One Under Glass

Grand Central Station 5:10 I blend myself into the train which sits in the slip waiting to fill with faceless angels and threats colored post 50\u27s win well-aged wafts into the seat beside me..

Uncovering Marginalized Topics Using WebQuests: From Atlanta to the Zoot Suit Riots

A critical part of social studies instruction is involving students in making sense of social issues in the past and present to help inform their decisions in the future. Through engaged inquiry students can tackle relevant topics associated with race, class, culture, gender, language, and nationality and explore how these challenging issues mitigate people’s experiences. Moreover, these issues reflect similar tensions that students encounter in their everyday lives. Although these social issues have historical and contemporary relevance, they often are marginalized in state standards and textbooks

Uncovering Marginalized Topics Using WebQuests: From Atlanta to the Zoot Suit Riots

A critical part of social studies instruction is involving students in making sense of social issues in the past and present to help inform their decisions in the future. Through engaged inquiry students can tackle relevant topics associated with race, class, culture, gender, language, and nationality and explore how these challenging issues mitigate people’s experiences. Moreover, these issues reflect similar tensions that students encounter in their everyday lives. Although these social issues have historical and contemporary relevance, they often are marginalized in state standards and textbooks

Optimal Sequential Selection of a Monotone Sequence From a Random Sample

The length of the longest monotone increasing subsequence of a random sample of size n is known to have expected value asymptotic to 2n1/2. We prove that it is possible to make sequential choices which give an increasing subsequence of expected length asymptotic to (2n)1/2. Moreover, this rate of increase is proved to be asymptotically best possible

State of Health in Northern Kentucky: How We Compare, Why it Matters to Business

County-level data is becoming increasingly important for rural health planning. This presentation analyzes the health of several northern Kentucky counties and the potential consequences for the region’s employers

Assessment of Physician Workforce Supply and Demand in the US

Rural community and migrant health centers face major problems in attracting and retaining physicians. This presentation addresses that issue by projecting health services demands, physician specialty distribution and physician supply, as well as suggesting methods for increasing physician supply and reducing consumer demand

Stability of a fluid in a rectangular region heated from below

Finite-difference methods were used to compute hydrodynamic instability due to natural convection in an enclosed horizontal rectangular region heated from below. Critical Rayleigh numbers were determined for a series of Prandtl numbers and length-to-height ratios. For Prandtl numbers greater than unity excellent agreement was obtained between these calculations and the values predicted by Kurzweg on the basis of a linearized theory. However, for Prandtl numbers less than unity the critical Rayleigh numbers exhibited a dependence on N Pr , which was not predicted by the linearized theory. For Rayleigh numbers greater than the critical, complete temperature and velocity fields were determined. The calculations assumed that the fluid motion is two dimensional. Experiments have indicated that the flow may be two or three dimensional depending on minor perturbations in the boundary conditions. Although a number of metastable two-dimensional circulations are possible for symmetrical initial conditions, the calculation always converged to a single, unique solution for any asymmetric initial condition.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/37346/1/690130115_ftp.pd

Chronic Social Defeat Alters Brain Vascular-Associated Cell Gene Expression Patterns Leading to Vascular Dysfunction and Immune System Activation

Brain vascular integrity is critical for brain health, and its disruption is implicated in many brain pathologies, including psychiatric disorders. Brain-vascular barriers are a complex cellular landscape composed of endothelial, glial, mural, and immune cells. Yet currently, little is known about these brain vascular-associated cells (BVACs) in health and disease. Previously, we demonstrated that 14 days of chronic social defeat (CSD), a mouse paradigm that produces anxiety and depressive-like behaviors, causes cerebrovascular damage in the form of scattered microbleeds. Here, we developed a technique to isolate barrier-related cells from the mouse brain and subjected the isolated cells to single-cell RNA sequencing. Using this isolation technique, we found an enrichment in BVAC populations, including distinct subsets of endothelial and microglial cells. In CSD compared to non-stress, home-cage control, differential gene expression patterns disclosed biological pathways involving vascular dysfunction, vascular healing, and immune system activation. Overall, our work demonstrates a unique technique to study BVAC populations from fresh brain tissue and suggests that neurovascular dysfunction is a key driver of psychosocial stress-induced brain pathology