Psychological Network Analysis of General Self-Efficacy in High vs. Low Resilient Functioning Healthy Adults.

Resilience to stress has gained increasing interest by researchers from the field of mental health and illness and some recent studies have investigated resilience from a network perspective. General self-efficacy constitutes an important resilience factor. High levels of self-efficacy have shown to promote resilience by serving as a stress buffer. However, little is known about the role of network connectivity of self-efficacy in the context of stress resilience. The present study aims at filling this gap by using psychological network analysis to study self-efficacy and resilience. Based on individual resilient functioning scores, we divided a sample of 875 mentally healthy adults into a high and low resilient functioning group. To compute these scores, we applied a novel approach based on Partial Least Squares Regression on self-reported stress and mental health measures. Separately for both groups, we then estimated regularized partial correlation networks of a ten-item self-efficacy questionnaire. We compared three different global connectivity measures-strength, expected influence, and shortest path length-as well as absolute levels of self-efficacy between the groups. Our results supported our hypothesis that stronger network connectivity of self-efficacy would be present in the highly resilient functioning group compared to the low resilient functioning group. In addition, the former showed higher absolute levels of general self-efficacy. Future research could consider using partial least squares regression to quantify resilient functioning to stress and to study the association between network connectivity and resilient functioning in other resilience factors

Article Failure of Extinction of Fear Responses in Posttraumatic Stress Disorder: Evidence From Second-Order Conditioning

Objectives: Posttraumatic stress disorder (PTSD) is characterized by the re-experiencing of a traumatic event, although the trauma itself occurred in the past. The extinction of the traumatic response might be impeded if trauma reminders maintain fear responses by their association with the original trauma through second-order conditioning. Method: A differential conditioning paradigm with a trauma-specific picture, used as an acquired unconditioned stimulus, and graphic representations, used as conditioned stimuli, were employed in 14 PTSD patients, 15 trauma-exposed subjects without PTSD, and 15 healthy comparison subjects. The authors used event-related potentials of electroencephalogram (EEG), self-report measures, skin conductance responses, heart rate, and startle modulation to assess the differential conditioned response among subjects. Results: Trauma-exposed subjects with and without PTSD but not healthy comparison subjects showed successful differential conditioning to the trauma-relevant cue indicative of second-order conditioning. Only PTSD patients exhibited enhanced conditioned responses to the trauma reminder during acquisition and impaired extinction as evident in more negative evaluations of the conditioned stimuli associated with a trauma reminder as well as enhanced peripheral and brain responses. Conclusions: These findings suggest that PTSD may be maintained by second-order conditioning where trauma-relevant cues come to serve as unconditioned stimuli, thus generalizing enhanced emotional responses to many previously neutral cues and impeding extinction. The extinction deficit in PTSD patients observed in this study underlines the need for therapies focusing on the extinction of learned responses, such as behavioral treatment, with or without the addition of pharmacological substances that enhance the extinction of a learned response. (Am J Psychiatry 2007; 164: [1684][1685][1686][1687][1688][1689][1690][1691][1692] Duri ng the last decades, our understanding of the development and maintenance of anxiety disorders has improved by advances in the analysis of learning mechanisms such as Pavlovian conditioning (1). Pavlovian conditioning is a universal learning process present in humans and animals and is characterized by the acquisition of a conditioned response to an initially neutral stimulus, which becomes a conditioned stimulus (CS) by its association with a biologically relevant stimulus. The conditioned response is often, although not always, similar to the unconditioned response, which is the initial reaction to the unconditioned stimulus. In posttraumatic stress disorder (PTSD), a prototypical anxiety disorder, the trauma can be considered an unconditioned stimulus, and the continued fear response in PTSD patients can be considered a conditioned response (2, 3). PTSD has in fact been associated with enhanced acquisition and slower extinction of fear responses (4, 5). Furthermore, the observed enhanced peripheral (6), electrophysiological Second-order conditioning refers to the well-documented fact that the conditioned stimulus can acquire the properties of the unconditioned stimulus and elicits conditioned responses to new neutral stimuli that are associated with it (10). In PTSD, trauma-related cues might over time come to serve as unconditioned stimuli and thus acquire the properties of the original trauma. Stimulus generalization with an enlarged fear-related memory network might ensue (11), and the extinction of conditioned responses may be impaired by the involuntary re-experiencing of the traumatic event. Consistent with conditioning theories of PTSD, several studies have investigated Pavlovian conditioning in PTS

Experimental induction of state rumination: A study evaluating the efficacy of goal-cueing task in different experimental settings

Based on previous studies, the present four experiments (total N = 468) aimed at investigating the effectivity of rumination induction in different experimental settings. We were particularly interested in rumination in the context of individual goal achievement and tested whether an instruction that referred to unresolved goals had a direct observable effect on state rumination. For this purpose, participants were asked to identify, evaluate, and focus on a personally relevant goal that was previously unresolved and still bothered them. In Experiment 1a to 1c, we compared three different modifications of the unresolved condition with shortened instructions with the elaborated unresolved condition and an additional control condition that did not refer to goals. In general, the results were mixed, but basically confirmed the effectiveness of the method used. Finally, in Experiment 2, we compared the two most promising versions of the unresolved condition and, by adding a goal-related control condition, we examined which control condition was best suited to maximize effects related to state rumination in future research. Results of various mixed ANOVAs demonstrated that a shortened version (in terms of shortened audio instructions) of the unresolved condition could be used as well as the original unresolved condition to induce reliable state rumination. The significance of the effects obtained with this method for real-life applications as well as approaches for future research are discussed

Altered Functional Connectivity between Emotional and Cognitive Resting State Networks in Euthymic Bipolar I Disorder Patients

<div><p>Bipolar disorder is characterized by a functional imbalance between hyperactive ventral/limbic areas and hypoactive dorsal/cognitive brain regions potentially contributing to affective and cognitive symptoms. Resting-state studies in bipolar disorder have identified abnormal functional connectivity between these brain regions. However, most of these studies used a seed-based approach, thus restricting the number of regions that were analyzed. Using data-driven approaches, researchers identified resting state networks whose spatial maps overlap with frontolimbic areas such as the default mode network, the frontoparietal networks, the salient network, and the meso/paralimbic network. These networks are specifically engaged during affective and cognitive tasks and preliminary evidence suggests that functional connectivity within and between some of these networks is impaired in bipolar disorder. The present study used independent component analysis and functional network connectivity approaches to investigate functional connectivity within and between these resting state networks in bipolar disorder. We compared 30 euthymic bipolar I disorder patients and 35 age- and gender-matched healthy controls. Inter-network connectivity analysis revealed increased functional connectivity between the meso/paralimbic and the right frontoparietal network in bipolar disorder. This abnormal connectivity pattern did not correlate with variables related to the clinical course of the disease. The present finding may reflect abnormal integration of affective and cognitive information in ventral-emotional and dorsal-cognitive networks in euthymic bipolar patients. Furthermore, the results provide novel insights into the role of the meso/paralimbic network in bipolar disorder.</p></div

How to regulate emotion? Neural networks for reappraisal and distraction

The regulation of emotion is vital for adaptive behavior in a social environment. Different strategies may be adopted to achieve successful emotion regulation, ranging from attentional control (e.g., distraction) to cognitive change (e.g., reappraisal). However, there is only scarce evidence comparing the different regulation strategies with respect to their neural mechanisms and their effects on emotional experience. We, therefore, directly compared reappraisal and distraction in a functional magnetic resonance imaging study with emotional pictures. In the distraction condition participants performed an arithmetic task, while they reinterpreted the emotional situation during reappraisal to downregulate emotional intensity. Both strategies were successful in reducing subjective emotional state ratings and lowered activity in the bilateral amygdala. Direct contrasts, however, showed a stronger decrease in amygdala activity for distraction when compared with reappraisal. While both strategies relied on common control areas in the medial and dorsolateral prefrontal and inferior parietal cortex, the orbitofrontal cortex was selectively activated for reappraisal. In contrast, the dorsal anterior cingulate and large clusters in the parietal cortex were active in the distraction condition. Functional connectivity patterns of the amygdala activation confirmed the roles of these specific activations for the 2 emotion regulation strategies