304 research outputs found
Relative Astrometry of Compact Flaring Structures in Sgr A* with Polarimetric VLBI
We demonstrate that polarimetric interferometry can be used to extract
precise spatial information about compact polarized flares of Sgr A*. We show
that, for a faint dynamical component, a single interferometric baseline
suffices to determine both its polarization and projected displacement from the
quiescent intensity centroid. A second baseline enables two-dimensional
reconstruction of the displacement, and additional baselines can self-calibrate
using the flare, enhancing synthesis imaging of the quiescent emission. We
apply this technique to simulated 1.3-mm wavelength observations of a "hot
spot" embedded in a radiatively inefficient accretion disk around Sgr A*. Our
results indicate that, even with current sensitivities, polarimetric
interferometry with the Event Horizon Telescope can achieve ~5 microarcsecond
relative astrometry of compact flaring structures near Sgr A* on timescales of
minutes.Comment: 9 Pages, 4 Figures, accepted for publication in Ap
Dissociable electrophysiological measures of natural language processing reveal differences in speech comprehension strategy in healthy ageing
Healthy ageing leads to changes in the brain that impact upon sensory and cognitive processing. It is not fully clear how these changes affect the processing of everyday spoken language. Prediction is thought to play an important role in language comprehension, where information about upcoming words is pre-activated across multiple representational levels. However, evidence from electrophysiology suggests differences in how older and younger adults use context-based predictions, particularly at the level of semantic representation. We investigate these differences during natural speech comprehension by presenting older and younger subjects with continuous, narrative speech while recording their electroencephalogram. We use time-lagged linear regression to test how distinct computational measures of (1) semantic dissimilarity and (2) lexical surprisal are processed in the brains of both groups. Our results reveal dissociable neural correlates of these two measures that suggest differences in how younger and older adults successfully comprehend speech. Specifically, our results suggest that, while younger and older subjects both employ context-based lexical predictions, older subjects are significantly less likely to pre-activate the semantic features relating to upcoming words. Furthermore, across our group of older adults, we show that the weaker the neural signature of this semantic pre-activation mechanism, the lower a subject's semantic verbal fluency score. We interpret these findings as prediction playing a generally reduced role at a semantic level in the brains of older listeners during speech comprehension and that these changes may be part of an overall strategy to successfully comprehend speech with reduced cognitive resources
Morphological and hemodynamical alterations in brachial artery and cephalic vein. An image‐based study for preoperative assessment for vascular access creation
The current study aims to computationally evaluate the effect of right upper arm position on the geometric and hemodynamic characteristics of the brachial artery (BA) and cephalic vein (CV) and, furthermore, to present in detail the methodology to characterise morphological and hemodynamical healthy vessels. Ten healthy volunteers were analysed in two configurations, the supine (S) and the prone (P) position. Lumen 3D surface models were constructed from images acquired from a non-contrast MRI sequence. Then, the models were used to numerically compute the physiological range of geometric (n = 10) and hemodynamic (n = 3) parameters in the BA and CV. Geometric parameters such as curvature and tortuosity, and hemodynamic parameters based on wall shear stress (WSS) metrics were calculated with the use of computational fluid dynamics. Our results highlight that changes in arm position had a greater impact on WSS metrics of the BA by altering the mean and maximum blood flow rate of the vessel. Whereas, curvature and tortuosity were found not to be significantly different between positions. Inter-variability was associated with antegrade and retrograde flow in BA, and antegrade flow in CV. Shear stress was low and oscillatory shear forces were negligible. This data suggests that deviations from this state may contribute to the risk of accelerated intimal hyperplasia of the vein in arteriovenous fistulas. Therefore, preoperative conditions coupled with post-operative longitudinal data will aid the identification of such relationships
Electronic structure evolution in dilute carbide Ge1-xCx alloys and implications for device applications
We present a theoretical analysis of electronic structure evolution in the highly-mismatched dilute carbide group-IV alloy Ge1−xCx. For ordered alloy supercells, we demonstrate that C incorporation strongly perturbs the conduction band (CB) structure by driving the hybridization of A1-symmetric linear combinations of Ge states lying close in energy to the CB edge. This leads, in the ultradilute limit, to the alloy CB edge being formed primarily of an A1-symmetric linear combination of the L-point CB edge states of the Ge host matrix semiconductor. Our calculations describe the emergence of a “quasidirect” alloy bandgap, which retains a significant admixture of indirect Ge L-point CB edge character. We then analyze the evolution of the electronic structure of realistic (large, disordered) Ge1−xCx alloy supercells for C compositions up to x=2%. We show that short-range alloy disorder introduces a distribution of localized states at energies below the Ge CB edge, with these states acquiring minimal direct (Γ) character. Our calculations demonstrate strong intrinsic inhomogeneous energy broadening of the CB edge Bloch character, driven by hybridization between Ge host matrix and C-related localized states. The trends identified by our calculations are markedly different to those expected based on a recently proposed interpretation of the CB structure based on the band anticrossing model. The implications of our findings for device applications are discussed
Detection of intrinsic source structure at ~3 Schwarzschild radii with Millimeter-VLBI observations of SAGITTARIUS A*
We report results from very long baseline interferometric (VLBI) observations
of the supermassive black hole in the Galactic center, Sgr A*, at 1.3 mm (230
GHz). The observations were performed in 2013 March using six VLBI stations in
Hawaii, California, Arizona, and Chile. Compared to earlier observations, the
addition of the APEX telescope in Chile almost doubles the longest baseline
length in the array, provides additional {\it uv} coverage in the N-S
direction, and leads to a spatial resolution of 30 as (3
Schwarzschild radii) for Sgr A*. The source is detected even at the longest
baselines with visibility amplitudes of 4-13% of the total flux density.
We argue that such flux densities cannot result from interstellar refractive
scattering alone, but indicate the presence of compact intrinsic source
structure on scales of 3 Schwarzschild radii. The measured nonzero
closure phases rule out point-symmetric emission. We discuss our results in the
context of simple geometric models that capture the basic characteristics and
brightness distributions of disk- and jet-dominated models and show that both
can reproduce the observed data. Common to these models are the brightness
asymmetry, the orientation, and characteristic sizes, which are comparable to
the expected size of the black hole shadow. Future 1.3 mm VLBI observations
with an expanded array and better sensitivity will allow a more detailed
imaging of the horizon-scale structure and bear the potential for a deep
insight into the physical processes at the black hole boundary.Comment: 11 pages, 5 figures, accepted to Ap
Identifying transient and variable sources in radio images
With the arrival of a number of wide-field snapshot image-plane radio transient surveys, there will be a huge influx of images in the coming years making it impossible to manually analyse the datasets. Automated pipelines to process the information stored in the images are being developed, such as the LOFAR Transients Pipeline, outputting light curves and various transient parameters. These pipelines have a number of tuneable parameters that require training to meet the survey requirements. This paper utilises both observed and simulated datasets to demonstrate different machine learning strategies that can be used to train these parameters. We use a simple anomaly detection algorithm and a penalised logistic regression algorithm. The datasets used are from LOFAR observations and we process the data using the LOFAR Transients Pipeline; however the strategies developed are applicable to any light curve datasets at different frequencies and can be adapted to different automated pipelines. These machine learning strategies are publicly available as PYTHON tools that can be downloaded and adapted to different datasets (https://github.com/AntoniaR/TraP_ML_tools)
Acquisition of Apoptotic Resistance in Cadmium-Transformed Human Prostate Epithelial Cells: Bcl-2 Overexpression Blocks the Activation of JNK Signal Transduction Pathway
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