Power Side Channels in Security ICs: Hardware Countermeasures

Power side-channel attacks are a very effective cryptanalysis technique that can infer secret keys of security ICs by monitoring the power consumption. Since the emergence of practical attacks in the late 90s, they have been a major threat to many cryptographic-equipped devices including smart cards, encrypted FPGA designs, and mobile phones. Designers and manufacturers of cryptographic devices have in response developed various countermeasures for protection. Attacking methods have also evolved to counteract resistant implementations. This paper reviews foundational power analysis attack techniques and examines a variety of hardware design mitigations. The aim is to highlight exposed vulnerabilities in hardware-based countermeasures for future more secure implementations

Evidence for inbreeding depression in a species with limited opportunity for maternal effects

It is often assumed that mating with close relatives reduces offspring fitness. In such cases, reduced offspring fitness may arise from inbreeding depression (i.e., genetic effects of elevated homozygosity) or from post-mating maternal investment. This can be due to a reduction in female investment after mating with genetically incompatible males ("differential allocation") or compensation for incompatibility ("reproductive compensation"). Here, we looked at the effects of mating with relatives on offspring fitness in mosquitofish, Gambusia holbrooki. In this species, females are assumed to be nonplacental and to allocate resources to eggs before fertilization, limiting differential allocation. We looked at the effects of mating with a brother or with an unrelated male on brood size, offspring size, gestation period, and early offspring growth. Mating with a relative reduced the number of offspring at birth, but there was no difference in the likelihood of breeding, gestation time, nor in the size or growth of these offspring. We suggest that due to limited potential for maternal effects to influence these traits that any reduction in offspring fitness, or lack thereof, can be explained by inbreeding depression rather than by maternal effects. We highlight the importance of considering the potential role of maternal effects when studying inbreeding depression and encourage further studies in other Poeciliid species with different degrees of placentation to test whether maternal effects mask or amplify any genetic effects of mating with relatives.This work was supported bythe Australian Research Council (DP120100339). R.V.-T. is supported by fellowships from Consejo Nacion-al de Ciencia y Tecnologıa-Mexico and the ResearchSchool of Biology

Hombres y Hermandad (Men & Brotherhood): Exploring the Role of Fraternity Involvement on Latino Masculinity Development in College

Despite accounting for the largest increase in higher education enrollment over the last ten years, Latinx students have continued to earn their bachelor’s degrees among the lowest rates of all racial/ethnic groups. Latino men specifically have continued to underperform Latina females, maintaining one of the widest gender gaps in bachelor’s degree completion rates. There are various challenges that all Latinx students face in relation to earning their bachelor’s degree within six years, however there are unique gender norms within the Latinx culture that impact Latino male students in a more significant way. Tenets of their Latino masculinity create expectations where Latino men are more inclined to seek out opportunities to stay close to family and provide financially rather than dedicating themselves to their college education. There are, however, other aspects of masculinity which help Latino men perceive their higher education as a way to make their families proud and be more able to fulfill their male roles within the Latinx culture. Harris’s Meanings of Masculinity model notes that there are various factors that influence how masculinity develops in college; one significant influencing factor being fraternity involvement. Using Harris’s model as a framework, this study explores the experiences of Latino men involved in fraternities and how they feel their involvement as impacted the development of their ideas of Latino masculinity. The study specifically made note of experiences within their fraternity that may have influenced the development of masculinity ideas that are more aligned with college success

Hombres y Hermandad (Men & Brotherhood): Exploring the Role of Fraternity Involvement on Latino Masculinity Development in College

Despite accounting for the largest increase in higher education enrollment over the last ten years, Latinx students have continued to earn their bachelor’s degrees among the lowest rates of all racial/ethnic groups. Latino men specifically have continued to underperform Latina females, maintaining one of the widest gender gaps in bachelor’s degree completion rates. There are various challenges that all Latinx students face in relation to earning their bachelor’s degree within six years, however there are unique gender norms within the Latinx culture that impact Latino male students in a more significant way. Tenets of their Latino masculinity create expectations where Latino men are more inclined to seek out opportunities to stay close to family and provide financially rather than dedicating themselves to their college education. There are, however, other aspects of masculinity which help Latino men perceive their higher education as a way to make their families proud and be more able to fulfill their male roles within the Latinx culture. Harris’s Meanings of Masculinity model notes that there are various factors that influence how masculinity develops in college; one significant influencing factor being fraternity involvement. Using Harris’s model as a framework, this study explores the experiences of Latino men involved in fraternities and how they feel their involvement as impacted the development of their ideas of Latino masculinity. The study specifically made note of experiences within their fraternity that may have influenced the development of masculinity ideas that are more aligned with college success

Development of a targeted and controlled nanoparticle delivery system for FoxO1 inhibitors

Background: Poly (lactic-co-glycolic acid) (PLGA) and polyethylene glycol (PEG) are polymers approved by the United States’ Food and Drug Administration. Drugs for various medical treatments have been encapsulated in PLGA-PEG nanoparticles for targeted delivery and reduction of unwanted side effects. Methods: A flow synthesis method for PLGA-PEG nanoparticles containing FoxO1 inhibitors and adipose vasculature targeting agents was developed. A set of nanoparticles including PLGA and PLGA-PEG-P3 unloaded and drug loaded were generated. The particles were characterized by DLS, fluorescence spectroscopy, TEM, and dialysis. Endotoxin levels were measured using the LAL chromogenic assay. Our approach was compared to over 270 research articles using information extraction tools. Results: Nanoparticle hydrodynamic diameters ranged from 142.4 ±0.4 d.nm to 208.7 ±3.6 d.nm while the polydispersity index was less than 0.500 for all samples (0.057 ±0.021 to 0.369 ±0.038). Zeta potentials were all negative ranging from -4.33 mV to -13.4 mV. Stability testing confirmed that size remained unchanged for up to 4 weeks. For AS1842856, loading was 0.5 mg drug/mL solution and encapsulation efficiency was ~100%. Dialysis indicated burst release of drug in the first 4 hours. Conclusion: PLGA encapsulation of AS1842856 was successful but unsuccessful for the two more hydrophilic drugs. Alternative syntheses such as water/oil/water emulsion or liposomal encapsulation are being considered. Analysis of data from published papers on PLGA nanoparticles indicated that our results were consistent with identified process-structure relationships and few groups reported endotoxin levels even though in vivo testing was performed.https://scholarscompass.vcu.edu/gradposters/1071/thumbnail.jp

Prethermalization and Persistent Order in the Absence of a Thermal Phase Transition

We numerically study the dynamics after a parameter quench in the one-dimensional transverse-field Ising model with long-range interactions ($\propto 1/r^\alpha$ with distance $r$), for finite chains and also directly in the thermodynamic limit. In nonequilibrium, i.e., before the system settles into a thermal state, we find a long-lived regime that is characterized by a prethermal value of the magnetization, which in general differs from its thermal value. We find that the ferromagnetic phase is stabilized dynamically: as a function of the quench parameter, the prethermal magnetization shows a transition between a symmetry-broken and a symmetric phase, even for those values of $\alpha$ for which no finite-temperature transition occurs in equilibrium. The dynamical critical point is shifted with respect to the equilibrium one, and the shift is found to depend on $\alpha$ as well as on the quench parameters.Comment: 6 pages, 4 figure

Coronary Disease in Emergency Department Chest Pain Patients with Recent Negative Stress Testing

Background: Cardiac stress tests for diagnosis of coronary artery disease (CAD) are incompletely sensitive and specific.Objective: We examined the frequency of significant CAD in patients presenting to the emergency department (ED) with chest pain who have had a recent negative or inconclusive (<85% of predicted maximum heart rate) cardiac stress test.Methods: This was a retrospective chart review of patients identified from ED and cardiology registries at the study hospital. We included patients presenting to the ED with a chief complaint of chest pain, with a negative cardiac stress test in the past three years as the last cardiac test, and hospital admission. One-hundred sixty-four patients met the inclusion criteria. Their admission was reviewed for diagnosis of CAD by positive serum troponin, percutaneous coronary intervention, or positive stress test while an inpatient.Results: Of 164 patients, 122 (74.4%, 95% CI 67.7, 81.1) had a negative stress test prior to the index admission, while 42 (25.6%, 95% CI 18.9, 32.3) had otherwise normal but inconclusive stress tests. Thirty-four (20.7%, 95% CI 14.4,27.0) of the included patients were determined to have CAD. Twenty-five of the 122 patients (20.5%, 95% CI 13.3, 27.7) had negative pre-admission stress tests and nine of 42 patients (21.4%, 95% CI 9.0, 33.8) had inclusive stress tests of CAD. A statistical comparison between these two proportions showed no significant difference (p = .973).Conclusion: Due to inadequate sensitivity, negative non-invasive cardiac stress tests should not be used to rule out CAD. Patients with negative stress tests are just as likely to have CAD as patients with inconclusive stress tests. [West J Emerg Med 2010; 11(4):384-388.

Are sexually selected traits affected by a poor environment early in life?

Background: Challenging conditions experienced early in life, such as a restricted diet, can detrimentally affect key life-history traits. Individuals can reduce these costs by delaying their sexual maturation, albeit at the price of the later onset of breeding, to eventually reach the same adult size as individuals that grow up in a benevolent environment. Delayed maturation can, however, still lead to other detrimental morphological and physiological changes that become apparent later in adulthood (e.g. shorter lifespan, faster senescence). In general, research focuses on the naturally selected costs of a poor early diet. In mosquitofish (Gambusia holbrooki), males with limited food intake early in life delay maturation to reach a similar adult body size to their well-fed counterparts (‘catch-up growth’). Here we tested whether a poor early diet is costly due to the reduced expression of sexually selected male characters, namely genital size and ejaculate traits. Results: We found that a male’s diet early in life significantly influenced his sperm reserves and sperm replenishment rate. Shortly after maturation males with a restricted early diet had significantly lower sperm reserves and slower replenishment rates than control diet males, but this dietary difference was no longer detectable in older males. Conclusions: Although delaying maturation to reach the same body size as well fed juveniles can ameliorate some costs of a poor start in life, our findings suggest that costs might still arise because of sexual selection against these males. It should be noted, however, that the observed effects are modest (Hedges’ g = 0.20-0.36), and the assumption that lower sperm production translates into a decline in fitness under sperm competition remains unconfirmed

Effective Floquet Hamiltonians for periodically-driven twisted bilayer graphene

We derive effective Floquet Hamiltonians for twisted bilayer graphene driven by circularly polarized light in two different regimes beyond the weak-drive, high frequency regime. First, we consider a driving protocol relevant for experiments with frequencies smaller than the bandwidth and weak amplitudes and derive an effective Hamiltonian, which through a symmetry analysis, provides analytical insight into the rich effects of the drive. We find that circularly polarized light at low frequencies can selectively decrease the strength of AA-type interlayer hopping while leaving the AB-type unaffected. Then, we consider the intermediate frequency, and intermediate-strength drive regime. We provide a compact and accurate effective Hamiltonian which we compare with the Van Vleck expansion and demonstrate that it provides a significantly improved representation of the exact quasienergies. Finally, we discuss the effect of the drive on the symmetries, Fermi velocity and the gap of the Floquet flat bands