Strong HLA-DR expression in microsatellite stable carcinomas of the large bowel is associated with good prognosis

Progression of colorectal cancer may follow either of two main genetic routes: the chromosome- or microsatellite-instability pathways. Association between the patients' prognosis and microsatellite instability has been questioned. Improved survival has previously been found in patients with expression of HLA-DR antigens on their tumour cells. In this study, the expression of HLA-DR antigen was investigated by immunohistochemistry in 357 large bowel carcinomas stratified by microsatellite instability status. Sixteen per cent of the tumours showed strong HLA-DR expression and 35% had weak DR expression. We confirmed that patients with strong positive HLA-DR staining had improved survival (P<0.001) compared to patients with no HLA-DR expression. Strong epithelial HLA-DR staining was significantly associated with high level of microsatellite instability (P<0.001). In the subgroup of tumours with characteristics typical of the chromosomal instability phenotype, i.e. in microsatellite-stable tumours, the patients positive for the HLA-DR determinants showed better survival than those without HLA-DR expression. The protective effect of HLA-DR expression on survival was confirmed by multivariate analysis, both in the whole patient group and in the microsatellite-stable/microsatellite instability-low group. This might be explained by enhanced T-cell mediated anti-tumour immune responses against tumour cells in the HLA-DR positive tumours. The finding of better patient survival in the subgroup of strong HLA-DR positive microsatellite-stable tumours may have clinical implications for these patients

A História da Alimentação: balizas historiográficas

Os M. pretenderam traçar um quadro da História da Alimentação, não como um novo ramo epistemológico da disciplina, mas como um campo em desenvolvimento de práticas e atividades especializadas, incluindo pesquisa, formação, publicações, associações, encontros acadêmicos, etc. Um breve relato das condições em que tal campo se assentou faz-se preceder de um panorama dos estudos de alimentação e temas correia tos, em geral, segundo cinco abardagens Ia biológica, a econômica, a social, a cultural e a filosófica!, assim como da identificação das contribuições mais relevantes da Antropologia, Arqueologia, Sociologia e Geografia. A fim de comentar a multiforme e volumosa bibliografia histórica, foi ela organizada segundo critérios morfológicos. A seguir, alguns tópicos importantes mereceram tratamento à parte: a fome, o alimento e o domínio religioso, as descobertas européias e a difusão mundial de alimentos, gosto e gastronomia. O artigo se encerra com um rápido balanço crítico da historiografia brasileira sobre o tema

Using Idle Workstations to Implement Predictive Prefetching

The benefits of Markov-based predictive prefetching have been largely overshadowed by the overhead required to produce high quality predictions. While both theoretical and simulation results for prediction algorithms appear promising, substantial limitations exist in practice. This outcome can be partially attributed to the fact that practical implementations ultimately make compromises in order to reduce overhead. These compromises limit the level of algorithm complexity, the variety of access patterns, and the granularity of trace data the implementation supports. This paper describes the design and implementation of GMS-3P, an operating-system kernel extension that offloads prediction overhead to idle network nodes. GMS-3P builds on the GMS global memory system, which pages to and from remote workstation memory. In GMS-3P, the target node sends an on-line trace of an application’s page faults to an idle node that is running a Markov-based prediction algorithm. The prediction node then uses GMS to prefetch pages to the target node from the memory of other workstations in the network. Our preliminary results show that predictive prefetching can reduce remote-memory page fault time by 60 % or more and that by offloading prediction overhead to an idle node, GMS-3P can reduce this improved latency by between 24 % and 44%, depending on Markov-model order. 1

Abstract Implementing Cooperative Prefetching and Caching in a Globally-Managed Memory System

This paper presents cooperative prefetching and caching — the use of network-wide global resources (memories, CPUs, and disks) to support prefetching and caching in the presence of hints of future demands. Cooperative prefetching and caching effectively unites disk-latency reduction techniques from three lines of research: prefetching algorithms, cluster-wide memory management, and parallel I/O. When used together, these techniques greatly increase the power of prefetching relative to a conventional (nonglobal-memory) system. We have designed and implemented PGMS, a cooperative prefetching and caching system, under the Digital Unix operating system running on a 1.28 Gb/sec Myrinetconnected cluster of DEC Alpha workstations. Our measurements and analysis show that by using available global resources, cooperative prefetching can obtain significant speedups for I/O-bound programs. For example, for a graphics rendering application, our system achieves a speedup of 4.9 over a non-prefetching version of the same program, and a 3.1-fold improvement over that program using local-disk prefetching alone.

Abstract Implementing Cooperative Prefetching and Caching in a Globally-Managed Memory System

This paper presents cooperative prefetching and caching — the use of network-wide global resources (memories, CPUs, and disks) to support prefetching and caching in the presence of hints of future demands. Cooperative prefetching and caching effectively unites disk-latency reduction techniques from three lines of research: prefetching algorithms, cluster-wide memory management, and parallel I/O. When used together, these techniques greatly increase the power of prefetching relative to a conventional (nonglobal-memory) system. We have designed and implemented PGMS, a cooperative prefetching and caching system, under the Digital Unix operating system running on a 1.28 Gb/sec Myrinetconnected cluster of DEC Alpha workstations. Our measurements and analysis show that by using available global resources, cooperative prefetching can obtain significant speedups for I/O-bound programs. For example, for a graphics rendering application, our system achieves a speedup of 4.9 over a non-prefetching version of the same program, and a 3.1-fold improvement over that program using local-disk prefetching alone.