Revised proposal for encoding the Linear A script in the SMP of the UCS

This is a proposal to encode the Linear A script in the international character encoding standard Unicode. This script was published in Unicode Standard version 7.0 in June 2014. Linear A was used on Crete and surrounding areas and dates from approximately 1700 to 1450 BCE. The script was used to write a language that has not yet been securely identified

Direct Use of Low Enthalpy Deep Geothermal Resources in the East African Rift Valley

Geothermal energy is already harnessed across East Africa to provide hundreds of megawatts of electricity, with significant plans for future expansion towards generation at the gigawatt scale. This power generation utilizes the high steam temperatures (typically more than 200 °C) that are available in several locations in Kenya, Ethiopia and elsewhere. The presence of these high enthalpy resources has deflected attention from the often attractive low and medium enthalpy resources present across a more extensive portion of the region. Geothermally heated water at cooler temperatures (less than 90 °C) could be widely produced by drilling shallower and cheaper boreholes than those required for power production. This low enthalpy resource could be widely exploitable throughout the Rift Valley, offering a low carbon, sustainable, reliable and commercially competitive source of heating, drying and cooling (via absorption chillers) to local farmers and growers, and for low temperature commercial and industrial uses. Applications of this type would displace expensive fossil fuels, reducing costs and carbon emissions as well as improving the region’s energy and food security. The power input for pump systems can be accommodated by relatively small generators, so direct heat projects could be beneficial to consumers in areas with no grid access

Investigating the Knowledge Surrounding Folate and Folic Acid in a Cohort of Vegetarians

BackgroundThe aim is to identify any gaps in the knowledge of folate and folic acid in vegetarians, which is of interest given the increasing adoption of vegetarian type diets. MethodsIn this convenience sample, 106 people answered an online questionnaire regarding folate intake and awareness among vegetarians. This was created using Google Forms and was shared via Facebook, including on various national and college vegetarian group pages. There were 44 questions. Twenty-four participants were excluded, because they reported eating fish, chicken or other meat. Final data analysis included 82 subjects. The majority of these vegetarians were females over the age of 30. ResultsFifty-five percent of those aged23% of those \u3e30, did not know the recommended stage for folic acid supplementation. Thirty-four percent of females, did not know any good food sources of folate compared to 67% of males. ConclusionsThere was an overall lack of knowledge regarding the recommended stage for folic acid intake and the required quantity of folic acid to be taken among vegetarians. This research suggests that more public health campaigns are needed in order to increase the knowledge and intake of folic acid

Selection of misfolded CFTR for proteasomal degradation by sequential Quality Control checkpoints

CFTR-delta-F508 exhibits a correctable protein-folding defect. Protein Quality Control components identify and degrade proteins such as CFTR-delta-F508 that fail to acquire a native conformation. Loss of CFTR activity results in improper lung mucosa hydration and causes cystic fibrosis. Components that function in the CFTR biogenic pathway have been identified. However, to more fully understand the folding defect and to identify the biogenic intermediate that is selected for degradation it is necessary to identify the Quality Control components responsible for CFTR-delta-F508 degradation. Herein we identify two novel multi-subunit E3 Ubiquitin Ligase complexes: the cytosolic Hsc70/CHIP/UbcH5a complex, and the ER localized Derlin-1/RMA1/Ubc6e complex. Inactivation of the Hsc70/CHIP/UbcH5a complex using a mutant dominant negative form of UbcH5a has led to the identification of a CFTR-delta-F508 biogenic intermediate that can acquire a detergent soluble stable interaction with molecular chaperones and upon exposure to 26 degrees C, can fold and be expressed at the plasma membrane (PM). Studies utilizing both the Hsc70/CHIP/UbcH5a complex and the Derlin-1/RMA1/Ubc6e complex to comparatively study the sensitivity of CFTR biogenic intermediates to each quality control component has led to the finding that the kinetically trapped folding intermediate caused by the delta-F508 mutation is identified by the Derlin-1/RMA1/Ubc6e complex early in the biogenic process. Thus, these studies have been instrumental in the discovery of two sequential Quality Control checkpoints that function to target CFTR-delta-F508 for proteasomal degradation

Placenta Percreta; A Report On Surviving Death From The Bleeding Disaster!

A 34 year old G6P5 diagnosed with placenta previa percreta (fig 1) in her 2nd trimester was reviewed by a multidisciplinary team. Baby delivery was planned at 34 weeks gestation by cesarean hysterectomy(CH) immediately preceded by bilateral ureteral stents for anticipated surgical complexity. Patient received combined spinal and epidural (not activated) for the ureteric stenting with an aim to use the epidural for post-operative analgesia followed by general anesthesia and establishment of invasive lines and monitoring prior to start of CH. Soon after baby delivery, patient became hypotensive from severe hemorrhage. Massive transfusion protocol was instituted. After completion of hysterectomy, patient continued to bleed from multiple intraabdominal sites. While surgical hemostasis remained a challenge, patient developed PEA arrest. CPR was started with return of spontaneous circulation (ROSC) after chest compression for 2 minutes and 1mg of epinephrine. Following this, abdomen was packed with a decision to close secondarily after interventional radiology (IR) assisted intervention if necessary and hemodynamic stabilization. Intraoperatively, patient received a total of 29pRBCs, 22FFP, 4platelet & 3Cryo units with 21 L of crystalloids, 3.25 L of 5% albumin and 1.8L of cell saver with an estimated blood loss of 25L. Tranexamic acid and prothrombin complex concentrate was given. Thromboelastogram (TEG) and lab based coagulation profile was used intraoperatively to guide blood component transfusion. Serial blood gas analyses guided volume and electrolyte correction. In the ICU patient improved with no neurological insult or DIC. On postop day 1 IR found no active extravasations and surgical abdominal closure was performed. Epidural catheter was used for postoperative pain control and was removed on day 4. Patient was discharged on postop day 10.https://scholarlycommons.henryford.com/merf2020caserpt/1124/thumbnail.jp

Placenta Percreta: A Report On Surviving Death From The Bleeding Disaster!

https://scholarlycommons.henryford.com/merf2020caserpt/1001/thumbnail.jp

Hill of Banchory Geothermal Energy Project Feasibility Study Report

This feasibility study explored the potential for a deep geothermal heat project at Hill of Banchory, Aberdeenshire. The geology of the Hill of Fare, to the north of Banchory, gives cause to believe it has good geothermal potential, while the Hill of Banchory heat network, situated on the northern side of the town, offers a ready-made heat customer. The partners in the consortium consisted of academics and developers with relevant expertise in deep geothermal energy, heat networks, and financial analysis, together with representatives of local Government. They conducted geological fieldwork around the Hill of Fare, engaged with local residents to establish their attitudes to geothermal energy, and built business models to predict the conditions under which the heat network at Hill of Banchory would be commercial if it utilised heat from the proposed geothermal well. They also estimated the potential carbon emission reductions that could be achieved by using deep geothermal energy, both at Hill of Banchory and more widely

Renewing the Exploration Approach for Mid-Enthalpy Systems: Examples from Northern England and Scotland

After a promising start in the 1970s and 80s, the UK rather fell behind other countries in the search for viable mid-enthalpy geothermal resources. This situation began to turn around in 2004, when the first of three deep geothermal exploration boreholes were drilled in northern England. What distinguished these from earlier drilling in Cornwall was the deliberate search for naturallyhigh permeability associated with major faults, especially those that have undergone strike-slip reactivation during the Cenozoic. Boreholes at Eastgate in the North Pennines targeted buried radiothermal granite, whereas the 1,821m-deep Science Central Borehole in Newcastle upon Tyne targeted a postulated deep sedimentary aquifer (the Fell Sandstones), which were inferred to be connected laterally to the granitic heat source by a major fault (the reactivation of the Iapetus geo-suture). The drilling was in both cases rewarded with impressive heat flows, and in the case of Eastgate with what is believed to be the highest permeability yet found in a deep granite batholith anywhere in the world. In parallel with these developments, a re-assessment was made of the preexisting geothermal heat flow database for the UK, applying newly-standardised correction protocols for palaeoclimatic and topographic distortions, which were found to be particularly marked in Scotland (where only shallow boreholes had been used to establish geothermal gradients in the original 1980s analysis), Similar prospects in northern England (similar to that drilled at Science Central) are now the focus of commercial exploration efforts. Appraisal of fault dispositions relative to the present-day maximum compressive stress azimuth are being used to identify the most promising areas for intersecting fault-related permeability at depth. New geophysical tools – most notably atomic dielectric resonance scanning – are also being appraised for their ability to directly detect features (such as hot brines) which are indicative of localised convection in target fault zones and aquifers

Texas Crawfish Aquaculture.

34 p