Proceedings of the 21th International Configuration Workshop

International audienc

Asymptotic expansions in the conditional central limit theorem

AbstractLet Xn, n∈N, be i.i.d. with mean 0, variance 1, and E(¦Xn¦r) < ∞ for some r ⩾ 3. Assume that Cramér's condition is fulfilled. We prove that the conditional probabilities P(1√n Σi = 1n Xi ⩽ t¦B) can be approximated by a modified Edgeworth expansion up to order o(1n(r − 2)2)), if the distances of the set B from the σ-fields σ(X1, …, Xn) are of order O(1n(r − 2)2)(lg n)β), where β < −(r − 2)2 for r∉N and β < −r2 for r∈N. An example shows that if we replace β < −(r − 2)2 by β = −(r − 2)2 for r∉N(β < −r2 by β = −r2 for r∈N) we can only obtain the approximation order O(1n(r − 2)2)) for r∉N(O(lg lgnn(r − 2)2)) for r∈N)

Nuclear physics for geo-neutrino studies

Geo-neutrino studies are based on theoretical estimates of geo-neutrino spectra. We propose a method for a direct measurement of the energy distribution of antineutrinos from decays of long-lived radioactive isotopes. We present preliminary results for the geo-neutrinos from Bi-214 decay, a process which accounts for about one half of the total geo-neutrino signal. The feeding probability of the lowest state of Bi-214 - the most important for geo-neutrino signal - is found to be p_0 = 0.177 \pm 0.004 (stat) ^{+0.003}_{-0.001} (sys), under the hypothesis of Universal Neutrino Spectrum Shape (UNSS). This value is consistent with the (indirect) estimate of the Table of Isotopes (ToI). We show that achievable larger statistics and reduction of systematics should allow to test possible distortions of the neutrino spectrum from that predicted using the UNSS hypothesis. Implications on the geo-neutrino signal are discussed.Comment: 8 pages RevTex format, 8 figures and 2 tables. Submitted to PR

Application of Noise Certification Regulations within Conceptual Aircraft Design

ICAO Annex 16 regulations are used to certify the acoustic performance of subsonic transport aircraft. Each aircraft is classified according to the measured EPNL levels at specific certification locations along the approach and departure. By simulating this certification process, it becomes possible to identify all relevant parameters and assess promising measures to reduce the noise certification levels in compliance with the underlying ICAO regulations, i.e., allowable operating conditions of the aircraft. Furthermore, simulation is the only way to enable an assessment of novel technology and non-existing vehicle concepts, which is the main motivation behind the presented research activities. Consequently, the ICAO Annex 16 regulations are integrated into an existing noise simulation framework at DLR, and the virtual noise certification of novel aircraft concepts is realized at the conceptual design phase. The predicted certification levels can be directly selected as design objectives in order to realize an advantageous ICAO noise category for a new aircraft design, i.e., simultaneously accounting for the design and the resulting flight performance. A detailed assessment and identification of operational limits and allowable flight procedures for each conceptual aircraft design under consideration is enabled. Sensitivity studies can be performed for the relevant input parameters that influence the predicted noise certification levels. Specific noise sources with a dominating impact on the certification noise levels can be identified, and promising additional low-noise measures can be applied within the conceptual design phase. The overall simulation process is applied to existing vehicles in order to assess the validity of the simulation results compared to published data. Thereafter, the process is applied to some DLR low-noise aircraft concepts to evaluate their noise certification levels. These results can then be compared to other standard noise metrics that are typically applied in order to describe aircraft noise, e.g., SEL isocontour areas. It can be demonstrated that certain technologies can significantly reduce the noise impact along most of an approach or departure flight track but have only a limited influence on the noise certification levels and vice versa. Finally, an outlook of the ongoing developments is provided, in order to apply the new simulation process to supersonic aircraft. Newly proposed regulations for such concepts are implemented into the process in order to evaluate these new regulations and enable direct comparison with existing regulations

Geteiltes Wissen und Retrieval: Ein Prozessmodell zur Unterstützung kollaborativer Suchprozesse

Hoher Wettbewerbsdruck wird für Unternehmen auf allen Ebenen immer stärker spürbar. Noch vor einigen Jahren gab es ganze Bereiche in Wirtschaft, Handel und öffentlicher Verwaltung, die bestenfalls auf eine technisch-inhaltliche Optimierung der jeweiligen Produkte und Leistungen orientiert waren. Dies hat weitgehend einer markt- und wettbewerbsorientierten Ausrichtung Platz gemacht, Innensicht wird durch verstärkte Außensicht ergänzt

Simulation of Landing and Take-off Noise for Supersonic Transport Aircraft at a Conceptual Design Fidelity Level

The German Aerospace Center has launched an internal project to assess the noise impact associated with supersonic transport aircraft during approach and departure. A dedicated simulation process is established to cover all relevant disciplines, i.e., aircraft and engine design, engine installation effects, flight simulation, and system noise prediction. The core of the simulation process is comprised of methods at the complexity and fidelity level of conceptual aircraft design, i.e., typical overall aircraft design methods and a semi-empirical approach for the noise modeling. Dedicated interfaces allow to process data from high fidelity simulation that will support or even replace initial low fidelity results in the long run. All of the results shown and discussed in this study are limited to the fidelity level of conceptual design. The application of the simulation process to the NASA 55t Supersonic Technology Concept Aeroplane, i.e., based on non-proprietary data for this vehicle, yields similar noise level predictions when compared to the published NASA results. This is used as an initial feasibility check of the new process and confirms the underlying methods and models. Such an initial verification of the process is understood as an essential step due to the lack of available noise data for supersonic transport aircraft in general. The advantageous effect of engine noise shielding on the resulting system noise is demonstrated based on predicted level time histories and certification noise levels. After this initial verification, the process is applied to evaluate a conceptual supersonic transport design based on a PhD thesis with two engines mounted under the wing, which is referred to as aircraft TWO. Full access to this vehicle’s design and performance data allows to investigate the influence of flight procedures on the resulting noise impact along approach and departure. These noise results are then assembled according to proposed Federal Aviation Agency regulations in their Notice of Proposed Rulemaking, e.g., speed limitations, for Supersonic transport noise certification and the regulations from Noise Chapters of the Annex 16 from the International Civil Aviation Organization in order to evaluate the resulting levels as a function of the flight procedure

Seroepidemiological study on the spread of SARS-CoV-2 in Germany:

The SARS-CoV-2 coronavirus has spread rapidly across Germany. Infections are likely to be under-recorded in the notification data from local health authorities on laboratory-confirmed cases since SARS-CoV-2 infections can proceed with few symptoms and then often remain undetected. Seroepidemiological studies allow the estimation of the proportion in the population that has been infected with SARS-CoV-2 (seroprevalence) as well as the extent of undetected infections. The ‘CORONA-MONITORING bundesweit’ study (RKI-SOEP study) collects biospecimens and interview data in a nationwide population sample drawn from the German Socio-Economic Panel (SOEP). Participants are sent materials to self-collect a dry blood sample of capillary blood from their finger and a swab sample from their mouth and nose, as well as a questionnaire. The samples returned are tested for SARS-CoV-2 IgG antibodies and SARS-CoV-2 RNA to identify past or present infections. The methods applied enable the identification of SARS-CoV-2 infections, including those that previously went undetected. In addition, by linking the data collected with available SOEP data, the study has the potential to investigate social and health-related differences in infection status. Thus, the study contributes to an improved understanding of the extent of the epidemic in Germany, as well as identification of target groups for infection protection

Clostridioides difficile Activates Human Mucosal-Associated Invariant T Cells

Clostridioides difficile infection (CDI) causes severe inflammatory responses at the intestinal mucosa but the immunological mechanisms underlying CDI-related immunopathology are still incompletely characterized. Here we identified for the first time that both, non-toxigenic strains as well as the hypervirulent ribotypes RT027 and RT023 of Clostridioides difficile (formerly Clostridium difficile), induced an effector phenotype in mucosal-associated invariant T (MAIT) cells. MAIT cells can directly respond to bacterial infections by recognizing MR1-presented metabolites derived from the riboflavin synthesis pathway constituting a novel class of antigens. We confirmed functional riboflavin synthesis of C. difficile and found fixed bacteria capable of activating primary human MAIT cells in a dose-dependent manner. C. difficile-activated MAIT cells showed an increased and MR1-dependent expression of CD69, proinflammatory IFNγ, and the lytic granule components granzyme B and perforin. Effector protein expression was accompanied by the release of lytic granules, which, in contrast to other effector functions, was mainly induced by IL-12 and IL-18. Notably, this study revealed hypervirulent C. difficile strains to be most competent in provoking MAIT cell responses suggesting MAIT cell activation to be instrumental for the immunopathology observed in C. difficile-associated colitis. In conclusion, we provide first evidence for a link between C. difficile metabolism and innate T cell-mediated immunity in humans

SARS-CoV-2 Transmissibility Within Day Care Centers—Study Protocol of a Prospective Analysis of Outbreaks in Germany

Introduction: Until today, the role of children in the transmission dynamics of SARS-CoV-2 and the development of the COVID-19 pandemic seems to be dynamic and is not finally resolved. The primary aim of this study is to investigate the transmission dynamics of SARS-CoV-2 in child day care centers and connected households as well as transmission-related indicators and clinical symptoms among children and adults. Methods and Analysis: COALA (“Corona outbreak-related examinations in day care centers”) is a day care center- and household-based study with a case-ascertained study design. Based on day care centers with at least one reported case of SARS-CoV-2, we include one- to six-year-old children and staff of the affected group in the day care center as well as their respective households. We visit each child's and adult's household. During the home visit we take from each household member a combined mouth and nose swab as well as a saliva sample for analysis of SARS-CoV-2-RNA by real-time reverse transcription polymerase chain reaction (real-time RT-PCR) and a capillary blood sample for a retrospective assessment of an earlier SARS-CoV-2 infection. Furthermore, information on health status, socio-demographics and COVID-19 protective measures are collected via a short telephone interview in the subsequent days. In the following 12 days, household members (or parents for their children) self-collect the same respiratory samples as described above every 3 days and a stool sample for children once. COVID-19 symptoms are documented daily in a symptom diary. Approximately 35 days after testing the index case, every participant who tested positive for SARS-CoV-2 during the study is re-visited at home for another capillary blood sample and a standardized interview. The analysis includes secondary attack rates, by age of primary case, both in the day care center and in households, as well as viral shedding dynamics, including the beginning of shedding relative to symptom onset and viral clearance. Discussion: The results contribute to a better understanding of the epidemiological and virological transmission-related indicators of SARS-CoV-2 among young children, as compared to adults and the interplay between day care and households.Peer Reviewe