Determination of MIC and Disk Diffusion Quality Control Guidelines for Meropenem–Vaborbactam, a Novel Carbapenem/Boronic Acid β-Lactamase Inhibitor Combination

Meropenem–vaborbactam is a carbapenem/cyclic boronic acid β-lactamase inhibitor combination primarily active against Gram-negative bacilli, including those harboring class A serine carbapenemases such as Klebsiella pneumoniae carbapenemase (KPC). A Clinical and Laboratory Standards Institute M23-A4 (Tier 2) quality control study established broth microdilution and disk diffusion ranges for reference strains. Two KPC-producing K. pneumoniae ATCC strains are recommended for quality control testing

Real-time determination of laser beam quality by modal decomposition

We present a real-time method to determine the beam propagation ratio M2 of laser beams. The all-optical measurement of modal amplitudes yields M2 parameters conform to the ISO standard method. The experimental technique is simple and fast, which allows to investigate laser beams under conditions inaccessible to other methods.Comment: 8 pages, 4 figures, published in Optics Expres

Offsets and the Path to Carbon Neutrality in Higher Education and Study Abroad

Professors Paul Sylvester, Early & Middle Grades Education, and Michael Di Giovine, Anthropology, in conversation with Bradley Flamm - Offsets and the Path to Carbon Neutrality in Higher Education and Study Abroa

Computational fluid dynamics modeling for fermentation risk reduction during technology transfer and risk understanding

Computational Fluid Dynamics modeling and in-depth scaling calculations have been utilized in partnership to generate data to support equipment design and facility fit during commercialization of a fermentation and primary recovery process for a vaccine candidate across multiple technical transfers. This analysis utilizing representative computer models for tank configurations, supplemented with traditional computational scaling approaches (ungassed P/V, gassed P/V, kLa, etc.), ensures full knowledge of a tank’s mixing and oxygen transfer capabilities allowing process understanding and robust manufacturing across technology transfer to multiple sites. Implementation of this approach across process steps as well as manufacturing sites allows increased knowledge prior to use in a process and/or prior to construction of a new vessel, therefore contributing to successful process transfer with reduced risks upon scale-up/scale-down and new facility introductions

NGT Slip Coaching - Übertragbarkeit des Konzepts auf weitere Länder und Streckenkategorien

DE: Das neue Slip Coaching-Verfahren kann dazu beitragen, auf existierender Infrastruktur ein verbessertes Angebot mit höherer Taktfrequenz, verringerten Reisezeiten sowie zusätzlichen Direktverbindungen umzusetzen. Insbesondere im Hochgeschwindigkeitsverkehr können signifikante Systemvorteile realisiert werden. In diesem Beitrag wird untersucht, inwieweit das Verfahren auf andere Länder und Streckentypen übertragbar ist. Anhand internationaler Beispiele wird gezeigt, dass der Nutzen gegenüber bestehenden Fahrplankonzepten stark von der Art und der Anzahl der zu bedienenden Zwischenhalte abhängt. Der Einsatz des Slip Coachings auf Hochgeschwindigkeitsstrecken mit mehreren Zwischenhalten zwischen zwei Knotenbahnhöfen wird als empfehlenswert angesehen. EN: The new slip coaching process can help to implement an improved service with higher frequency, reduced travel times and additional direct connections on existing infrastructure. Significant system advantages can be realized, especially in high-speed traffic. This paper examines the extent to which the method can be transferred to other countries and route types. Using international examples, it is shown that the benefits compared to existing timetable concepts depend strongly on the type and number of intermediate stops to be served. The use of slip coaching on high-speed lines with several intermediate stops between two nodal stations is considered recommendable

Mode-resolved gain analysis and lasing in multi-supermode multi-core fiber laser

Multi-core fibers (MCFs) with coupled-cores are attractive large-mode area (LMA) specialty fiber designs that support the propagation of a few transverse modes often called supermodes (SMs). Compared to other LMA fibers, the uniqueness of MCF arises from the higher degrees of design space offered by a multitude of core-array geometries, resulting in extended flexibility to tailor SM properties. To date, the use of MCF as gain media has focused on lasers that operate in only one selected SM, typically the lowest order in-phase SM, which considerably limited the potential of these multi-core structures. Here, we expand the potential of MCF lasers by investigating multi-SM amplification and lasing schemes. Amplifier and laser systems using a 7 coupled-cores Yb-doped MCF as gain medium were successfully designed and assembled. Individual SM could be decomposed using the correlation filter technique mode analysis and the modal amplification factors (gamma(i)) were recorded. With access to amplification characteristics of individual transverse modes, a monolithic MCF laser was demonstrated that operates simultaneously on the two SMs carrying the highest optical gain

Chronic myeloid leukemia and HIV-infection

The incidence of non-HIV-associated hematologic malignancies, including chronic myeloproliferative disorders, is increasing in HIV-infected (HIVþ) patients. This is thought to be due to prolonged survival in the era of highly active antiretroviral therapy (HAART). Previously, only six cases of chronic myeloid leukemia (CML) have been described in HIVþ individuals and limited information is available regarding the management of patients with concurrent CML and HIV- infection. We report three cases of CML in HIVþ patients who were treated with imatinib and HAART. Treatment was generally well tolerated, and cytogenetic response (complete in two patients) was achieved with follow-up ranging from 3 to 69 months. HIV viral load remained undetectable and CD4 cell counts were stable in all three patients. Concurrent treatment with imatinib and HAART can result in appropriate control of CML and HIV-infection as well as long-term survival