Investigating Effects of Perceived Technology-enhanced Environment on Self-regulated Learning: Beyond P-values

This study examined the effects of a technology-enhanced intervention on the self-regulation of 262 eighth-grade students, employing information and communication technology (ICT) and web-based self-assessment tools set against science learning. The data were analyzed using both maximum likelihood and Bayesian structural equation modeling to unravel the intricate relationships between self-regulation, self-efficacy, perceptions of ICT, and self-assessment tools. Our research findings underscored the direct and indirect impacts of self-efficacy, perceived ease of use, and perceived use of technology on self-regulation. The results revealed the predictive power of self-assessment tools in determining self-regulation outcomes, underlining the potential of technology-enhanced self-regulated learning environments. The study posited the necessity to transcend mere technology incorporation and to emphasize the inclusion of monitoring strategies explicitly designed to augment self-regulation. Interestingly, self-efficacy appeared to indirectly influence self-regulation outcomes through perceived the use of technology rather than direct influence. Analytically, this research indicated that Bayesian estimation could offer a more comprehensive insight into structural equation modeling by more accurately assessing our estimates' uncertainty. This research substantially contributes to comprehending the influence of technology-enhanced environments on students' self-regulated learning, stressing the importance of constructing practical tools explicitly designed to cultivate self-regulation

Efficacy of Metformin for Benign Thyroid Nodules in Subjects With Insulin Resistance: A Systematic Review and Meta-Analysis

Background: To evaluate the effect of metformin therapy on decreasing benign thyroid nodule volume in subjects with insulin resistance (IR).Method: Randomized controlled trials (RCTs) and self-controlled trials for the meta-analysis published, before January 31, 2018 were selected from the PubMed, Cochrane Library, Embase, Web of Science, Chinese Biomedical Literature Database, National Knowledge Infrastructure, WANFANG and VIP Database. Pooled standard mean difference with 95% confidence interval was estimated by fixed- or random-effects model depending on heterogeneity. The risk of bias using the Cochrane Collaboration's tool was used to assess the quality of the RCTs contained. The quality of self-controlled studies was evaluated using the Methodological index for non-randomized studies (MINORS) method.Results: 7 studies (3 RCTs and 4 prospective self-controlled studies) with 240 patients were considered to be appropriate for the meta-analysis. The results of the meta-analysis indicated that the volume of thyroid nodule decreased significantly after metformin therapy (SMD −0.62, 95% CI −0.98 ~ −0.27). 6 studies reported the changes of the level of TSH. TSH levels decreased significantly after metformin therapy (SMD −0.27, 95% CI −0.47 ~ −0.07). The pooled data indicated an increase in FT3 level, and an unchanged FT4 level after metformin therapy (FT3, SMD 0.25, 95% CI 0.05 ~ 0.45; FT4, SMD −0.07, 95% CI −0.27 ~ 0.13). HOMA-IR levels decreased significantly after metformin therapy based on the pooled results of 3 RCTs and 3 prospective self-controlled studies (SMD −1.08, 95% CI −1.69 ~ −0.47).Conclusion: The meta-analysis demonstrated that metformin was safe and useful in shrinking benign thyroid nodules volume, improving thyroid function and IR. A large number of high-quality prospective studies still need to be carried out

Development of Bionic Air Cooler Used in High Temperature Coal Mine

In high temperature coal mine, the surface air cooler heat exchange efficiency decreases greatly because of high humidity and dust. In order to improve the heat exchange efficiency, the surface of the air cooler needs to be designed to reduce the dust adhesion, and improve the heat exchange efficiency. Based on the self-cleaning effect of lotus leaf, the surface of air cooler is designed and fin and tube are processed into the constructure of lotus leaf surface. With Ansys, the cooling effect of air cooler is simulated, and the experiment is done to test the heat exchange effect of the common air cooler and bionic air cooler in lab. By analysis, it can be concluded that the surface of bionic air cooler has the function of self-cleaning, and the structure can increase the heat exchange efficiency, which is higher above 30% than that of common air cooler. Key words: High temperature coal mine; Air cooler; Self-cleaning; Heat exchange efficienc

運用意識提升英語文法教學於國小外語：文法學習之效益研究

This study investigated the effects of consciousness-raising grammar teaching on EFL 6th graders’ learning of the English future tense as well as the participants’ opinions about consciousness-raising grammar teaching activities. Forty 6th graders, 20 in the high-level group and 20 in the low-level group, participated in the study for 8 weeks, twice a week, receiving consciousness-raising grammar teaching with the same activities. Pre-test and post-test were administered before and after the instruction. A questionnaire concerning consciousness-raising grammar teaching was distributed to gain the participants’ views about the activities. Paired sample t test and independent sample t test were used for analysis. The results showed that both high- and low-achievers’ performance in the posttest as compared to that in the pretest reached statistical significance. The low-achievers made even more progress than high-achievers; nevertheless, no claim can be made that conscious-raising grammar tasks are more effective for the performance of the low-achievers than the high achievers. Moreover, the participants had positive opinions about consciousness-raising tasks. The findings are in line with the previous studies (Ellis & Fotos, 1991; Fotos, 1993; Hu, 2008; Wang, 2008; Yip, 1994) concering the effecs of consciousness-raising activities.本研究探究意識提升文法教學對臺灣小六生英語未來式句型的學習成效。研究問題為：一，意識提升文法教學對高、低分組學生何者的學習成效較佳？二，研究對象對意識提升文法教學活動之看法為何？ 研究者對北市公立國小62位小六生施以劍橋兒童英語測驗，將分數在前、後各33%者，選為高分組及低分組，各20人。進行八週，每週兩次意識提升文法教學。以前、後測檢驗其對目標句型的熟悉程度。實驗教學後，以問卷調查研究對象對教學活動看法。 結果顯示，各組前、後測成績比較皆達顯著差異，且低分組進步幅度明顯多於高分組，但無法斷言意識提升文法教學活動對低分組有較佳成效。研究對象肯定意識提升文法教學活動。據此，研究者提出教學及研究建議

A novel FBN2 mutation in a Chinese family with congenital contractural arachnodactyly

AbstractCongenital contractural arachnodactyly (CCA, OMIM: 121050) is an autosomal dominant condition that shares skeletal features with Marfan syndrome (MFS, OMIM: 154700), including contractures, arachnodactyly, dolichostenomelia, scoliosis, crumpled ears and pectus deformities but excluding the ocular and cardiovascular complications that characterize MFS. These two similar syndromes result from mutations in two genes belonging to the fibrillin family, FBN1 and FBN2, respectively. We successfully identified a novel FBN2 mutation (C1406R) in a Chinese family with CCA for over five generations. This mutation was detected in the patients of this family but not in the seven unaffected family members or 100 normal individuals. SIFT and PolyPhen analyses suggested that the mutation was pathogenic. We identified a missense mutation in the calcium binding-epidermal growth factor (cbEGF)-like domain. Our study extends the mutation spectrum of CCA and confirms a relationship between mutations in the FBN2 gene and the clinical findings of CCA

Associations between impulsivity, aggression, and suicide in Chinese college students

BACKGROUND: Although there are accumulating data regarding the epidemiology of suicide in China, there are meager data on suicidal ideation and attempts among college students. Interestingly, elevated impulsivity is thought to facilitate the transition from suicidal thoughts to suicidal behavior. Therefore, the objective of this research was to identify the associations between suicide and the personality factors of impulsivity and aggression. METHODS: This study’s sampling method employed stratified random cluster sampling. A multi-stage stratified sampling procedure was used to select participants (n = 5,245). We conducted structured interviews regarding a range of socio-demographic characteristics and suicidal morbidity. The Patient Health Questionnaire depression module (PHQ-9) was used to acquire the information about thoughts of being better off dead or hurting themselves in some ways during the past two weeks. The impulsivity symptoms in this study were assessed with the BIS-11-CH (i.e., the Chinese version of the BIS-11), and the Aggressive symptoms were assessed with the BAQ. The statistical package for social science (SPSS) v.13.0 program (SPSS Inc., Chicago, IL, USA) was used for statistical analysis. Socio-demographic variables such as ethnic and gender were compared between groups, through the use of χ(2) tests. The nonparametric test (k Independent Sample test, Kruskal-Wallis H) was performed to determine differences between the personality factors of impulsivity and aggression and suicide. RESULTS: In total, 9.1% (n = 479) of the 5,245 students reported they have ever thought about committing suicide; and 1% (n = 51) reported a history of attempted suicide (attempters). The analyses detected significant differences in scores on cognitive impulsivity (p < 0.01), when comparing individuals who only had suicidal ideation and individuals who had attempted suicide. Moreover, significant differences were found between ideators only and attempters on scores of self-oriented attack (p < .001). CONCLUSIONS: Suicidal ideation is prevalent among Chinese university students. Students with high aggression scores were more susceptible to committing suicide. Scores on self-oriented attack and cognitive impulsivity may be important factors for differentially predicting suicide ideation and suicide attempts

MicroRNAs in spermatogenesis dysfunction and male infertility: clinical phenotypes, mechanisms and potential diagnostic biomarkers

Infertility affects approximately 10–15% of couples worldwide who are attempting to conceive, with male infertility accounting for 50% of infertility cases. Male infertility is related to various factors such as hormone imbalance, urogenital diseases, environmental factors, and genetic factors. Owing to its relationship with genetic factors, male infertility cannot be diagnosed through routine examination in most cases, and is clinically called ‘idiopathic male infertility.’ Recent studies have provided evidence that microRNAs (miRNAs) are expressed in a cell-or stage-specific manner during spermatogenesis. This review focuses on the role of miRNAs in male infertility and spermatogenesis. Data were collected from published studies that investigated the effects of miRNAs on spermatogenesis, sperm quality and quantity, fertilization, embryo development, and assisted reproductive technology (ART) outcomes. Based on the findings of these studies, we summarize the targets of miRNAs and the resulting functional effects that occur due to changes in miRNA expression at various stages of spermatogenesis, including undifferentiated and differentiating spermatogonia, spermatocytes, spermatids, and Sertoli cells (SCs). In addition, we discuss potential markers for diagnosing male infertility and predicting the varicocele grade, surgical outcomes, ART outcomes, and sperm retrieval rates in patients with non-obstructive azoospermia (NOA)