10 research outputs found

    Air quality low-cost sensors and monitoring stations NO2 raw dataset in Rouen (France)

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    This article presents a dataset comprising measurements made by co-located devices, with the aim of calibrating sensors for an upcoming in-situ use. The dataset includes hourly averaged data from 9 low-cost sensors and 2 traffic monitoring stations (thereafter named QDP and SUD3) in Rouen spanning from October 20, 2021 to March 25, 2022. In addition, the dataset is enriched by covariates measured by the sensors: temperature, relative humidity, atmospheric pressure, plus Ox and CO measures.The experiment was conducted as part of TIGA1‘s call for project, and designed to have a better understanding of sensors’ drawbacks, particularly when they are moved or shut down. Knowledge about the effect of air pollution on health has gained significant attention from both the scientific community and citizens, making air quality a growing issue for urban area. As a result, the city of Rouen in Normandy, France, has prioritized air quality monitoring as a key initiative. Concurrently, several means to measure air pollutants have been made more accessible, such as the use of low-cost sensors. Those sensors offer affordability, but are known to be less accurate than monitoring stations. Thus, they need to be cautiously studied so as to be used properly

    Représentativité spatiale d'une station de mesure de la pollution atmosphérique - Spatial representativeness of an air pollution measurement

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    International audienceLa notion de représentativité est mentionnée dans de nombreux textes législatifs sur la qualité de lʼair. Une définition de la représentativité spatiale dʼune station de mesure de la pollution de lʼair par le dioxyde dʼazote est proposée et testée sur lʼagglomération rouennaise pour lʼannée 2005. Partant dʼune notion empirique – une station de mesure est représentative dʼun point géographique si les concentrations en ces deux sites sont « suffisamment proches » – nous proposons une formalisation mathématique de la représentativité. La technique du krigeage permet de ramener le problème de la délimitation de la zone de représentativité dʼune station à la majoration dʼune somme de deux termes : le premier est lʼécart entre la moyenne annuelle de la concentration mesurée à la station et son estimation par krigeage au point courant, le second fait intervenir lʼécart-type de lʼerreur dʼestimation. La mise en oeuvre pratique fournit la zone de représentativité de chaque station. Certaines de ces zones peuvent se chevaucher ; en tout point des zones de recouvrement, on détermine alors la station la plus représentative. Enfin, la notion de représentativité est examinée en relation avec la probabilité de dépassement dʼun seuil fix

    Effect of Cyclosporine in Nonshockable Out-of-Hospital Cardiac Arrest: The CYRUS Randomized Clinical Trial

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    International audienceIMPORTANCE: Experimental evidence suggests that cyclosporine prevents postcardiac arrest syndrome by attenuating the systemic ischemia reperfusion response. OBJECTIVE: To determine whether early administration of cyclosporine at the time of resuscitation in patients with out-of-hospital cardiac arrest (OHCA) would prevent multiple organ failure. DESIGN, SETTING, AND PARTICIPANTS: A multicenter, single-blind, randomized clinical trial was conducted from June 22, 2010, to March 13, 2013 (Cyclosporine A in Out-of-Hospital Cardiac Arrest Resuscitation [CYRUS]). Sixteen intensive care units in 7 university-affiliated hospitals and 9 general hospitals in France participated. A total of 6758 patients who experienced nonshockable OHCA (ie, asystole or pulseless electrical activity) were assessed for eligibility. Analyses were performed according to the intention-to-treat analysis. INTERVENTIONS: Patients received an intravenous bolus injection of cyclosporine, 2.5 mg/kg, at the onset of advanced cardiovascular life support (cyclosporine group) or no additional intervention (control group). MAIN OUTCOMES AND MEASURES: The primary end point was the Sequential Organ Failure Assessment (SOFA) score, assessed 24 hours after hospital admission, which ranges from 0 to 24 (with higher scores indicating more severe organ failure). Secondary end points included survival at 24 hours, hospital discharge, and favorable neurologic outcome at discharge. RESULTS: Of the 6758 patients screened, 794 were included in intention-to-treat analysis (cyclosporine, 400; control, 394). The median (interquartile range [IQR]) ages were 63.0 (54.0-71.8) years for the cyclosporine group and 66.0 (57.0-74.0) years for the control group. The cohorts included 293 men (73.3%) in the treatment group and 288 men (73.1%) in the control group. At 24 hours after hospital admission, the SOFA score was not significantly different between the cyclosporine (median, 10.0; IQR, 7.0-13.0) and the control (median, 11.0; IQR, 7.0-15.0) groups. Survival was not significantly different between the 98 (24.5%) cyclosporine vs 101 (25.6%) control patients at hospital admission (adjusted odds ratio [aOR], 0.94; 95% CI, 0.66-1.34), at 24 hours for 67 (16.8%) vs 62 (15.7%) patients (aOR, 1.08; 95% CI, 0.71-1.63), and at hospital discharge for 10 (2.5%) vs 5 (1.3%) patients (aOR, 2.00; 95% CI, 0.61-6.52). Favorable neurologic outcome at discharge was comparable between the cyclosporine and control groups: 7 (1.8%) vs 5 (1.3%) patients (aOR, 1.39; 95% CI, 0.39-4.91). CONCLUSION AND RELEVANCE: In patients presenting with nonshockable cardiac rhythm after OHCA, cyclosporine does not prevent early multiple organ failure. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01595958; EudraCT Identifier: 2009-015725-37
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