High temperature constitutive and crack initiation modeling of coated single crystal superalloys

The purpose of this program is to develop life prediction models for anisotropic materials used in gas turbine airfoils. In the base portion of the program, two coated single crystal alloys are being tested. They are PWA 286 overlay coated and PWA 273 aluminide coated PWA 1480 and PWA 286 overlay coated Alloy 185. Viscoplastic constitutive models for these materials are also being developed to predict the cyclic stress-strain histories required for life prediction of the lab specimens and actual airfoil designs

Оценка гидрогеодинамического влияния режима эксплуатации скважин на основе статистических функций

Исследовано воздействие работы эксплуатационных скважин полигона захоронения промышленных отходов Сибирского химического комбината на колебание напоров в наблюдательных скважинах и выделение частотных составляющих техногенного и природного колебаний в спектре. Показана возможность использования функции взаимной корреляции и Фурье-анализа для оценки гидрогеодинамического влияния режима работы эксплуатационных скважин

Extraction of auxiliary data from AVIRIS distribution tape for spectral, radiometric, and geometric quality assessment

Remotely sensed data are affected by system (sensor and platform), and scene related effects. For quantitative investigations the spectral, radiometric characteristics of the system and scene have to be known. The relevant effects and their possible influence on an image have to be specifically determined for every remote sensing system and adequate description parameters need to be updated and reported on a regular basis as they are carried out, e.g., for the AVIRIS system. It is evident that the strength of the influence of similar effects in very dependent on the accessibility of auxiliary information about such sensor systems. Degradation in a spaceborne system can normally be just reported and cannot be corrected. In contrast, an airborne sensor can be evaluated, maintained and improved periodically. Such maintenance efforts are particularly important because airborne systems are exposed to extreme and changing environments. These include tens of takeoffs and landing each year as well as extreme changes in temperature and humidity on the tarmac and in flight. For the AVIRIS system there are environmental stresses such as changes in temperature, air pressure, humidity, vibration of the platform or scene-related reasons like atmospheric conditions, and topography. The information contained in the auxiliary files included with the AVIRIS data can be used to assess these effects and compensate for them. In addition the spectral, radiometer and geometric calibration data contained in the auxiliary file are required for quantitative analysis of the data. The paper describes tools to access the auxiliary information that characterizes the AVIRIS system. These tools allow the examination of parameters that may impact the quality of the measured AVIRIS image. An example of the use of this auxiliary data was carried out with regard to a parametric geocoding approach. Emphasis is placed on the reported auxiliary information that describes the geometric character of the AVIRIS data in 1991. Results are presented using data from the AVIRIS flight #910705, run 6 and 7 of the NASA MAC Europe 1991 campaign in a test site in Central Switzerland

Characterizing Scales of Genetic Recombination and Antibiotic Resistance in Pathogenic Bacteria Using Topological Data Analysis

Pathogenic bacteria present a large disease burden on human health. Control of these pathogens is hampered by rampant lateral gene transfer, whereby pathogenic strains may acquire genes conferring resistance to common antibiotics. Here we introduce tools from topological data analysis to characterize the frequency and scale of lateral gene transfer in bacteria, focusing on a set of pathogens of significant public health relevance. As a case study, we examine the spread of antibiotic resistance in Staphylococcus aureus. Finally, we consider the possible role of the human microbiome as a reservoir for antibiotic resistance genes.Comment: 12 pages, 6 figures. To appear in AMT 2014 Special Session on Advanced Methods of Interactive Data Mining for Personalized Medicin

Whole-exome sequencing prioritizes candidate genes for hereditary cataract in the Emory mouse mutant

The Emory cataract (Em) mouse mutant has long been proposed as an animal model for age-related or senile cataract in humans-a leading cause of visual impairment. However, the genetic defect(s) underlying the autosomal dominant Em phenotype remains elusive. Here, we confirmed development of the cataract phenotype in commercially available Em/J mice [but not ancestral Carworth Farms White (CFW) mice] at 6-8 months of age and undertook whole-exome sequencing of candidate genes for Em. Analysis of coding and splice-site variants did not identify any disease-causing/associated mutations in over 450 genes known to underlie inherited and age-related forms of cataract and other lens disorders in humans and mice, including genes for lens crystallins, membrane/cytoskeleton proteins, DNA/RNA-binding proteins, and those associated with syndromic/systemic forms of cataract. However, we identified three cataract/lens-associated genes each with one novel homozygous variant including predicted missense substitutions in Prx (p.R167C) and Adamts10 (p.P761L) and a disruptive in-frame deletion variant (predicted missense) in Abhd12 (p.L30_A32delinsS) that were absent in CFW and over 35 other mouse strains. In silico analysis predicted that the missense substitutions in Prx and Adamts10 were borderline neutral/damaging and neutral, respectively, at the protein function level, whereas, that in Abhd12 was functionally damaging. Both the human counterparts of Adamts10 and Abhd12 are clinically associated with syndromic forms of cataract known as Weil-Marchesani syndrome 1 and polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract syndrome, respectively. Overall, while we cannot exclude Prx and Adamts10, our data suggest that Abhd12 is a promising candidate gene for cataract in the Em/J mouse