The University of Florida’s Scientific Thinking and Educational Partnership Program: An Approach for Genetics Outreach

In an effort to compete for multimillion-dollar grants that require researchers to translate their findings for the general public in the form of outreach programs, the University of Florida developed the Scientific Thinking and Educational Partnership (STEP) program. This article describes the evolution of the STEP program, from the creation of a model outreach program called ufgenetics.com—a Web site geared toward media professionals and middle school and high school teachers—to the testing, evaluation, and promotion of that project. The STEP program has garnered over $1 million in grants in just 2 years of existence

Introduction to geochemistry of metalliferous black shales

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29848/1/0000195.pd

Concert recording 2018-11-02

[Track 1]. My house from Matilda / Tim Minchin -- [Track 2]. Everybody loves Louis from Sunday in the park with George / Stephen Sondheim -- [Track 3]. Per la gloria d\u27adorarvi / Giovanni Battista Bononcini -- [Track 4]. The vagabond / Ralph Vaughan Williams -- [Track 5]. Se tu m\u27ami / Alessandro Parisotti -- [Track 6]. Die Hölle Rache kocht from The magic flute / Wolfgang Amadeus Mozart -- [Track 7]. Dans un boire solitaire / Wolfgang Amadeus Mozart -- [Track 8]. Love\u27s philosophy / Roger Quilter -- [Track 9]. Comme raggio di sol / Antonio Caldara -- [Track 10]. The vagabond / Ralph Vaughan Williams -- [Track 11]. Sognai / Francesco Schira -- [Track 12]. Fair Robin I love from Tartuffe / Kirke Mechem -- [Track 13]. Sonntag, op. 47, no. 3 / Johannes Brahms -- [Track 14]. O del mio amato ben / Stefano Donaudy -- [Track 15]. Spring / Dominick Argento -- [Track 16]. Gott im Frühling, D. 448 / Franz Schubert -- [Track 17]. Vaga luna, che inargent / Vincenzo Bellini -- [Track 18]. The Salley gardens / Benjamin Britten -- [Track 19]. Three browning songs, op. 44. I. The year\u27s at the spring II. Ah, love, but a day III. I send my heart up to thee / Amy Beach -- [Track 20]. From Dichterliebe, op. 48. 6. Im Rhein, im heiligin Strome 7. Ich grolle nicht 8. Und wüssten\u27s die Blumen, die kleinen 9. Das ist ein Flöten und Geigen / Robert Schumann -- [Track 21]. Thy hand, Belinda from Dido and Aeneas / Henry Purcell -- [Track 22]. Cowboy songs. I. Bucking bronco II. Lift me into heaven slowly III. Billy the kid / Libby Larsen

Population Health Solutions for Assessing Cognitive Impairment in Geriatric Patients.

In December 2017, the National Academy of Neuropsychology convened an interorganizational Summit on Population Health Solutions for Assessing Cognitive Impairment in Geriatric Patients in Denver, Colorado. The Summit brought together representatives of a broad range of stakeholders invested in the care of older adults to focus on the topic of cognitive health and aging. Summit participants specifically examined questions of who should be screened for cognitive impairment and how they should be screened in medical settings. This is important in the context of an acute illness given that the presence of cognitive impairment can have significant implications for care and for the management of concomitant diseases as well as pose a major risk factor for dementia. Participants arrived at general principles to guide future screening approaches in medical populations and identified knowledge gaps to direct future research. Key learning points of the summit included: recognizing the importance of educating patients and healthcare providers about the value of assessing current and baseline cognition;emphasizing that any screening tool must be appropriately normalized and validated in the population in which it is used to obtain accurate information, including considerations of language, cultural factors, and education; andrecognizing the great potential, with appropriate caveats, of electronic health records to augment cognitive screening and tracking of changes in cognitive health over time

In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra

Premature cervical remodeling is a critical precursor of spontaneous preterm birth, and the remodeling process is characterized by an increase in tissue hydration. Nevertheless, current clinical measurements of cervical remodeling are subjective and detect only late events, such as cervical effacement and dilation. Here, we present a photoacoustic endoscope that can quantify tissue hydration by measuring near-infrared cervical spectra. We quantify the water contents of tissue-mimicking hydrogel phantoms as an analog of cervical connective tissue. Applying this method to pregnant women in vivo, we observed an increase in the water content of the cervix throughout pregnancy. The application of this technique in maternal healthcare may advance our understanding of cervical remodeling and provide a sensitive method for predicting preterm birth

Joint Statement on Pediatric Education at Schools of Pharmacy

Providing health care for children is a unique specialty, and pediatric patients represent approximately 25% of the population. Education of pharmacy students on patients across the lifespan is required by current Accreditation Council for Pharmacy Education standards and outcomes; thus, it is essential that pharmacy students gain a proficiency in caring for children. A collaborative panel of pediatric faculty members from schools and colleges of pharmacy was established to review the current literature regarding pediatric education in Doctor of Pharmacy curricula and establish updated recommendations for the provision of pediatric pharmacy education. This statement outlines five recommendations supporting inclusion of pediatric content and skills in Doctor of Pharmacy curricula

Selective Inhibition of p300 HAT Blocks Cell Cycle Progression, Induces Cellular Senescence, and Inhibits the DNA Damage Response in Melanoma Cells

Epigenetic events, including covalent post-translational modifications of histones, have been demonstrated to have critical roles in tumor development and progression. The transcriptional coactivator p300/CBP possesses both histone acetyltransferase (HAT) activity and scaffolding properties that directly influence the transcriptional activation of targeted genes. We have used a potent and specific inhibitor of p300/CBP HAT activity, C646, in order to evaluate the functional contributions of p300/CBP HAT to tumor development and progression. Here we report that C646 inhibits the growth of human melanoma and other tumor cells and promotes cellular senescence. Global assessment of the p300 HAT transcriptome in human melanoma identified functional roles in promoting cell cycle progression, chromatin assembly, and activation of DNA repair pathways through direct transcriptional regulatory mechanisms. In addition, C646 is shown to promote sensitivity to DNA damaging agents, leading to the enhanced apoptosis of melanoma cells after combination treatment with cisplatin. Together, our data suggest that p300 HAT activity mediates critical growth regulatory pathways in tumor cells and may serve as a potential therapeutic target for melanoma and other malignancies by promoting cellular responses to DNA damaging agents that are currently ineffective against specific cancers