Perinatal and newborn care in a two years retrospective study in a first level peripheral hospital in Sicily (Italy)

BACKGROUND: Two hundred seventy-five thousand maternal deaths, 2.7 million neonatal deaths, and 2.6 million stillbirths have been estimated in 2015 worldwide, almost all in low-income countries (LICs). Moreover, more than 20 million severe disabilities result from the complications of pregnancy, childbirth or its management each year. A significant decrease of mortality/morbidity rates could be achieved by providing effective perinatal and newborn care also in high-income countries (HICs), especially in peripheral hospitals and/or rural areas, where the number of childbirths per year is often under the minimal threshold recognized by the reference legislation. We report on a 2 years retrospective cohort study, conducted in a first level peripheral hospital in Cefalù, a small city in Sicily (Italy), to evaluate care provided and mortality/morbidity rates. The proposed goal is to improve the quality of care, and the services that peripheral centers can offer. METHODS: We collected data from maternity and neonatal records, over a 2-year period from January 2017 to December 2018. The informations analyzed were related to demographic features (age, ethnicity/origin area, residence, educational level, marital status), diagnosis at admission (attendance of birth training courses, parity, type of pregnancy, gestational age, fetal presentation), mode of delivery, obstetric complications, the weight of the newborns, their feeding and eventual transfer to II level hospitals, also through the Neonatal Emergency Transport Service, if the established criteria were present. RESULTS: Eight hundred sixteen women were included (age 18-48 years). 179 (22%) attended birth training courses. 763 (93%) were Italian, 53 foreign (7%). 175 (21%) came from outside the province of Palermo. Eight hundred ten were single pregnancies, 6 bigeminal; 783 were at term (96%), 33 preterm (4%, GA 30-41 WG); 434 vaginal deliveries (53%), 382 caesarean sections (47%). One maternal death and 28 (3%) obstetric complications occurred during the study period. The total number of children born to these women was 822, 3 of which stillbirths (3.6‰). 787 (96%) were born at term (>37WG), 35 preterm (4%), 31 of which late preterm. Twenty-one newborns (2.5%) were transferred to II level hospitals. Among them, 3 for moderate/severe prematurity, 18 for mild prematurity/other pathology. The outcome was favorable for all women (except 1 hysterectomy) and the newborns transferred, and no neonatal deaths occurred in the biennium under investigation. Of the remaining 798 newborns, 440 were breastfed at discharge (55%), 337 had a mixed feeding (breastfed/formula fed, 42%) and 21 were formula fed (3%). CONCLUSIONS: Although the minimal standard of adequate perinatal care in Italy is >500 childbirths/year, the aims of the Italian legislation concern the rationalization of birth centers as well as the structural, technological and organizational improvement of health facilities. Therefore, specific contexts and critical areas need to be identified and managed. Adequate resources and intervention strategies should be addressed not only to perinatal emergencies, but also to the management of mild prematurity/pathology, especially in vulnerable populations for social or orographic reasons. The increasing availability and spread of health care offers, even in HICs, cannot be separated from the goal of quality of care, which is an ethic and public health imperative

Radio polarization maps of shell-type SNRs II. Sedov models with evolution of turbulent magnetic field

Polarized radio emission has been mapped with great detail in several Galactic supernova remnants (SNRs), but has not yet been exploited to the extent it deserves. We have developed a method to model maps of the Stokes parameters for shell-like SNRs during their Sedov evolution phase. At first, 3-dimensional structure of a SNR has been computed, by modeling the distribution of the magnetohydrodynamic parameters and of the accelerated particles. The generation and dissipation of the turbulent component of magnetic field everywhere in SNR are also considered taking into account its interaction with accelerated particles. Then, in order to model the emission, we have used a generalization of the classical synchrotron theory, valid for the case in which the magnetic field has ordered and disordered components. Finally, 2-dimensional projected maps have been derived, for different orientations of SNR and of interstellar magnetic field with respect to the observer. An important effect to consider is the Faraday rotation of the polarization planes inside the SNR interior. In this paper we present details of the model, and describe general properties of the images.Comment: accepted in MNRA

Modeling non-thermal emission from stellar bow shocks

Runaway O- and early B-type stars passing throughout the interstellar medium at supersonic velocities and characterized by strong stellar winds may produce bow shocks that can serve as particle acceleration sites. Previous theoretical models predict the production of high energy photons by non-thermal radiative processes, but their efficiency is still debated. We aim to test and explain the possibility of emission from the bow shocks formed by runaway stars traveling through the interstellar medium by using previous theoretical models. We apply our model to AE Aurigae, the first reported star with an X-ray detected bow shock, to BD+43 3654, in which the observations failed in detecting high energy emission, and to the transition phase of a supergiant star in the late stages of its life.From our analysis, we confirm that the X-ray emission from the bow shock produced by AE Aurigae can be explained by inverse Compton processes involving the infrared photons of the heated dust. We also predict low high energy flux emission from the bow shock produced by BD+43 3654, and the possibility of high energy emission from the bow shock formed by a supergiant star during the transition phase from blue to red supergiant.Bow shock formed by different type of runaway stars are revealed as a new possible source of high energy photons in our neighbourhood

Investigation of heatless adsorption technology for carbon dioxide control for manned spacecraft

Heatless adsorption techniques for carbon dioxide removal in manned spacecraf

Plasma ACTH, α-MSH and cortisol variations in the dog during the oestrous cycle in different photoperiods

The hypothalamic-pituitary-adrenal axis (HPA) is a complex system regulated by multiple factors.Sexual dimorphism of this axis has been described in different species under physiological conditions and it hasbeen proposed that sexual hormones could have an effect on it. There are only a few reports about sex-linkedvariations in HPA axis hormones in the dog. Thus, studying the impact of sexual hormones on the HPA axis wouldbroaden the knowledge about its function in this species. Therefore, the objective of this study was to determinewhether there are variations in HPA plasma hormones (ACTH, alfa-melanocyte-stimulating hormone [α-MSH]and cortisol) according to the sex and photoperiod (positive or negative photoperiod were considered when theduration of the light hours of the day was more than 12 or less than 12, respectively) under basal conditions (likeanoestrus) and throughout the oestrous cycle in the female dog. The population under study consisted of 11 intactfemale and 14 intact male dogs. Under basal conditions neither ACTH nor α-MSH concentrations showed differencesbetween sexes and different photoperiods. Cortisol showed greater values in the negative photoperiod thanin the positive, both in females and males (P = 0.03 and P = 0.015, respectively). Throughout the oestrous cycle,all the studied hormones showed variations (P < 0.0001). The greatest concentrations of ACTH were observed atproestrus, while α-MSH and cortisol showed their greatest concentrations at oestrus. The three hormones decreasedin diestrus. ACTH and cortisol concentrations were higher in the negative photoperiod (P = 0.04 and P < 0.0001,respectively), while α-MSH concentrations were higher in the positive photoperiod (P = 0.012). In the group offemales oestradiol and progesterone correlated with ACTH (r = 0.75, P < 0.0001; r = 0.34, P < 0.01, respectively),α-MSH (r = 0.49, P < 0.0001; r = 0.52, P < 0.0001, respectively) and cortisol (r = 0.33, P < 0.01; r = 0.5, P < 0.0001,respectively). These results show that in females, HPA axis hormones vary during the oestrous cycle in relation tooestradiol and progesterone fluctuations. The ACTH, α-MSH and cortisol concentrations also showed differencesbetween photoperiods in females, but only cortisol did so in males. These findings suggest that sexual hormonescould have an effect on the HPA axis. Further research needs to be done to fully understand this interaction andthe mechanisms involved.Fil: Gallelli, María Florencia. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Monachesi, N.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Miceli, Diego Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Cabrera Battler, M. F.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Gomez, N. V.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Meikle, A.. Universidad de Montevideo; UruguayFil: Castillo, V, A.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentin

AE Aurigae: first detection of non-thermal X-ray emission from a bow shock produced by a runaway star

Runaway stars produce shocks when passing through interstellar medium at supersonic velocities. Bow shocks have been detected in the mid-infrared for several high-mass runaway stars and in radio waves for one star. Theoretical models predict the production of high-energy photons by non-thermal radiative processes in a number sufficiently large to be detected in X-rays. To date, no stellar bow shock has been detected at such energies. We present the first detection of X-ray emission from a bow shock produced by a runaway star. The star is AE Aur, which was likely expelled from its birthplace by the encounter of two massive binary systems and now is passing through the dense nebula IC 405. The X-ray emission from the bow shock is detected at 30" to the northeast of the star, coinciding with an enhancement in the density of the nebula. From the analysis of the observed X-ray spectrum of the source and our theoretical emission model, we confirm that the X-ray emission is produced mainly by inverse Compton upscattering of infrared photons from dust in the shock front.Comment: Accepted for publication in the Astrophysical Journal with number ApJ, 757, L6. Four figure

A Model of DC-DC Converter with Switched-Capacitor Structure for Electric Vehicle Applications

In this paper, a DC-DC converter with an innovative topology for automotive applications is proposed. The goal of the presented power converter is the electrical storage system management of an electric vehicle (EV). The presented converter is specifically compliant with a 400 V battery, which represents the high-voltage primary source of the system. This topology is also able to act as a bidirectional power converter, so that in this case, the output section is an active stage, which is able to provide power as, for example, in the case of a low-voltage battery or a supercapacitor. The proposed topology can behave either in step-down or in step-up mode, presenting in both cases a high gain between the input and output voltage. Simulation results concerning the proposed converter, demonstrating the early feasibility of the system, were obtained in a PowerSIM environment and are described in this paper

Do personality traits and self-regulatory processes affect decision-making tendencies?

Objective: This research attempted to clarify the role played by personality traits and self-regulated motivation in affecting decision-making tendencies. Method: Study 1 (n = 209) examined whether the Big Five personality traits predict minimising, maximising, and satisficing tendencies; Study 2 (n = 460) tested the mediating role of self-regulatory orientations in the relationship between personality traits and decision-making tendencies by performing structural equation modelling with latent variables. Results: Conscientiousness emerged as the strongest positive predictor of maximising, whereas openness to experience, conscientiousness, and agreeableness emerged as negative predictors of satisficing. As for the mediational model, both locomotion and assessment played a role in mediating the relationships between the personality traits and decision-making tendencies. Conclusions: This research provided interesting insights into the underlying motivations and strategies that lead individuals to maximise, satisfice, or minimise

Genotyping of Sex Hormone-Related Pathways in Benign and Malignant Human Prostate Tissues: Data of a Preliminary Study

Prostate cancer (PCa) is a major health issue in Westernized countries, representing a common cause of morbidity and mortality in the elderly male population. Endogenous sex steroids, along with environmental factors (notably diet) and host immune and inflammatory responses, are likely to cooperate in the pathogenesis of the disease. Based on the assumption that a complex endocrine–inflammatory-immune interaction is primarily implicated in human PCa, we have investigated the interplay between sex steroids and inflammation in development and growth of human PCa. To this end, we have assessed nine functional single nucleotide polymorphisms (SNP)s of five genes involved in sex hormone-related pathways in both hyperplastic and malignant human prostate tissues, as well as in matched controls and in a ‘‘supercontrol’’ group composed of male Sicilian centenarians. In particular, the following genes were investigated: AR-OMIM313700, SRD5A2-NM-000348, CYP19-NM-031226, ERS1-NM-001122742, ERS2-NM-001040276. A significant association with prostate cancer was found in seven out of the nine SNPs considered. Although this is a preliminary study and larger investigations are needed to confirm the role of these genes in PCa development and/or progression, our data might provide an experimental basis to develop additional or alternative strategies for prevention and treatment of PCa