Recurrent sores by ill-fitting dentures and intra-oral squamous cell carcinoma in smokers

Objectives: To examine whether denture use and recurrent sores caused by ill-fitting dentures are associated with intra-oral squamous cell carcinoma (IO-SCC) in individuals exposed to tobacco. Methods: We conducted a hospital-based case-control study. The study population comprised 124 patients with IO-SCC and the same number of controls (individually paired according to gender and age) recruited from outpatient units of the same hospital. Conditional logistic regression analysis assessed the effect of denture use and recurrent oral sores by ill-fitting dentures, adjusted by covariates on the lifetime exposure to alcohol and tobacco, socioeconomic standings, and dietary patterns. Results: The use of dentures showed no association with IO-SCC [adjusted odds ratio (OR) 1.40, 95 percent confidence interval 0.51-3.87, P = 0.513] in an assessment controlled by socioeconomic position, lifetime exposure to alcohol and tobacco, and dietary patterns. However, the report of recurrent sores caused by ill-fitting dentures showed significant association with the disease (adjusted OR 4.58, 95 percent confidence interval 1.52-13.76, P = 0.007). Conclusions: The association between recurrent oral sores caused by ill-fitting dentures and squamous cell carcinoma of the mouth in smokers is in agreement with the hypothesis that the chronic physical irritation of oral mucosa contributes to the topical carcinogenic effect of tobacco, which must be taken into careful consideration in the planning of dental services for adults and the elderly.Foundation for the Support of Research in the State of Sao Paulo (FAPESP)[05/03367-6

Human papillomavirus (HPV) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of HPV infection

The role of human papillomavirus (HPV) on head and neck squamous cell carcinoma (HNSCC) survival in regions with low HPV prevalence is not yet clear. We evaluated the HPV16 infection on survival of HNSCC Brazilian patient series.This cohort comprised 1,093 HNSCC cases recruited from 1998 to 2008 in four Brazilian cities and followed up until June 2009. HPV16 antibodies were analyzed by multiplex Luminex assay. in a subset of 398 fresh frozen or paraffin blocks of HNSCC specimens, we analyzed for HPV16 DNA by L1 generic primer polymerase chain reaction. HNSCC survival according to HPV16 antibodies was evaluated through Kaplan-Meier method and Cox regression.Prevalence of HPV16 E6 and E6/E7 antibodies was higher in oropharyngeal cancer than in other head and neck tumor sites. HPV16 DNA positive in tumor tissue was also higher in the oropharynx. Seropositivity for HPV16 E6 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer. the presence of HPV16 E6/E7 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer survival. the death risk of oropharyngeal squamous cell carcinoma patients HPV16 E6/E7 antibodies positive was 78 % lower than to those who test negative.Oropharyngeal squamous cell carcinoma is less aggressive in the HPV16 E6/E7 positive serology patients. HPV16 E6/E7 antibody is a clinically sensible surrogate prognostic marker of oropharyngeal squamous cell carcinoma.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)European CommissionUniv São Paulo, Fac Saude Publ, BR-01246904 São Paulo, BrazilHosp Canc Barretos, Inst Ensino & Pesquisa, Barretos, BrazilUniv São Paulo, Inst Med Trop, BR-01246904 São Paulo, BrazilUniv São Paulo, Fac Med, BR-01246904 São Paulo, BrazilFundacao Oswaldo Cruz, Escola Nacl Saude Publ, Rio de Janeiro, BrazilHosp Araujo Jorge, Goiania, BrazilInt Prevent Res Inst, Lyon, FranceUniv São Paulo, Fac Med, Hosp Clin, BR-01246904 São Paulo, BrazilUniv São Paulo, Fac Med Ribeirao Preto, Hosp Clin, BR-14049 Ribeirao Preto, BrazilHosp Heliopolis, São Paulo, BrazilHosp Canc AC Camargo, São Paulo, BrazilUniversidade Federal de São Paulo, Hosp São Paulo, São Paulo, BrazilInst Canc Arnaldo Viera Carvalho, São Paulo, BrazilFac Med Sao Jose Rio Preto, São Paulo, BrazilGerman Canc Res Ctr, Heidelberg, GermanyMt Sinai Sch Med, Tisch Canc Inst, New York, NY USAInt Agcy Res Canc, F-69372 Lyon, FranceUniversidade Federal de São Paulo, Hosp São Paulo, São Paulo, BrazilFAPESP: 10/50733-6FAPESP: 09/52031-1FAPESP: 04/12054-9European Commission: IC18-CT97-0222Web of Scienc