Near Infrared Spectroscopy Describes Physiologic Payback Associated With Excess Postexercise Oxygen Consumption in Healthy Controls and Children With Complex Congenital Heart Disease

Exercise creates a physiologic burden with recovery from such effort crucial to adaptation. Excess postexercise oxygen consumption (EPOC) refers to the body’s increased metabolic need after work. This investigation was designed to determine the role of near infrared spectroscopy (NIRS) in the description of exercise recovery in healthy controls (NL) and children with congenital heart disease (CHD). Subjects were recruited with exercise testing performed to exhaustion. Exercise time (EXT), heart rate (HR), and oxygen consumption (VO2) were measured. Four-site NIRS (brain, kidney, deltoid, and vastus lateralis) were measured during exercise and into recovery to establish trends. Fifty individuals were recruited for each group (NL = 26 boys and 24 girls; CHD = 33 boys and 17 girls). Significant differences existed between EXT, VO2, and peak HR (P \u3c 0.01). NIRS values were examined at four distinct intervals: rest, peak work, and 2 and 5 min after exercise. Significant cerebral hyperemia was seen in children with CHD post exercise when compared to normal individuals in whom redistribution patterns were directed to somatic muscles. These identified trends support an immediate compensation of organ systems to re-establish homeostasis in peripheral beds through enhanced perfusion. Noninvasive NIRS monitoring helps delineate patterns of redistribution associated with EPOC in healthy adolescents and children with CHD

Long term evolution of planetary systems with a terrestrial planet and a giant planet

We study the long term orbital evolution of a terrestrial planet under the gravitational perturbations of a giant planet. In particular, we are interested in situations where the two planets are in the same plane and are relatively close. We examine both possible configurations: the giant planet orbit being either outside or inside the orbit of the smaller planet. The perturbing potential is expanded to high orders and an analytical solution of the terrestrial planetary orbit is derived. The analytical estimates are then compared against results from the numerical integration of the full equations of motion and we find that the analytical solution works reasonably well. An interesting finding is that the new analytical estimates improve greatly the predictions for the timescales of the orbital evolution of the terrestrial planet compared to an octupole order expansion. Finally, we briefly discuss possible applications of the analytical estimates in astrophysical problems.Comment: Accepted for publication in MNRA

Spin-Dependent Antenna Splitting Functions

We consider parton showers based on radiation from QCD dipoles or `antennae'. These showers are built from 2->3 parton splitting processes. The question then arises of what functions replace the Altarelli-Parisi splitting functions in this approach. We give a detailed answer to this question, applicable to antenna showers in which partons carry definite helicity, and to both initial- and final-state emissions.Comment: 31 pages, 12 figure

The Four-Loop Planar Amplitude and Cusp Anomalous Dimension in Maximally Supersymmetric Yang-Mills Theory

We present an expression for the leading-color (planar) four-loop four-point amplitude of N=4 supersymmetric Yang-Mills theory in 4-2 e dimensions, in terms of eight separate integrals. The expression is based on consistency of unitarity cuts and infrared divergences. We expand the integrals around e=0, and obtain analytic expressions for the poles from 1/e^8 through 1/e^4. We give numerical results for the coefficients of the 1/e^3 and 1/e^2 poles. These results all match the known exponentiated structure of the infrared divergences, at four separate kinematic points. The value of the 1/e^2 coefficient allows us to test a conjecture of Eden and Staudacher for the four-loop cusp (soft) anomalous dimension. We find that the conjecture is incorrect, although our numerical results suggest that a simple modification of the expression, flipping the sign of the term containing zeta_3^2, may yield the correct answer. Our numerical value can be used, in a scheme proposed by Kotikov, Lipatov and Velizhanin, to estimate the two constants in the strong-coupling expansion of the cusp anomalous dimension that are known from string theory. The estimate works to 2.6% and 5% accuracy, providing non-trivial evidence in support of the AdS/CFT correspondence. We also use the known constants in the strong-coupling expansion as additional input to provide approximations to the cusp anomalous dimension which should be accurate to under one percent for all values of the coupling. When the evaluations of the integrals are completed through the finite terms, it will be possible to test the iterative, exponentiated structure of the finite terms in the four-loop four-point amplitude, which was uncovered earlier at two and three loops.Comment: 72 pages, 15 figures, v2 minor correction

Near Infrared Spectroscopic Monitoring During Cardiopulmonary Exercise Testing Detects Anaerobic Threshold

Cardiopulmonary exercise testing (CPET) provides assessment of the integrative responses involving the pulmonary, cardiovascular, and skeletal muscle systems. Application of exercise testing remains limited to children who are able to understand and cooperate with the exercise protocol. Near-infrared spectroscopy (NIRS) provides a noninvasive, continuous method to monitor regional tissue oxygenation (rSO2). Our specific aim was to predict anaerobic threshold (AT) during CPET noninvasively using two-site NIRS monitoring. Achievement of a practical noninvasive technology for estimating AT will increase the compatibility of CPET. Patients without structural or acquired heart disease were eligible for inclusion if they were ordered to undergo CPET by a cardiologist. Data from 51 subjects was analyzed. The ventilatory anaerobic threshold (VAT) was computed on VCO2 and respiratory quotient post hoc using the standard V-slope method. The inflection points of the regional rSO2 time-series were identified as the noninvasive regional NIRS AT for each of the two monitored regions (cerebral and kidney). AT calculation made using an average of kidney and brain NIRS matched the calculation made by VAT for the same patient. Two-site NIRS monitoring of visceral organs is a predictor of AT

PATHOGENESIS OF CHRONIC DISEASE ASSOCIATED WITH PERSISTENT LYMPHOCYTIC CHORIOMENINGITIS VIRAL INFECTION : II. RELATIONSHIP OF THE ANTI-LYMPHOCYTIC CHORIOMENINGITIS IMMUNE RESPONSE TO TISSUE INJURY IN CHRONIC LYMPHOCYTIC CHORIOMENINGITIS DISEASE

Tissue injury (chronic disease) associated with persistent LCM infection is apparently caused by the host immune response to the virus. Employing parabiosis or cell transfer from hyperimmune donors to isologous virus carriers, the tissue injury of chronic disease could be initiated and/or intensified. Furthermore, the transfer of anti-LCM antibody to SWR/J carrier mice results in acute necrotizing inflammatory lesions in regions of viral persistence, followed by chronic mononuclear infiltrates quite similar to those seen after the transfer of immune cells. The pathogenesis of the nonglomerular tissue injury of chronic LCM disease is apparently at least in part related to the interaction of circulating anti-LCM antibody with viral antigen at the tissue site. Trapping of circulating virus-antibody complexes in the glomerular filter is apparently the major cause of the glomerulonephritis

PATHOGENESIS OF CHRONIC DISEASE ASSOCIATED WITH PERSISTENT LYMPHOCYTIC CHORIOMENINGITIS VIRAL INFECTION : I. RELATIONSHIP OF ANTIBODY PRODUCTION TO DISEASE IN NEONATALLY INFECTED MICE

Mice infected shortly after birth with lymphocytic choriomeningitis (LCM) virus are not immunologically tolerant, although they carry the virus throughout life. These LCM carrier mice make anti-LCM antibody, which apparently complexes with viral antigen in the circulation and these complexes accumulate in the glomeruli. LCM carrier mice of different strains vary significantly as to concentration of detectable infectious virus in their tissue, amount and time of appearance of anti-LCM antibody, and development of an associated chronic disease. The chronic disease consists primarily of glomerulonephritis, focal hepatic necrosis, and disseminated lymphoid infiltrations. LCM carriers of the SWR/J strain contain high tissue concentrations of virus, considerable anti-LCM antibody detectable in the glomeruli by 3 wk to 2 months of age and develop chronic disease within the first 2–3 months of life. In contrast, C3H strain LCM carriers contain 1/1000 as much infectious virus, less detectable anti-LCM antibody, and have not, over a 24 month observation period, developed any detectable disease. B10D2 old and new carrier mice with intermediate amounts of virus develop chronic disease during the latter half of the first year of life. The pathogenesis of the glomerulonephritis of chronic LCM disease is apparently related to the formation of circulating virus-antibody complexes which are trapped in the glomerular filter. There is no evidence for direct glomerular injury by the virus nor for any autoimmune response by the host

DISEASE ACCOMPANYING IN UTERO VIRAL INFECTION : THE ROLE OF MATERNAL ANTIBODY IN TISSUE INJURY AFTER TRANSPLACENTAL INFECTION WITH LYMPHOCYTIC CHORIOMENINGITIS VIRUS

Early, after in utero infection with LCM virus, SWR/J and HA/ICR mice developed manifestations of immune complex disease. Observations based on nursing such mice with virus-infected, immune, or noninfected mouse mothers indicated that maternal antiviral antibody was responsible for the early immune complex glomerulonephritis. Despite comparable viral persistance, in utero-infected offspring failed to develop glomerulonephritis when nursed by noninfected mouse mothers, but did when suckled by virus-infected mouse mothers. Nursing by mouse mothers carrying high titers of anti-LCM viral antibody markedly enhanced the Ig glomerular deposits and the resultant nephritis

D = 5 maximally supersymmetric Yang-Mills theory diverges at six loops

The connection of maximally supersymmetric Yang-Mills theory to the (2,0) theory in six dimensions has raised the possibility that it might be perturbatively ultraviolet finite in five dimensions. We test this hypothesis by computing the coefficient of the first potential ultraviolet divergence of planar (large N_c) maximally supersymmetric Yang-Mills theory in D = 5, which occurs at six loops. We show that the coefficient is nonvanishing. Furthermore, the numerical value of the divergence falls very close to an approximate exponential formula based on the coefficients of the divergences through five loops. This formula predicts the approximate values of the ultraviolet divergence at loop orders L > 6 in the critical dimension D = 4 + 6/L. To obtain the six-loop divergence we first construct the planar six-loop four-point amplitude integrand using generalized unitarity. The ultraviolet divergence follows from a set of vacuum integrals, which are obtained by expanding the integrand in the external momenta. The vacuum integrals are integrated via sector decomposition, using a modified version of the FIESTA program.Comment: 31 pages, revtex, 12 figure