General Relativistic Flux Modulations from Disk Instabilities in Sagittarius A*

Near-IR and X-ray flares have been detected from the supermassive black hole Sgr A* at the center of our Galaxy with a (quasi)-period of ~17-20 minutes, suggesting an emission region only a few Schwarzschild radii above the event horizon. The latest X-ray flare, detected with XMM-Newton, is notable for its detailed lightcurve, yielding not only the highest quality period thus far, but also important structure reflecting the geometry of the emitting region. Recent MHD simulations of Sgr A*'s disk have demonstrated the growth of a Rossby wave instability, that enhances the accretion rate for several hours, possibly accounting for the observed flares. In this Letter, we carry out ray-tracing calculations in a Schwarzschild metric to determine as accurately as possible the lightcurve produced by general relativistic effects during such a disruption. We find that the Rossby wave induced spiral pattern in the disk is an excellent fit to the data, implying a disk inclination angle of ~77 deg. Note, however, that if this association is correct, the observed period is not due to the underlying Keplerian motion but, rather, to the pattern speed. The favorable comparison between the observed and simulated lightcurves provides important additional evidence that the flares are produced in Sgr A*'s inner disk.Comment: 5 Pages, 3 Figures, accepted for publication in ApJ Lette

Positrons and antiprotons from inert doublet model dark matter

In the framework of the Inert Doublet Model, a very simple extension of the Standard Model, we study the production and propagation of antimatter in cosmic rays coming from annihilation of a scalar dark matter particle. We consider three benchmark candidates, all consistent with the WMAP cosmic abundance and existing direct detection experiments, and confront the predictions of the model with the recent PAMELA, ATIC and HESS data. For a light candidate, M_{DM} = 10 GeV, we argue that the positron and anti-proton fluxes may be large, but still consistent with expected backgrounds, unless there is an enhancement (boost factor) in the local density of dark matter. There is also a substantial anti-deuteron flux which might be observable by future experiments. For a candidate with M_{DM} = 70 GeV, the contribution to positron and anti-proton fluxes is much smaller than the expected backgrounds. Even if a boost factor is invoked to enhance the signals, the candidate is unable to explain the observed positron and anti-proton excesses. Finally, for a heavy candidate, M_{DM} = 10 TeV, it is possible to fit the PAMELA excess (but, unfortunately, not the ATIC one) provided there is a large enhancement, either in the local density of dark matter or through the Sommerfeld effect.Comment: 17 pages ; v2: matches JCAP published versio

Leukotrienes inhibit early stages of HIV-1 infection in monocyte-derived microglia-like cells

<p>Abstract</p> <p>Background</p> <p>Microglia are one of the main cell types to be productively infected by HIV-1 in the central nervous system (CNS). Leukotriene B₄(LTB₄) and cysteinyl-leukotrienes such as LTC₄are some of the proinflammatory molecules produced in infected individuals that contribute to neuroinflammation. We therefore sought to investigate the role of leukotrienes (LTs) in HIV-1 infection of microglial cells.</p> <p>Methods</p> <p>To evaluate the role of LTs on HIV-1 infection in the CNS, monocyte-derived microglial-like cells (MDMis) were utilized in this study. Leukotriene-treated MDMis were infected with either fully replicative brain-derived HIV-1 isolates (YU2) or R5-tropic luciferase-encoding particles in order to assess viral production and expression. The efficacy of various steps of the replication cycle was evaluated by means of p24 quantification by ELISA, luciferase activity determination and quantitative real-time polymerase chain reaction (RT-PCR).</p> <p>Results</p> <p>We report in this study that virus replication is reduced upon treatment of MDMis with LTB₄and LTC₄. Additional experiments indicate that these proinflammatory molecules alter the pH-independent entry and early post-fusion events of the viral life cycle. Indeed, LT treatment induced a diminution in integrated proviral DNA while reverse-transcribed viral products remained unaffected. Furthermore, decreased C-C chemokine receptor type 5 (CCR5) surface expression was observed in LT-treated MDMis. Finally, the effect of LTs on HIV-1 infection in MDMis appears to be mediated partly via a signal transduction pathway involving protein kinase C.</p> <p>Conclusions</p> <p>These data show for the first time that LTs influence microglial cell infection by HIV-1, and may be a factor in the control of viral load in the CNS.</p

A compilation of global bio-optical in situ data for ocean colour satellite applications – version three

A global in situ data set for validation of ocean colour products from the ESA Ocean Colour Climate Change Initiative (OC-CCI) is presented. This version of the compilation, starting in 1997, now extends to 2021, which is important for the validation of the most recent satellite optical sensors such as Sentinel 3B OLCI and NOAA-20 VIIRS. The data set comprises in situ observations of the following variables: spectral remote-sensing reflectance, concentration of chlorophyll-a, spectral inherent optical properties, spectral diffuse attenuation coefficient, and total suspended matter. Data were obtained from multi-project archives acquired via open internet services or from individual projects acquired directly from data providers. Methodologies were implemented for homogenization, quality control, and merging of all data. Minimal changes were made on the original data, other than conversion to a standard format, elimination of some points, after quality control and averaging of observations that were close in time and space. The result is a merged table available in text format. Overall, the size of the data set grew with 148 432 rows, with each row representing a unique station in space and time (cf. 136 250 rows in previous version; Valente et al., 2019). Observations of remote-sensing reflectance increased to 68 641 (cf. 59 781 in previous version; Valente et al., 2019). There was also a near tenfold increase in chlorophyll data since 2016. Metadata of each in situ measurement (original source, cruise or experiment, principal investigator) are included in the final table. By making the metadata available, provenance is better documented and it is also possible to analyse each set of data separately. The compiled data are available at https://doi.org/10.1594/PANGAEA.941318 (Valente et al., 2022)

Predicting Residual Rectal Adenocarcinoma in the Surgical Specimen after Preoperative Brachytherapy with Endoscopic Ultrasound

BACKGROUND AND STUDY AIMS: A novel brachytherapy (BT) protocol evaluated at McGill University has shown promise in terms of downstaging and achieving high tumour sterilization rates in rectal cancer. Endoscopic ultrasound (EUS) has emerged as the imaging modality of choice for local staging of rectal cancer. However, external beam radiotherapy appears to decrease the accuracy of EUS from 85% to 40%. The aim of the present study was to prospectively evaluate the accuracy of EUS in assessing the response of rectal cancer to BT