799 research outputs found
Detections and Constraints on White Dwarf Variability from Time-Series GALEX Observations
We search for photometric variability in more than 23,000 known and candidate
white dwarfs, the largest ultraviolet survey compiled for a single study of
white dwarfs. We use gPhoton, a publicly available calibration/reduction
pipeline, to generate time-series photometry of white dwarfs observed by GALEX.
By implementing a system of weighted metrics, we select sources with
variability due to pulsations and eclipses. Although GALEX observations have
short baselines (< 30 min), we identify intrinsic variability in sources as
faint as Gaia G = 20 mag. With our ranking algorithm, we identify 49 new
variable white dwarfs (WDs) in archival GALEX observations. We detect 41 new
pulsators: 37 have hydrogen-dominated atmospheres (DAVs), including one
possible massive DAV, and four are helium-dominated pulsators (DBVs). We also
detect eight new eclipsing systems; five are new discoveries, and three were
previously known spectroscopic binaries. We perform synthetic injections of the
light curve of WD 1145+017, a system with known transiting debris, to test our
ability to recover similar systems. We find that the 3{\sigma} maximum
occurrence rate of WD 1145+017-like transiting objects is < 0.5%.Comment: 17 pages, 13 figure
The star-formation history of the universe - an infrared perspective
A simple and versatile parameterized approach to the star formation history
allows a quantitative investigation of the constraints from far infrared and
submillimetre counts and background intensity measurements.
The models include four spectral components: infrared cirrus (emission from
interstellar dust), an M82-like starburst, an Arp220-like starburst and an AGN
dust torus. The 60 m luminosity function is determined for each chosen
rate of evolution using the PSCz redshift data for 15000 galaxies. The
proportions of each spectral type as a function of 60 m luminosity are
chosen for consistency with IRAS and SCUBA colour-luminosity relations, and
with the fraction of AGN as a function of luminosity found in 12 m
samples. The luminosity function for each component at any wavelength can then
be calculated from the assumed spectral energy distributions. With assumptions
about the optical seds corresponding to each component and, for the AGN
component, the optical and near infrared counts can be accurately modelled.
A good fit to the observed counts at 0.44, 2.2, 15, 60, 90, 175 and 850
m can be found with pure luminosity evolution in all 3 cosmological models
investigated: = 1, = 0.3 ( = 0), and
= 0.3, = 0.7.
All 3 models also give an acceptable fit to the integrated background
spectrum. Selected predictions of the models, for example redshift
distributions for each component at selected wavelengths and fluxes, are shown.
The total mass-density of stars generated is consistent with that observed,
in all 3 cosmological models.Comment: 20 pages, 25 figures. Accepted for publication in ApJ. Full details
of models can be found at http://astro.ic.ac.uk/~mrr/countmodel
Construction of rugged, ultrastable optical assemblies with optical component alignment at the few microradian level
A method for constructing quasimonolithic, precision-aligned optical assemblies is presented. Hydroxide-catalysis bonding is used, adapted to allow optimization of component fine alignment prior to the bond setting. We demonstrate the technique by bonding a fused silica mirror substrate to a fused silica baseplate. In-plane component placement at the submicrometer level is achieved, resulting in angular control of a reflected laser beam at the sub-10-ÎŒrad level. Within the context of the LISA Pathfinder mission, the technique has been demonstrated as suitable for use in space-flight applications. It is expected that there will also be applications in a wide range of areas where accuracy, stability, and strength of optical assemblies are important
What triggers galaxy transformations? The environments of post-starburst galaxies
(abridged) There are good observational reasons to believe that the
progenitors of red galaxies have undergone starbursts, followed by a
post-starburst phase. We investigate the environments of post-starburst
galaxies by measuring \textsl{(1)} number densities in
radius comoving spheres, \textsl{(2)} transverse distances to nearest
Virgo-like galaxy clusters, and \textsl{(3)} transverse distances to nearest
luminous-galaxy neighbors. We compare the post-starburst galaxies to currently
star-forming galaxies identified solely by A-star excess or \Halpha emission.
We find that post-starburst galaxies are in the same kinds of environments as
star-forming galaxies; this is our ``null hypothesis''. More importantly, we
find that at each value of the A-star excess, the star-forming and
post-starburst galaxies lie in very similar distributions of environment. The
only deviations from our null hypothesis are barely significant: a slight
deficit of post-starburst galaxies (relative to the star-forming population) in
very low-density regions, a small excess inside the virial radii of clusters,
and a slight excess with nearby neighbors. None of these effects is strong
enough to make the post-starburst galaxies a high-density phenomenon, or to
argue that the starburst events are primarily triggered by external tidal
impulses (e.g., from close passages of massive galaxies). The small excess
inside cluster virial radii suggests that some post-starbursts are triggered by
interactions with the intracluster medium, but this represents a very small
fraction of all post-starburst galaxies.Comment: ApJ in pres
Comparison of opioid prescribing by dentists in the United States and England
Importance: The United States consumes most of the opioids worldwide despite representing a small portion of the world\u27s population. Dentists are one of the most frequent US prescribers of opioids despite data suggesting that nonopioid analgesics are similarly effective for oral pain. While oral health and dentist use are generally similar between the United States and England, it is unclear how opioid prescribing by dentists varies between the 2 countries.
Objective: To compare opioid prescribing by dentists in the United States and England.
Design, Setting, and Participants: Cross-sectional study of prescriptions for opioids dispensed from outpatient pharmacies and health care settings between January 1 and December 31, 2016, by dentists in the United States and England. Data were analyzed from October 2018 to January 2019.
Exposures: Opioids prescribed by dentists.
Main Outcomes and Measures: Proportion and prescribing rates of opioid prescriptions.
Results: In 2016, the proportion of prescriptions written by US dentists that were for opioids was 37 times greater than the proportion written by English dentists. In all, 22.3% of US dental prescriptions were opioids (11.4 million prescriptions) compared with 0.6% of English dental prescriptions (28âŻ082 prescriptions) (difference, 21.7%; 95% CI, 13.8%-32.1%; Pâ\u3câ.001). Dentists in the United States also had a higher number of opioid prescriptions per 1000 population (35.4 per 1000 US population [95% CI, 25.2-48.7 per 1000 population] vs 0.5 per 1000 England population [95% CI, 0.03-3.7 per 1000 population]) and number of opioid prescriptions per dentist (58.2 prescriptions per dentist [95% CI, 44.9-75.0 prescriptions per dentist] vs 1.2 prescriptions per dentist [95% CI, 0.2-5.6 prescriptions per dentist]). While the codeine derivative dihydrocodeine was the sole opioid prescribed by English dentists, US dentists prescribed a range of opioids containing hydrocodone (62.3%), codeine (23.2%), oxycodone (9.1%), and tramadol (4.8%). Dentists in the United States also prescribed long-acting opioids (0.06% of opioids prescribed by US dentists [6425 prescriptions]). Long-acting opioids were not prescribed by English dentists.
Conclusions and Relevance: This study found that in 2016, dentists in the United States prescribed opioids with significantly greater frequency than their English counterparts. Opioids with a high potential for abuse, such as oxycodone, were frequently prescribed by US dentists but not prescribed in England. These results illustrate how 1 source of opioids differs substantially in the United States vs England. To reduce dental opioid prescribing in the United States, dentists could adopt measures similar to those used in England, including national guidelines for treating dental pain that emphasize prescribing opioids conservatively
Submillimeter Observations of the Ultraluminous BAL Quasar APM 08279+5255
With an inferred bolometric luminosity of 5\times10^{15}{\rm \lsun}, the
recently identified z=3.87, broad absorption line quasar APM 08279+5255 is
apparently the most luminous object currently known. As half of its prodigious
emission occurs in the infrared, APM 08279+5255 also represents the most
extreme example of an Ultraluminous Infrared Galaxy. Here, we present new
submillimeter observations of this phenomenal object; while indicating that a
vast quantity of dust is present, these data prove to be incompatible with
current models of emission mechanisms and reprocessing in ultraluminous
systems. The influence of gravitational lensing upon these models is considered
and we find that while the emission from the central continuum emitting region
may be significantly enhanced, lensing induced magnification cannot easily
reconcile the models with observations. We conclude that further modeling,
including the effects of any differential magnification is required to explain
the observed emission from APM 08279+5255.Comment: 12 Pages with Two figures. Accepted for publication in the
Astrophysical Journal Letter
The H-alpha and Infrared Star Formation Rates for the Nearby Field Galaxy Survey
We investigate the H-alpha and infrared star formation rate (SFR) diagnostics
for galaxies in the Nearby Field Galaxy Survey (NFGS). For the 81 galaxies in
our sample, we derive H-alpha fluxes (included here) from integrated spectra.
There is a strong correlation between the ratio of far-infrared to optical
luminosities L(FIR)/L(H-alpha) and the extinction E(B-V) measured with the
Balmer decrement. Before reddening correction, the SFR(IR) and SFR(H-alpha) are
related to each other by a power-law. Correction of the SFR(H-alpha) for
extinction using the Balmer decrement and a classical reddening curve both
reduces the scatter in the SFR(IR)-SFR(H-alpha) correlation and results in a
much closer agreement (within ~10%) between the two SFR indicators. This SFR
relationship spans 4 orders of magnitude and holds for all Hubble types with
IRAS detections in the NFGS. A constant ratio between the SFR(IR) and
SFR(H-alpha) for all Hubble types, including early types (S0-Sab), suggests
that the IR emission in all of these objects results from a young stellar
population.Comment: 23 pages, 5 figures, 1 table. Accepted for publication in the
Astronomical Journal. V2: Important changes: IRAS fluxes updated. Only
moderate and good quality IRAS FIR fluxes are now used, resulting in slight
changes to the equations and figures. The IR and H-alpha SFRs now agree to
within ~10%, rather than ~30% as quoted previousl
The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing
Kinetoplastid parasitesâtrypanosomes and leishmaniasâinfect millions of humans and cause economically devastating diseases of livestock, and the few existing drugs have serious deficiencies. Benzoxaborole-based compounds are very promising potential novel anti-trypanosomal therapies, with candidates already in human and animal clinical trials. We investigated the mechanism of action of several benzoxaboroles, including AN7973, an early candidate for veterinary trypanosomosis. In all kinetoplastids, transcription is polycistronic. Individual mRNA 5'-ends are created by trans splicing of a short leader sequence, with coupled polyadenylation of the preceding mRNA. Treatment of Trypanosoma brucei with AN7973 inhibited trans splicing within 1h, as judged by loss of the Y-structure splicing intermediate, reduced levels of mRNA, and accumulation of peri-nuclear granules. Methylation of the spliced leader precursor RNA was not affected, but more prolonged AN7973 treatment caused an increase in S-adenosyl methionine and methylated lysine. Together, the results indicate that mRNA processing is a primary target of AN7973. Polyadenylation is required for kinetoplastid trans splicing, and the EC50 for AN7973 in T. brucei was increased three-fold by over-expression of the T. brucei cleavage and polyadenylation factor CPSF3, identifying CPSF3 as a potential molecular target. Molecular modeling results suggested that inhibition of CPSF3 by AN7973 is feasible. Our results thus chemically validate mRNA processing as a viable drug target in trypanosomes. Several other benzoxaboroles showed metabolomic and splicing effects that were similar to those of AN7973, identifying splicing inhibition as a common mode of action and suggesting that it might be linked to subsequent changes in methylated metabolites. Granule formation, splicing inhibition and resistance after CPSF3 expression did not, however, always correlate and prolonged selection of trypanosomes in AN7973 resulted in only 1.5-fold resistance. It is therefore possible that the modes of action of oxaboroles that target trypanosome mRNA processing might extend beyond CPSF3 inhibition
Ultraluminous infrared galaxies: mergers of sub-L* galaxies?
A sample of 27 low-redshift, mostly cool, ultraluminous infrared galaxies (ULIRGs) has been imaged at 1.6 ÎŒm with the Hubble Space Telescope (HST) Near-Infrared Camera and Multi-Object Spectrometer (NICMOS). The majority (67%) of the sample's galaxies are multiple-nucleus galaxies with projected separations of up to 17 kpc, and the rest of the sample (33%) are single-nucleus galaxies, as determined by the NICMOS angular resolution limit. The average observed, integrated (host+nucleus) H magnitude of our HST H sample ULIRGs is -24.3, slightly above that of an L* galaxy (MH = -24.2), and 52% of the sample's galaxies have sub-L* luminosities. The ULIRGs in the HST H sample are not generated as a result of the merging of two luminous (i.e., â„L*) spiral galaxies. Instead, the interactions and mergers occur in general between two, or in some cases more, less massive sub-L* (0.3-0.5L*) galaxies.
Only one out of the 49 nuclei identified in the entire HST H sample has the properties of a bright quasar-like nucleus. On average, the brightest nuclei in the HST H sample galaxies (i.e., cool ULIRGs) are 1.2 mag fainter than warm ULIRGs and low-luminosity Bright Quasar Survey quasars (BQS QSOs) and 2.6 mag fainter than high-luminosity BQS QSOs. Since the progenitor galaxies involved in the merger are sub-L* galaxies, the mass of the central black hole in these ULIRGs would be only about (1-2) Ă 107 Mâ, if the bulge-to-black hole mass ratio of nearby galaxies holds for ULIRGs. The estimated mass of the central black hole is similar to that of nearby Seyfert 2 galaxies but at least 1 order of magnitude lower than the massive black holes thought to be located at the center of high-luminosity QSOs. Massive nuclear starbursts with constant star formation rates of 10-40 Mâ yr-1 could contribute significantly to the nuclear H-band flux and are consistent with the observed nuclear H-band magnitudes of the ULIRGs in the HST H sample. An evolutionary merging scenario is proposed for the generation of the different types of ULIRGs and QSOs on the basis of the masses of the progenitors involved in the merging process. According to this scenario, cool ULIRGs would be the end product of the merging of two or more low-mass (0.3L*-0.5L*) disk galaxies. Warm ULIRGs and low-luminosity QSOs would be generated by a merger involving intermediate-mass (0.5 L*) disk galaxies. Under this scenario, warm ULIRGs could still be the dust-enshrouded phases of UV-bright low-luminosity QSOs, but cool ULIRGs, which are most ULIRGs, would not evolve into QSOs
Collective excitation spectrum of a disordered Hubbard model
We study the collective excitation spectrum of a d=3 site-disordered
Anderson-Hubbard model at half-filling, via a random-phase approximation (RPA)
about broken-symmetry, inhomogeneous unrestricted Hartree-Fock (UHF) ground
states. We focus in particular on the density and character of low-frequency
collective excitations in the transverse spin channel. In the absence of
disorder, these are found to be spin-wave-like for all but very weak
interaction strengths, extending down to zero frequency and separated from a
Stoner-like band, to which there is a gap. With disorder present, a prominent
spin-wave-like band is found to persist over a wide region of the
disorder-interaction phase plane in which the mean-field ground state is a
disordered antiferromagnet, despite the closure of the UHF single-particle gap.
Site resolution of the RPA excitations leads to a microscopic rationalization
of the evolution of the spectrum with disorder and interaction strength, and
enables the observed localization properties to be interpreted in terms of the
fraction of strong local moments and their site-differential distribution.Comment: 25 pages (revtex), 9 postscript figure
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