697,232 research outputs found

    Cultural analysis of hero frames in American and North Korean media: focusing on tragedy and glorification

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    Title from PDF of title page (University of Missouri--Columbia, viewed on September 11, 2013).The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.Thesis advisor: Dr. Sandra DavidsonIncludes bibliographical references.M.A. University of Missouri--Columbia 2013.Dissertations, Academic -- University of Missouri--Columbia -- Journalism."May 2013"Both the U.S. media and The Rodong Sinmun, the state news website of North Korea, used hero frames to describe each other. The hero frame of the United States described itself as a hero, North Korea and Middle Eastern countries as villains, and the people of those countries and sometimes the United States as victims. Meanwhile, The Rodong Sinmun of North Korea used "hero" and "heroic" without a refined symbol system. In The Rodong Sinmun, Kim Il-Sung and Kim Jong-Il were the utmost heroes in that they enabled the heroic working class of North Korea to realize their historic importance and led North Korean soldiers in their success against imperialists. The hero frame used to describe Kim Il-Sung included metaphors such as an affectionate father, the sun, and a tiger. The hero frame for Kim Jong-Il used metaphors such as a mother, the sunshine, and a crane. Kim Il-Sung and Kim Jong-Il were perceived to be optimistic heroes who were not allowed in Korean traditional culture, as featured as the emotion of "han" and in the fable "Baby Commander.

    Recital: Korea\u27s Kim Trio: Won-Mi Kim, Piano; Won-Joo Kim, Violin; Won-Hee Kim, Cello; September 3, 1974

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    Centennial East Recital HallTuesday EveningSeptember 3, 19748:15 p.m

    What is the relationship between environmental experiences and New Ecological Paradigm scale of Purdue University undergraduate students?

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    Kim, Mi Yen. Master of Science in Education., Purdue University, December 2016. What is the Relationship Between Environmental Experiences and New Ecological Paradigm Scale of Purdue University Undergraduate Students? Major Professor: Daniel Shepardson

    DETERMINANTS OF ANTI-RETROVIRAL THERAPY DRUG-RELATED TOXICITIES IN HIV POSITIVE PATIENTS

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    Antiretroviral therapy (ART) drugs have increasingly been shown to contribute significantly to the morbidity of HIV positive patients exposed to them. This is more so with increasing survival of HIV patients since the introduction of ART. Individual ART drugs have been associated with specific organ related toxicities and clinical toxicity syndromes, such as Tenofovir disoproxil fumarate (TDF) association with risk of kidney injury. The pattern, pathogenesis, as well as key genetic and non-genetic determinants of some these clinical ART drug-related toxicity syndromes remains uncertain. This thesis sets out to investigate the pattern/clinical/laboratory phenotype of ART drug related kidney toxicity, including the role of emerging biomarkers that define and most accurately diagnose these toxicity syndromes. I, and my co-reviewer (Dr Sudeep Pushpakom, University of Liverpool) then systematically reviewed, and carried out a metanalysis of current evidence with regards to the reported genetic association between TDF exposure, and risk of kidney related toxicity. I further explored a population cohort (MHRA) to ascertain the pattern/clinical phenotype of kidney injury following exposure to TDF in these cohorts of patients, and determine any discernible variation as it relates to what has been reported from clinical trial cohorts. Additionally, I examined the association between single nucleotide polymorphisms (SNPs) of genes encoding protein transporters involved in the bio-disposition of TDF in HIV positive patients, with kidney injury following exposure to ART drugs. Specifically, in an attempt to explore the pattern of kidney injury in HIV patients exposed to TDF in observational databases, I reviewed 407 yellow card records of HIV positive patients on TDF who developed kidney injury and had them reported to MHRA. One hundred and six (106) of these satisfied criteria for TDF related kidney injury, of which 53 (50%) had features of kidney tubular dysfunction (KTD), 35 (33%) were found to have features of glomerular dysfunction, and 18 (17%) had Fanconi syndrome. The median TDF exposure was 316 days (IQR 120-740). The incidence of hospitalisation for TDF kidney adverse effects was high, particularly amongst patients with features of Fanconi syndrome. To define the clinical phenotype (including surrogate markers) of ART drug related kidney injury, I recruited and investigated the diagnostic utility of KIM-1/Cr (corrected for urinary creatinine excretion) in a 114 cross-sectional cohort of HIV positive patients (104 “on” ART, and 10 “off” ART drugs). HIV positive patients both “on” and “off” ART drugs had a higher baseline median (≥4.17ng/mg), upper quartile (≥8.6ng/mg), and urinary KIM-1/Cr levels compared to either non-HIV positive normal volunteers (0.39 ng/mg), or those with acute kidney injury in the general population (0.57 ng/mg). By ROC analysis, KIM-1/Cr (ng/mg) had a higher AUC (0.67) compared to either serum creatinine (0.64) or eGFR (0.31) in diagnosing patients with kidney injury. When median KIM-1/Cr (≥4.17ng/mg) was utilised as a marker of kidney injury, TDF exposure (per year increase) was significantly associated with risk of kidney injury in multivariate analyses (Odds ratio 1.4, CI 1.02-1.82, P = 0.034). In a candidate gene based-based approach, I subsequently investigated the strength of association between the ABCC2 and ABCC10 sub-family genetic polymorphisms, and risk of kidney injury in HIV positive patients exposed to TDF. Patients with KTD had higher current CD4 cell counts, lower eGFR, and were less likely to possess the genotype CC at position 24 of the ABBC2 (MRP2, rs717620) gene. In multivariate analysis, genotype CC at position 24 of the ABBC2 gene (odds ratio =0.05, 95% confidence interval = 0.003-0.7, P = 0.027) was significantly associated with reduced risk of KTD. These findings support the observation that ART dugs are a leading cause of organ specific morbidity including TDF related kidney injury. Furthermore, we have demonstrated higher thresholds of low molecular weight proteinuria (including RBPCR and KIM-1/Cr) following TDF exposure, in HIV positive patients with normal kidney function (normal eGFR). Further work is required in prospective patient populations to validate some of the findings in our study including the potential diagnostic utility of low molecular weight proteinuria (KIM-1 and RBP) in these cohorts of patients. Additionally, there will be need to explore the clinical significance of possession of the ABCC2 24CC (rs717620) and ABCC10 SNP’s in an appropriately defined patient populatio

    Quantile regression with varying coefficients

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    Quantile regression provides a framework for modeling statistical quantities of interest other than the conditional mean. The regression methodology is well developed for linear models, but less so for nonparametric models. We consider conditional quantiles with varying coefficients and propose a methodology for their estimation and assessment using polynomial splines. The proposed estimators are easy to compute via standard quantile regression algorithms and a stepwise knot selection algorithm. The proposed Rao-score-type test that assesses the model against a linear model is also easy to implement. We provide asymptotic results on the convergence of the estimators and the null distribution of the test statistic. Empirical results are also provided, including an application of the methodology to forced expiratory volume (FEV) data.Comment: Published at http://dx.doi.org/10.1214/009053606000000966 in the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org

    The Anomalous Behavior of Solid 4^{4}He in Porous Vycor Glass

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    The low temperature properties of solid 4^4He contained in porous Vycor glass have been investigated utilizing a two-mode compound torsional oscillator. At low temperatures, we find period shift signals for the solid similar to those reported by Kim and Chan \cite{ref1}, which were taken at the time as evidence for a supersolid helium phase. The supersolid is expected to have properties analogous to those of a conventional superfluid, where the superfluid behavior is independent of frequency and the ratio of the superfluid signals observed at two different mode periods will depend only on the ratio of the sensitivities of the mode periods to mass-loading. In the case of helium studies in Vycor, one can compare the period shift signals seen for a conventional superfluid film with signals obtained for a supersolid within the same Vycor sample. We find, contrary to our own expectations, that the signals observed for the solid display a marked period dependence not seen in the case of the superfluid film. This surprising result suggests that the low temperature response of solid 4^4He in a Vycor is more complex than previously assumed and cannot be thought of as a simple superfluid.Comment: 4 pages, 5 figure

    Student Recital: Won-Mi Kim, Piano; April 2, 1976

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    Recital HallFriday EveningApril 2, 19768:15 p.m
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