition with the natural ligand lactoferrin, by colocalization with the nucleolin-binding aptamer AS1411, and by the marked sensitivity of RMS cell lines to the growth inhibitory nucleolin-binding N6L pseudopeptide. Taken together, our results indicate that nucleolin-targeting by F3 peptide represents a potential therapeutic approach for RMS

Physical Synthesis onto Sea-of-Tiles with Double-Gate Silicon Nanowire Transistors

We have designed and fabricated double-gate ambipolar field-effect transistors, which exhibit p-type and n-type characteristics by controlling the polarity of the second gate. In this work, we present an approach for designing an efficient regular layout, called Sea-of-Tiles (SoTs). First, we address gate-level routing congestion by proposing compact layout techniques and novel symbolic-layout styles. Second, we design four logic tiles, which form the basic building block of the SoT fabric. We run extensive comparisons of mapping standard benchmarks on the SoT. Our study shows that SoT with Tile(G2) and TileG(1h2), on an average, outperforms the one with Tile(G1) and Tile(G3) by 16% and 10% in area utilization, respectively

A Schottky-Barrier Silicon FinFET with 6.0 mV/dec Subthreshold Slope over 5 Decades of Current

In this paper, we demonstrate a steep Subthreshold Slope (SS) silicon FinFET with Schottky-barrier source/drain. The device shows a minimal SS of 3.4 mV/dec and an average SS of 6.0 mV/dec over 5 decades of current swing. Ultra-low leakage floor of 0.06 pA/μm is also achieved with high Ion/Ioff ratio of 107

Towards Functionality-Enhanced Devices: Controlling the Modes of Operation in Three-Independent-Gate Transistors

In this paper, we introduce the different modes of operation achievable with Three-Independent-Gate Field-Effect Transistors (TIGFETs) and report results on fabricated devices including: (i) the dynamic reconfiguration of the device polarity; (ii) the dynamic control of the threshold voltage; and (iii) the dynamic control of the subthreshold slope

Interoperability Among Unmanned Maritime Vehicles: Review and First In-field Experimentation

Complex maritime missions, both above and below the surface, have traditionally been carried out by manned surface ships and submarines equipped with advanced sensor systems. Unmanned Maritime Vehicles (UMVs) are increasingly demonstrating their potential for improving existing naval capabilities due to their rapid deployability, easy scalability, and high reconfigurability, offering a reduction in both operational time and cost. In addition, they mitigate the risk to personnel by leaving the man far-from-the-risk but in-the-loop of decision making. In the long-term, a clear interoperability framework between unmanned systems, human operators, and legacy platforms will be crucial for effective joint operations planning and execution. However, the present multi-vendor multi-protocol solutions in multi-domain UMVs activities are hard to interoperate without common mission control interfaces and communication protocol schemes. Furthermore, the underwater domain presents significant challenges that cannot be satisfied with the solutions developed for terrestrial networks. In this paper, the interoperability topic is discussed blending a review of the technological growth from 2000 onwards with recent authors' in-field experience; finally, important research directions for the future are given. Within the broad framework of interoperability in general, the paper focuses on the aspect of interoperability among UMVs not neglecting the role of the human operator in the loop. The picture emerging from the review demonstrates that interoperability is currently receiving a high level of attention with a great and diverse deal of effort. Besides, the manuscript describes the experience from a sea trial exercise, where interoperability has been demonstrated by integrating heterogeneous autonomous UMVs into the NATO Centre for Maritime Research and Experimentation (CMRE) network, using different robotic middlewares and acoustic modem technologies to implement a multistatic active sonar system. A perspective for the interoperability in marine robotics missions emerges in the paper, through a discussion of current capabilities, in-field experience and future advanced technologies unique to UMVs. Nonetheless, their application spread is slowed down by the lack of human confidence. In fact, an interoperable system-of-systems of autonomous UMVs will require operators involved only at a supervisory level. As trust develops, endorsed by stable and mature interoperability, human monitoring will be diminished to exploit the tremendous potential of fully autonomous UMVs

The splitting of double-component active asteroid P/2016 J1 (PANSTARRS)

We present deep imaging observations, orbital dynamics, and dust tail model analyses of the double-component asteroid P/2016 J1 (J1-A and J1-B). The observations were acquired at the Gran Telescopio Canarias (GTC) and the Canada-France-Hawaii Telescope (CFHT) from mid March to late July, 2016. A statistical analysis of backward-in-time integrations of the orbits of a large sample of clone objects of P/2016 J1-A and J1-B shows that the minimum separation between them occurred most likely $\sim$2300 days prior to the current perihelion passage, i.e., during the previous orbit near perihelion. This closest approach was probably linked to a fragmentation event of their parent body. Monte Carlo dust tail models show that those two components became active simultaneously $\sim$250 days before the current perihelion, with comparable maximum loss rates of $\sim$0.7 kg s$^{-1}$ and $\sim$0.5 kg s$^{-1}$, and total ejected masses of 8$\times$10$^{6}$ kg and 6$\times$10$^{6}$ kg for fragments J1-A and J1-B, respectively. In consequence, the fragmentation event and the present dust activity are unrelated. The simultaneous activation times of the two components and the fact that the activity lasted 6 to 9 months or longer, strongly indicate ice sublimation as the most likely mechanism involved in the dust emission process.Comment: Accepted by ApJ Letters, Feb. 17, 201