Malagan ritual art on Tabar, New Ireland, Papua New Guinea

Malagan ritual art traditions of New Ireland have long been of interest to Western anthropologists, but have not before been considered in terms relevant to the New Irelanders themselves. This thesis documents the malagan ritual art traditions of Tabar, a group of three islands off the coast of New Ireland which is acknowledged as the traditional source of malagan, and analyses malagan through the terms of reference which were specified by the Tabar Islanders as part of condition for undertaking fieldwork. Two series of ritual ceremonies are described, a mortuary series and a commemorative series. Over 450 malagan descriptions within twenty two subtraditions have been recorded and are documented in an accompanying appendix. The social and cultural connections of malagan are described and analysed, then the indigenous taxonomic structure malagan is described and analysed. A new understanding of the nature of these subtraditions has resulted from this study

Cosmic homogeneity demonstrated with luminous red galaxies

We test the homogeneity of the Universe at $z\sim 0.3$ with the Luminous Red Galaxy (LRG) spectroscopic sample of the Sloan Digital Sky Survey. First, the mean number $N(R)$ of LRGs within completely surveyed LRG-centered spheres of comoving radius $R$ is shown to be proportional to $R^3$ at radii greater than $R\sim 70 h^{-1} \mathrm{Mpc}$. The test has the virtue that it does not rely on the assumption that the LRG sample has a finite mean density; its results show, however, that there \emph{is} such a mean density. Secondly, the survey sky area is divided into 10 disjoint solid angular regions and the fractional rms density variations of the LRG sample in the redshift range $0.2<z<0.35$ among these ($\sim 2\times10^7 h^{-3} \mathrm{Mpc^3}$) regions is found to be 7 percent of the mean density. This variance is consistent with typical biased \lcdm models and puts very strong constraints on the quality of SDSS photometric calibration.Comment: submitted to Ap

Medical Research and Incompetent Adults

The spectre of Nazi medical experimentation during the Second World War undoubtedly hangs over any discussion of medical research and incompetent adults. The concentration camp experiments denied the rights of people who would have been able to give or withhold consent but were, of course, not asked. The fears raised by the nature of these experiments has given rise to a real, understandable and genuine concern that research participants, particularly those who are vulnerable, may be abused through their participation. For example, Professors Kennedy and Grubb take the view that nontherapeutic research on incompetent adults is prohibited and go on to say that “given the history of Europe in the 1930s and 1940s which culminated in the Nuremberg Trials ... it is entirely understandable that some European countries would hold the view that an absolute prohibition was the only defensible [position].” The question that arises is whether prohibition is always the correct approach, or whether some forms of research should be permissible, recognising that strict protections will be necessary. We reflect upon the rigidity of the distinction between therapeutic and non-therapeutic research in the context of a research project that we undertook

Decreased NADPH oxidase expression and antioxidant activity in cachectic skeletal muscle

Background - Cancer cachexia is the progressive loss of skeletal muscle protein that contributes significantly to cancer morbidity and mortality. Evidence of antioxidant attenuation and the presence of oxidised proteins in patients with cancer cachexia indicate a role for oxidative stress. The level of oxidative stress in tissues is determined by an imbalance between reactive oxygen species production and antioxidant activity. This study aimed to investigate the superoxide generating NADPH oxidase (NOX) enzyme and antioxidant enzyme systems in murine adenocarcinoma tumour-bearing cachectic mice. Methods - Superoxide levels, mRNA levels of NOX enzyme subunits and the antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidise (GPx) and catalase was measured in the skeletal muscle of mice with cancer and cancer cachexia. Protein expression levels of NOX enzyme subunits and antioxidant enzyme activity was also measured in the same muscle samples. Results - Superoxide levels increased 1.4-fold in the muscle of mice with cancer cachexia, and this was associated with a decrease in mRNA of NOX enzyme subunits, NOX2, p40phox and p67phox along with the antioxidant enzymes SOD1, SOD2 and GPx. Cancer cachexia was also associated with a 1.3-fold decrease in SOD1 and 2.0-fold decrease in GPx enzyme activity. Conclusion - Despite increased superoxide levels in cachectic skeletal muscle, NOX enzyme subunits, NOX2, p40phox and p67phox, were downregulated along with the expression and activity of the antioxidant enzymes. Therefore, the increased superoxide levels in cachectic skeletal muscle may be attributed to the reduction in the activity of endogenous antioxidant enzymes

Selection and photometric properties of K+A galaxies

Two different simple measurements of galaxy star formation rate with different timescales are compared empirically on $156,395$ fiber spectra of galaxies with $r<17.77$ mag taken from the Sloan Digital Sky Survey in the redshift range $0.05<z<0.20$: a ratio \Aamp / \Kamp found by fitting a linear sum of an average old stellar poplulation spectrum (\Kamp) and average A-star spectrum (\Aamp) to the galaxy spectrum, and the equivalent width (EW) of the \Halpha emission line. The two measures are strongly correlated, but there is a small clearly separated population of outliers from the median correlation that display excess \Aamp /\Kamp relative to \Halpha EW. These ``K+A'' (or ``E+A'') galaxies must have dramatically decreased their star-formation rates over the last $\sim 1$ Gyr. The K+A luminosity distribution is very similar to that of the total galaxy population. The K+A population appears to be bulge-dominated, but bluer and higher surface-brightness than normal bulge-dominated galaxies; it appears that K+A galaxies will fade with time into normal bulge-dominated galaxies. The inferred rate density for K+A galaxy formation is $\sim 10^{-4} h^3 Mpc^{-3} Gyr^{-1}$ at redshift $z\sim 0.1$. These events are taking place in the field; K+A galaxies don't primarily lie in the high-density environments or clusters typical of bulge-dominated populations.Comment: submitted to Ap

NYU-VAGC: a galaxy catalog based on new public surveys

Here we present the New York University Value-Added Galaxy Catalog (NYU-VAGC), a catalog of local galaxies (mostly below a redshift of about 0.3) based on a set of publicly-released surveys (including the 2dFGRS, 2MASS, PSCz, FIRST, and RC3) matched to the Sloan Digital Sky Survey (SDSS) Data Release 2. Excluding areas masked by bright stars, the photometric sample covers 3514 square degrees and the spectroscopic sample covers 2627 square degrees (with about 85% completeness). Earlier, proprietary versions of this catalog have formed the basis of many SDSS investigations of the power spectrum, correlation function, and luminosity function of galaxies. We calculate and compile derived quantities (for example, K-corrections and structural parameters for galaxies). The SDSS catalog presented here is photometrically recalibrated, reducing systematic calibration errors across the sky from about 2% to about 1%. We include an explicit description of the geometry of the catalog, including all imaging and targeting information as a function of sky position. Finally, we have performed eyeball quality checks on a large number of objects in the catalog in order to flag deblending and other errors. This catalog is complementary to the SDSS Archive Servers, in that NYU-VAGC's calibration, geometrical description, and conveniently small size are specifically designed for studying galaxy properties and large-scale structure statistics using the SDSS spectroscopic catalog.Comment: accepted by AJ; full resolution version available at http://sdss.physics.nyu.edu/vagc/va_paper.ps; data files available at http://sdss.physics.nyu.edu/vagc

E. coli O157 on Scottish cattle farms: evidence of local spread and persistence using repeat cross-sectional data

&lt;b&gt;Background&lt;/b&gt;&lt;p&gt;&lt;/p&gt; Escherichia coli (E. coli) O157 is a virulent zoonotic strain of enterohaemorrhagic E. coli. In Scotland (1998-2008) the annual reported rate of human infection is 4.4 per 100,000 population which is consistently higher than other regions of the UK and abroad. Cattle are the primary reservoir. Thus understanding infection dynamics in cattle is paramount to reducing human infections.&lt;p&gt;&lt;/p&gt; A large database was created for farms sampled in two cross-sectional surveys carried out in Scotland (1998 - 2004). A statistical model was generated to identify risk factors for the presence of E. coli O157 on farms. Specific hypotheses were tested regarding the presence of E. coli O157 on local farms and the farms previous status. Pulsed-field gel electrophoresis (PFGE) profiles were further examined to ascertain whether local spread or persistence of strains could be inferred.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Results&lt;/b&gt;&lt;p&gt;&lt;/p&gt; The presence of an E. coli O157 positive local farm (average distance: 5.96km) in the Highlands, North East and South West, farm size and the number of cattle moved onto the farm 8 weeks prior to sampling were significant risk factors for the presence of E. coli O157 on farms. Previous status of a farm was not a significant predictor of current status (p = 0.398). Farms within the same sampling cluster were significantly more likely to be the same PFGE type (p &#60; 0.001), implicating spread of strains between local farms. Isolates with identical PFGE types were observed to persist across the two surveys, including 3 that were identified on the same farm, suggesting an environmental reservoir. PFGE types that were persistent were more likely to have been observed in human clinical infections in Scotland (p &#60; 0.001) from the same time frame.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Conclusions&lt;/b&gt;&lt;p&gt;&lt;/p&gt; The results of this study demonstrate the spread of E. coli O157 between local farms and highlight the potential link between persistent cattle strains and human clinical infections in Scotland. This novel insight into the epidemiology of Scottish E. coli O157 paves the way for future research into the mechanisms of transmission which should help with the design of control measures to reduce E. coli O157 from livestock-related sources