Understanding the National Student Survey: investigations in languages, linguistics and area studies

This report is a summary of interviews and focus groups with around 100 students and 50 members of academic staff in departments of languages, linguistics or area studies at nine universities in the UK. In recent years, concerns have been expressed about the ambiguity of some of the statements which students are asked to respond to in the National Student Survey (NSS). This project set out to get a better understanding of how students and staff understand the questions. The interviews and focus groups were carried out by members of academic staff at the nine institutions who each then wrote an individual report of their findings. This summary is designed to enable wider distribution of these findings without identifying individual staff, institutions `or departments

The Future of Agent-Based Modeling

In this paper, I elaborate on the role of agent-based (AB) modeling for macroeconomic research. My main tenet is that the full potential of the AB approach has not been realized yet. This potential lies in the modular nature of the models, which is bought by abandoning the straitjacket of rational expectations and embracing an evolutionary perspective. I envisage the foundation of a Modular Macroeconomic Science, where new models with heterogeneous interacting agents, endowed with partial information and limited computational ability, can be created by recombining and extending existing models in a unified computational framework

The Natural History of Trachoma Infection and Disease in a Gambian Cohort with Frequent Follow-Up

Trachoma is an infectious disease of the eye that causes blindness in many of the poorest parts of the world. In this paper, we use a novel statistical approach to estimate the characteristics of this disease among people living in The Gambia who were examined every 2 weeks over a 6-month period. We found that the typical duration of infection with Chlamydia trachomatis and of clinically active disease were significantly longer than previously estimated. We tested different hypotheses about the natural history of trachoma that explain the relationship between infection and disease observed in the field. We also confirmed that disease lasts significantly longer among young children under 5 years old compared with older children and adults, even after accounting for high rates of re-infection in this age group, consistent with the development of immunity with age. The long duration of infection, especially among younger children, contributes to the persistence and gradual return of trachoma after community-wide treatment with azithromycin. This implies the need for high treatment coverage if infection is to be eliminated from a community, even where the return of infection after treatment is seen to be slow

Illuminating Medulloblastoma

Medulloblastoma, a childhood brain cancer of the cerebellum, has one of the highest mortality rates of pediatric cancers. For over a century, scientists believed that medulloblastoma metastasized exclusively through cerebrospinal fluid; however, novel research reveals that it can also spread through the circulatory system. Understanding this new mechanism is critical for the development of therapies and to help affected families understand their child’s disease. An educational 3D animation was developed to effectively disseminate this research to the scientific community and to educate physicians, researchers, and affected families about this disease. A story-driven narrative and emphasis on visual metaphor put the research in context by establishing why this research matters, what the future implications are, and how it is relevant to the audience. Additionally, various visual design strategies were implemented in order to increase memory retention and audience engagement. The final animation is the first visual resource that educates a lay audience on the two different mechanisms of medulloblastoma metastasis

Alpha1-microglobulin, beta2-microglobulin and retinol binding protein in childhood febrile illness and renal disease

Serum and urinary levels of alpha-1-microglobulin (A1M), beta-2-microglobulin (B2M) and retinol binding protein (RBP) were measured using a Mancini radial immunodiffusion technique in 52 children with renal disease, 36 with non-renal febrile illness and 29 controls. In controls the mean serum level for A1M was 25±4.6 (SD) mg/l for B2M 1.7±0.5 mg/l and for RBP 31±8 mg/l. A1M levels were not significantly altered by febrile illness while B2M was elevated and RBP markedly depressed. Serum A1M and B2M were elevated in the nephrotic syndrome, while serum B2M was also raised during infancy. Coefficients of log-transformed data with creatinine-derived glomerular filtration rate (GFR) were −0.87 for B2M, −0.71 for RBP, and −0.62 for A1M. In the urine A1M was always measurable in controls while B2M and RBP were undetectable in all but a small number. The urine levels of all three proteins increased in response to non-renal febrile illness, and rose invariably when GFR fell to below 40–50 ml/min per 1.73 m2. Of the three proteins A1M was most frequently elevated in the urine with febrile and renal illness. RBP was rarely detectable when the other two proteins were not. Urinary A1M was consistently elevated in the nephrotic syndrome in contrast to B2M, possibly as a reflection of the increased glomerular permeability. We conclude that serum B2M is superior to A1M and RBP as an index of glomerular filtration, although its levels should be interpreted with caution in febrile disease. With the Mancini assay both urinary A1M and B2M measurement are of value, especially when taken in combination, but further work is required to determine the specificity of A1M for tubular as opposed to glomerular dysfunction, especially in the nephrotic state

Life cycle assessment for reuse/recycling of donated waste textiles compared to use of virgin material: an UK energy saving perspective

In the UK, between 4 and 5% of the municipal solid waste stream is composed of clothes/textiles. Approximately 25% of this is recycled by companies such as the Salvation Army Trading Company Limited (SATCOL) who provide a collection and distribution infrastructure for ‘donated’ clothing and shoes. Textiles can be reused or undergo a processing stage and enter a recycling stream. Research was conducted in order to quantify the energy used by a reuse/recycling operation and whether this resulted in a net energy benefit. The energy footprint was quantified using a streamlined life cycle assessment (LCA), an LCA restricted in scope in order to target specific aspects of the footprint, in this case energy consumption. Taking into account extraction of resources, manufacture of materials, electricity generation, clothing collection, processing and distribution and final disposal of wastes it was demonstrated that for every kilogram of virgin cotton displaced by second hand clothing approximately 65 kWh is saved, and for every kilogram of polyester around 90 kWh is saved. Therefore, the reuse and recycling of the donated clothing results in a reduction in the environmental burden compared to purchasing new clothing made from virgin materials

The orbitozygomatic approach

OBJECTIVE: The orbitozygomatic approach is a modification and extension of the pterional craniotomy to gain a wider exposure of structures at a cranial base. To simplify the understanding and performance of the approach, we developed a teaching video that follows a systematic approach to the surgical anatomy and technique. METHODS: The authors have incorporated three-dimensional (3D) renderings into the descriptions of the surgical technique and contemporary computer animation is used to demonstrate surgical details and nuances of the procedure. RESULTS: A teaching video was compiled, and it was well received by neurosurgical residents in Europe and Canada. CONCLUSION: With mastery in the surgical laboratory and with guided supervision, the approach can be routinely applied without adding morbidity to a variety of pathologies such as aneurysms and tumor