2,695 research outputs found
A Conceptual Framework for Studying the Sources of Variation in Program Effects
Evaluations of public programs in many fields reveal that (1) different types of programs (or different versions of the same program) vary in their effectiveness, (2) a program that is effective for one group of people might not be effective for other groups of people, and (3) a program that is effective in one set of circumstances may not be effective in other circumstances. This paper presents a conceptual framework for research on such variation in program effects and the sources of this variation. The framework is intended to help researchers -- both those who focus mainly on studying program implementation and those who focus mainly on estimating program effects -- see how their respective pieces fit together in a way that helps to identify factors that explain variation in program effects and thereby support more systematic data collection on these factors. The ultimate goal of the framework is to enable researchers to offer better guidance to policymakers and program operators on the conditions and practices that are associated with larger and more positive effects
Maternal Serum Polychlorinated Biphenyl Concentrations across Critical Windows of Human Development
Background Few data are available on polychlorinated biphenyl (PCB) concentrations over critical windows of human reproduction and development inclusive of the periconception window. Objectives Our goal was to measure changes in PCB concentrations from preconception to pregnancy, through pregnancy, or after a year without becoming pregnant. Methods Seventy-nine women planning pregnancies were prospectively enrolled and followed for up to 12 menstrual cycles of attempting pregnancy. Blood specimens were obtained from participating women preconceptionally (n = 79), after a positive pregnancy test leading to a live birth (n = 54) or pregnancy loss (n= 10), at approximately 6 weeks postpartum (n = 53), and after 12 unsuccessful cycles (n = 9) for toxicologic analysis of 76 PCB congeners. We estimated overall and daily rate of change in PCB concentration (nanograms per gram serum) adjusting for relevant covariates, serum lipids, and baseline PCB concentration. Results Significant (p \u3c 0.0001) decreases in the mean overall and daily rate of change in PCB concentrations were observed between the preconception and first pregnancy samples for total (â1.012 and â0.034, respectively), estrogenic (â0.444 and â0.016, respectively), and antiestrogenic (â0.106 and â0.004, respectively) PCBs among women with live births. Similar significant decreases in total (â1.452 and â0.085), estrogenic (â0.647 and â0.040), and antiestrogenic (â0.093 and â0.004) PCB concentrations were seen for women with pregnancy losses. No significant changes were observed for PCB congener 153. Conclusions These data suggest that PCB concentrations may change during the periconception interval, questioning the stability of persistent compounds during this critical window
The SAMI Galaxy Survey: Shocks and Outflows in a normal star-forming galaxy
We demonstrate the feasibility and potential of using large integral field
spectroscopic surveys to investigate the prevalence of galactic-scale outflows
in the local Universe. Using integral field data from SAMI and the Wide Field
Spectrograph, we study the nature of an isolated disk galaxy, SDSS
J090005.05+000446.7 (z = 0.05386). In the integral field datasets, the galaxy
presents skewed line profiles changing with position in the galaxy. The skewed
line profiles are caused by different kinematic components overlapping in the
line-of-sight direction. We perform spectral decomposition to separate the line
profiles in each spatial pixel as combinations of (1) a narrow kinematic
component consistent with HII regions, (2) a broad kinematic component
consistent with shock excitation, and (3) an intermediate component consistent
with shock excitation and photoionisation mixing. The three kinematic
components have distinctly different velocity fields, velocity dispersions,
line ratios, and electron densities. We model the line ratios, velocity
dispersions, and electron densities with our MAPPINGS IV shock and
photoionisation models, and we reach remarkable agreement between the data and
the models. The models demonstrate that the different emission line properties
are caused by major galactic outflows that introduce shock excitation in
addition to photoionisation by star-forming activities. Interstellar shocks
embedded in the outflows shock-excite and compress the gas, causing the
elevated line ratios, velocity dispersions, and electron densities observed in
the broad kinematic component. We argue from energy considerations that, with
the lack of a powerful active galactic nucleus, the outflows are likely to be
driven by starburst activities. Our results set a benchmark of the type of
analysis that can be achieved by the SAMI Galaxy Survey on large numbers of
galaxies.Comment: 17 pages, 15 figures. Accepted to MNRAS. References update
Consumption of low-moderate level arsenic contaminated water does not increase spontaneous pregnancy loss: a case control study
Previous work suggests an increased risk for spontaneous pregnancy loss linked to high levels of inorganic arsenic (iAs) in drinking water sources (\u3e10 ÎŒg/L). However, there has been little focus to date on the impact of low-moderate levels of iAs in drinking water (\u3c10 \u3eÎŒg/L). To address this data gap we conducted a hospital-based caseâcontrol study in Timis County, Romania
X-ray phase contrast imaging of biological specimens with tabletop synchrotron radiation
Since their discovery in 1896, x-rays have had a profound impact on science, medicine and technology. Here we show that the x-rays from a novel tabletop source of bright coherent synchrotron radiation can be applied to phase contrast imaging of biological specimens, yielding superior image quality and avoiding the need for scarce or expensive conventional sources
A Study of the Diverse T Dwarf Population Revealed by WISE
We report the discovery of 87 new T dwarfs uncovered with the Wide-field
Infrared Survey Explorer (WISE) and three brown dwarfs with extremely red
near-infrared colors that exhibit characteristics of both L and T dwarfs. Two
of the new T dwarfs are likely binaries with L7+/-1 primaries and mid-type T
secondaries. In addition, our follow-up program has confirmed 10 previously
identified T dwarfs and four photometrically-selected L and T dwarf candidates
in the literature. This sample, along with the previous WISE discoveries,
triples the number of known brown dwarfs with spectral types later than T5.
Using the WISE All-Sky Source Catalog we present updated color-color and
color-type diagrams for all the WISE-discovered T and Y dwarfs. Near-infrared
spectra of the new discoveries are presented, along with spectral
classifications. To accommodate later T dwarfs we have modified the integrated
flux method of determining spectral indices to instead use the median flux.
Furthermore, a newly defined J-narrow index differentiates the early-type Y
dwarfs from late-type T dwarfs based on the J-band continuum slope. The K/J
indices for this expanded sample show that 32% of late-type T dwarfs have
suppressed K-band flux and are blue relative to the spectral standards, while
only 11% are redder than the standards. Comparison of the Y/J and K/J index to
models suggests diverse atmospheric conditions and supports the possible
re-emergence of clouds after the L/T transition. We also discuss peculiar brown
dwarfs and candidates that were found not to be substellar, including two Young
Stellar Objects and two Active Galactic Nuclei. The coolest WISE-discovered
brown dwarfs are the closest of their type and will remain the only sample of
their kind for many years to come.Comment: Accepted to ApJS on 15 January 2013; 99 pages in preprint format, 30
figures, 12 table
CfAIR2: Near Infrared Light Curves of 94 Type Ia Supernovae
CfAIR2 is a large homogeneously reduced set of near-infrared (NIR) light
curves for Type Ia supernovae (SN Ia) obtained with the 1.3m Peters Automated
InfraRed Imaging TELescope (PAIRITEL). This data set includes 4607 measurements
of 94 SN Ia and 4 additional SN Iax observed from 2005-2011 at the Fred
Lawrence Whipple Observatory on Mount Hopkins, Arizona. CfAIR2 includes JHKs
photometric measurements for 88 normal and 6 spectroscopically peculiar SN Ia
in the nearby universe, with a median redshift of z~0.021 for the normal SN Ia.
CfAIR2 data span the range from -13 days to +127 days from B-band maximum. More
than half of the light curves begin before the time of maximum and the coverage
typically contains ~13-18 epochs of observation, depending on the filter. We
present extensive tests that verify the fidelity of the CfAIR2 data pipeline,
including comparison to the excellent data of the Carnegie Supernova Project.
CfAIR2 contributes to a firm local anchor for supernova cosmology studies in
the NIR. Because SN Ia are more nearly standard candles in the NIR and are less
vulnerable to the vexing problems of extinction by dust, CfAIR2 will help the
supernova cosmology community develop more precise and accurate extragalactic
distance probes to improve our knowledge of cosmological parameters, including
dark energy and its potential time variation.Comment: 31 pages, 15 figures, 10 tables. Accepted to ApJS. v2 modified to
more closely match journal versio
Death receptor 3 (TNFRSF25) increases mineral apposition by osteoblasts and region specific new bone formation in the axial skeleton of male DBA/1 mice
Fraser L. Collins and this work were funded by an Arthritis Research UK PhD studentship (Grant Code: 18598) awarded to Anwen S. Williams, Eddie C. Y. Wang, and Michael D. Stone. Eddie C. Y. Wang was additionally funded by MRC Project Grant G0901119. Funding for open access was kindly provided by Cardiff University.Peer reviewedPublisher PD
Reverse Shock Emission Revealed in Early Photometry in the Candidate Short GRB 180418A
We present observations of the possible short GRB 180418A in -rays,
X-rays, and in the optical. Early optical photometry with the TAROT and RATIR
instruments show a bright peak ( 14.2 AB mag) between and
seconds that we interpret as the signature of a reversal shock. Later
observations can be modeled by a standard forward shock model and show no
evidence of jet break, allowing us to constrain the jet collimation to
. Using deep late-time optical observations we place an
upper limit of AB mag on any underlying host galaxy. The detection of
the afterglow in the \textit{Swift} UV filters constrains the GRB redshift to
and places an upper bound on the -ray isotropic equivalent
energy erg.
The properties of this GRB (e.g. duration, hardness ratio, energetic, and
environment) lie at the intersection between short and long bursts, and we can
not conclusively identify its type. We estimate that the probability that it is
drawn from the population of short GRBs is 10\%-30\%.Comment: Accepted por publication in Ap
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