<p>Thin-film composite nanofiltration membrane with unprecedented stability in strong acid for highly selective dye/NaCl separation</p>

Designing and preparing nanofiltration (NF) membrane with distinguished property of acidic tolerance is attractive for handling acidic saline wastewater. In this work, we used a new monomer of 2,2-bis(3-amino-4-hydroxyphenyl)-hexafluoro-propane (bisAPAF) to prepare NF membrane by interfacial polymerization for removing dyes from acidic saline solution. Interestingly, the resulted NF membrane derived from bisAPAF and 1,3,5-trimesyol chloride (TMC) exhibits an exceptional structure stability under strong acid condition. Specifically, after exposed to H2SO4 aqueous solution with concentration of 20% (w/v) for 720 h, the NF maintains a Na2SO4 rejection of ~87%, showing little change as compared with the membrane without acidic treatment. In addition, the membrane shows a high selectivity for differentiating Direct Red 23/NaCl or Congo Red/NaCl in the pH range of 2-9, the rejection of dyes maintains at higher than 98% while the NaCl rejection is lower that ~10%. The outstanding acid tolerance property of NF membrane makes it a great promise candidate for acid wastewater remediation

<p>Thin-film composite nanofiltration membrane with unprecedented stability in strong acid for highly selective dye/NaCl separation</p>

Designing and preparing nanofiltration (NF) membrane with distinguished property of acidic tolerance is attractive for handling acidic saline wastewater. In this work, we used a new monomer of 2,2-bis(3-amino-4-hydroxyphenyl)-hexafluoro-propane (bisAPAF) to prepare NF membrane by interfacial polymerization for removing dyes from acidic saline solution. Interestingly, the resulted NF membrane derived from bisAPAF and 1,3,5-trimesyol chloride (TMC) exhibits an exceptional structure stability under strong acid condition. Specifically, after exposed to H2SO4 aqueous solution with concentration of 20% (w/v) for 720 h, the NF maintains a Na2SO4 rejection of ~87%, showing little change as compared with the membrane without acidic treatment. In addition, the membrane shows a high selectivity for differentiating Direct Red 23/NaCl or Congo Red/NaCl in the pH range of 2-9, the rejection of dyes maintains at higher than 98% while the NaCl rejection is lower that ~10%. The outstanding acid tolerance property of NF membrane makes it a great promise candidate for acid wastewater remediation

Elevated expression of TUBA1C in breast cancer predicts poor prognosis.

α1C-tubulin (TUBA1C) is a member of the α-tubulin family and has served as a potential biomarker in a variety of cancers in many studies. In this study, the gene expression profile of TUBA1C in The Cancer Genome Atlas (TCGA) was extracted for analysis, and the prognostic value of TUBA1C in breast cancer was comprehensively evaluated. The Wilcoxon signed-rank test, Kruskal-Wallis test, and logistic regression analysis were performed to confirm the correlations between TUBA1C expression and the clinical characteristics of breast cancer patients. The effect of TUBA1C expression on the survival of breast cancer patients was assessed by Kaplan-Meier curve, Cox regression analysis, and the Kaplan-Meier plotter (an online database). The TCGA data set was used for the Gene Set Enrichment Analysis (GSEA). The results confirmed that high TUBA1C expression in breast cancer was closely correlated with survival time, survival status, and tumor size. In addition, elevated TUBA1C expression can predict poor overall survival (OS), recurrence-free survival (RFS), and distant metastasis-free survival (DMFS). Univariate and multivariate analyses (Cox regression analyses) confirmed that TUBA1C was an independent prognostic factor for the OS of breast cancer patients. The GSEA identified that the high TUBA1C expression phenotype was differentially enriched in cell cycle, basal transcription factor, P53 signaling pathway, pathways in cancer, TOLL-like receptor signaling pathway, and NOD-like receptor signaling pathway. In summary, high messenger RNA (mRNA) expression of TUBA1C is an independent risk factor for poor prognosis of breast cancer

MOESM1 of Bioinformatics identification of potentially involved microRNAs in Tibetan with gastric cancer based on microRNA profiling

Additional file 1: Table S1. The significant KEGG and GO_BP terms of differentially expressed microRNAs. KEGG, Kyoto Encyclopedia of Genes and Genomes; GO Gene Ontology; BP, biological processes