Relaxed Bell inequalities and Kochen-Specker theorems

The combination of various physically plausible properties, such as no signaling, determinism, and experimental free will, is known to be incompatible with quantum correlations. Hence, these properties must be individually or jointly relaxed in any model of such correlations. The necessary degrees of relaxation are quantified here, via natural distance and information-theoretic measures. This allows quantitative comparisons between different models in terms of the resources, such as the number of bits, of randomness, communication, and/or correlation, that they require. For example, measurement dependence is a relatively strong resource for modeling singlet state correlations, with only 1/15 of one bit of correlation required between measurement settings and the underlying variable. It is shown how various 'relaxed' Bell inequalities may be obtained, which precisely specify the complementary degrees of relaxation required to model any given violation of a standard Bell inequality. The robustness of a class of Kochen-Specker theorems, to relaxation of measurement independence, is also investigated. It is shown that a theorem of Mermin remains valid unless measurement independence is relaxed by 1/3. The Conway-Kochen 'free will' theorem and a result of Hardy are less robust, failing if measurement independence is relaxed by only 6.5% and 4.5%, respectively. An appendix shows the existence of an outcome independent model is equivalent to the existence of a deterministic model.Comment: 19 pages (including 3 appendices); v3: minor clarifications, to appear in PR

Snug Fit Crescent Wrench

The most commonly used brand of adjustable wrench, a Crescent Wrench, dates back to the early nineteen hundreds. The tolerances associated with the adjustable wheel used by the most common adjustable wrench designs allow the position of the lower jaw to vary while using the tool. These undesired fluctuations in the position of the lower jaw make it difficult to adjust the wrench to the desired position and keep it in position once the desired position is set. The proposed adjustable wrench design addresses the tolerance issues by constraining the lower jaw with a new mechanism. The mechanism makes minor sacrifices in simplicity to attain advantages in practicality. (Content removed due to patent of design.) In addition to the competitive advantages offered by the proposed adjustable wrench design, the ANSI standard strength rating for existing adjustable wrenches is maintained. The proposed adjustable wrench will likely cost more than standard adjustable wrenches, but the design upgrades appear to greatly outweigh the minor price increase. These design improvements benefit every kind of user, from a handyman to a mechanic. For these reasons, it is apparent that the proposed design successfully improves upon the design of a standard adjustable wrench

Subsonic longitudinal and lateral-directional characteristics of a forward-swept-wing fighter configuration at angles of attack up to 47 deg

Subsonic lateral-direction and longitudinal characteristics of a forward-swept-wing fighter configuration were examined in wind-tunnel tests at Mach numbers of 0.2 and 0.5 for angles of attack from -7 to 47 deg. and over a sidelslip range of +/- 15 deg. The effects of a canard, strakes, vertical tail, and leading- and trailing-edge flaps are examined. The canard and strakes both reduce asymmetric moments and side forces at zero sideslip for angles of attack up to about 30 deg. The canard has a small influence on lateral-directional stability; however, strakes produce a substantial reduction in lateral stability for angles of attack greater than about 20 deg. The vertical tail improves directional stability for angles of attack up to 30 deg. Deflection of the leading-edge flap to 20 deg. at high angles of attack on the strake and canard configurations degrades lateral and directional stability. Deflection of the trailing-edge flap to 20 deg. on the canard configuration generally increases lateral and directional stability at high angles of attack. Leading- and trailing-edge flaps on the wing-body and canard configurations are effective for increased lift only for angles of attack up to about 40 deg. The leading-edge flap remains effective on the strake configuration over the entire angle-of-attack range tested

Supporting Physics Teachers to Deliver the New High School Certificate Syllabus: What are the Priorities?

For the first time since 2000, the New South Wales High School Certificate (HSC) school-leavers\u27 Physics syllabus has been updated. Topics not taught in schools since 2000 have been reintroduced, the number of mandated equations has more than doubled, and students must now do 15 hours of individual or group investigations in both Years 11 and 12. The Vniversity of Wollongong (UOW) intends to support teachers in our local area by providing outreach and professional learning activities for teachers and students. To determine teachers\u27 priorities, we invited teachers to complete a short online survey. Respondents stated that they were very likely to access activities and resources, and that their top priorities were accredited professional learning workshops and support with depth studies

Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies.

Human cells express thousands of different surface proteins that can be used for cell classification, or to distinguish healthy and disease conditions. A method capable of profiling a substantial fraction of the surface proteome simultaneously and inexpensively would enable more accurate and complete classification of cell states. We present a highly multiplexed and quantitative surface proteomic method using genetically barcoded antibodies called phage-antibody next-generation sequencing (PhaNGS). Using 144 preselected antibodies displayed on filamentous phage (Fab-phage) against 44 receptor targets, we assess changes in B cell surface proteins after the development of drug resistance in a patient with acute lymphoblastic leukemia (ALL) and in adaptation to oncogene expression in a Myc-inducible Burkitt lymphoma model. We further show PhaNGS can be applied at the single-cell level. Our results reveal that a common set of proteins including FLT3, NCR3LG1, and ROR1 dominate the response to similar oncogenic perturbations in B cells. Linking high-affinity, selective, genetically encoded binders to NGS enables direct and highly multiplexed protein detection, comparable to RNA-sequencing for mRNA. PhaNGS has the potential to profile a substantial fraction of the surface proteome simultaneously and inexpensively to enable more accurate and complete classification of cell states

HI galaxies with little star formation: an abundance of LIERs

We present a sample of 91 HI galaxies with little or no star formation and discuss the analysis of the integral field unit (IFU) spectra of 28 of these galaxies. We identified HI galaxies from the HI Parkes All-Sky Survey Catalog (HICAT) with Wide-field Infrared Survey Explorer (WISE) colours consistent with low specific star formation (< 10$^{-10.4}$ yr$^{-1}$), and obtained optical IFU spectra with the Wide-Field Spectrograph (WiFeS). Visual inspection of the PanSTARRS, Dark Energy Survey, and Carnegie-Irvine imaging of 62 galaxies reveals that at least 32 galaxies in the sample have low levels of star formation, primarily in arms/rings. New IFU spectra of 28 of these galaxies reveal 3 galaxies with central star formation, 1 galaxy with low-ionisation nuclear emission-line regions (LINERs), 20 with extended low-ionisation emission-line regions (LIERs) and 4 with high excitation Seyfert (Sy) emission. From the spectroscopic analysis of HI-selected galaxies with little star formation, we conclude that 75% of this population are LINERs/LIERs

Caltech Faint Field Galaxy Redshift Survey IX: Source detection and photometry in the Hubble Deep Field Region

Detection and photometry of sources in the U_n, G, R, and K_s bands in a 9x9 arcmin^2 region of the sky, centered on the Hubble Deep Field, are described. The data permit construction of complete photometric catalogs to roughly U_n=25, G=26, R=25.5 and K_s=20 mag, and significant photometric measurements somewhat fainter. The galaxy number density is 1.3x10^5 deg^{-2} to R=25.0 mag. Galaxy number counts have slopes dlog N/dm=0.42, 0.33, 0.27 and 0.31 in the U_n, G, R and K_s bands, consistent with previous studies and the trend that fainter galaxies are, on average, bluer. Galaxy catalogs selected in the R and K_s bands are presented, containing 3607 and 488 sources, in field areas of 74.8 and 59.4 arcmin^2, to R=25.5 and and K_s=20 mag.Comment: Accepted for publication in ApJS; some tables and slightly nicer figures available at http://www.sns.ias.edu/~hogg/deep

The First Ultra-cool Brown Dwarf Discovered by the Wide-field Infrared Survey Explorer

We report the discovery of the first new ultra-cool brown dwarf (BDs) found with the Wide-field Infrared Survey Explorer (WISE). The object’s preliminary designation is WISEPC J045853.90+643451.9. Follow-up spectroscopy with the LUCIFER instrument on the Large Binocular Telescope indicates that it is a very late-type T dwarf with a spectral type approximately equal to T9. Fits to an IRTF/SpeX 0.8–2.5 μm spectrum to the model atmospheres of Marley and Saumon indicate an effective temperature of approximately 600 K as well as the presence of vertical mixing in its atmosphere. The new BD is easily detected by WISE, with a signal-to-noise ratio of ~36 at 4.6 μm. Current estimates place it at a distance of 6–10 pc. This object represents the first in what will likely be hundreds of nearby BDs found by WISE that will be suitable for follow-up observations, including those with the James Webb Space Telescope. One of the two primary scientific goals of the WISE mission is to find the coolest, closest stars to our Sun; the discovery of this new BD proves that WISE is capable of fulfilling this objective

Heme metabolism genes Downregulated in COPD Cachexia.

IntroductionCachexia contributes to increased mortality and reduced quality of life in Chronic Obstructive Pulmonary Disease (COPD) and may be associated with underlying gene expression changes. Our goal was to identify differential gene expression signatures associated with COPD cachexia in current and former smokers.MethodsWe analyzed whole-blood gene expression data from participants with COPD in a discovery cohort (COPDGene, N = 400) and assessed replication (ECLIPSE, N = 114). To approximate the consensus definition using available criteria, cachexia was defined as weight-loss &gt; 5% in the past 12 months or low body mass index (BMI) (&lt; 20 kg/m2) and 1/3 criteria: decreased muscle strength (six-minute walk distance &lt; 350 m), anemia (hemoglobin &lt; 12 g/dl), and low fat-free mass index (FFMI) (&lt; 15 kg/m2 among women and &lt; 17 kg/m2 among men) in COPDGene. In ECLIPSE, cachexia was defined as weight-loss &gt; 5% in the past 12 months or low BMI and 3/5 criteria: decreased muscle strength, anorexia, abnormal biochemistry (anemia or high c-reactive protein (&gt; 5 mg/l)), fatigue, and low FFMI. Differential gene expression was assessed between cachectic and non-cachectic subjects, adjusting for age, sex, white blood cell counts, and technical covariates. Gene set enrichment analysis was performed using MSigDB.ResultsThe prevalence of COPD cachexia was 13.7% in COPDGene and 7.9% in ECLIPSE. Fourteen genes were differentially downregulated in cachectic versus non-cachectic COPD patients in COPDGene (FDR &lt; 0.05) and ECLIPSE (FDR &lt; 0.05).DiscussionSeveral replicated genes regulating heme metabolism were downregulated among participants with COPD cachexia. Impaired heme biosynthesis may contribute to cachexia development through free-iron buildup and oxidative tissue damage

CAIRNS: The Cluster And Infall Region Nearby Survey II. Environmental Dependence of Infrared Mass-to-Light Ratios

CAIRNS (Cluster And Infall Region Nearby Survey) is a spectroscopic survey of the infall regions surrounding nine nearby rich clusters of galaxies. In Paper I, we used redshifts within \sim 10\Mpc of the centers of the clusters to determine the mass profiles of the clusters based on the phase space distribution of the galaxies. Here, we use 2MASS photometry and an additional \ncziinew redshifts to investigate the environmental dependence of near-infrared mass-to-light ratios. In the virial regions, the halo occupation function is non-linear; the number of bright galaxies per halo increases more slowly than the mass of the halo. On larger scales, the light contained in galaxies is less clustered than the mass in rich clusters. Specifically, the mass-to-light ratio inside the virial radius is a factor of $1.8\pm0.3$ larger than that outside the virial radius. This difference could result from changing fractions of baryonic to total matter or from variations in the efficiency of galaxy formation or disruption with environment. The average mass-to-light ratio $M/L_K = 53\pm 5 h$ implies $\Omega_m = 0.18\pm 0.03$ (statistical) using the luminosity density based on 2dFGRS data. These results are difficult to reconcile with independent methods which suggest higher $\Omega_m$. Reconciling these values by invoking bias requires that the typical value of $M/L_K$ changes significantly at densities of $\lesssim3\rho_c$.Comment: to appear in The Astronomical Journal, September 2004, 46 pages, 25 figure