94 research outputs found

    The Nature of 3, 4-Methylenedioxymethamphetamine (MDMA)-Induced Serotonergic Dysfunction: Evidence for and Against the Neurodegeneration Hypothesis

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    High doses of the recreational drug 3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) have been well-documented to reduce the expression of serotonergic markers in several forebrain regions of rats and nonhuman primates. Neuroimaging studies further suggest that at least one of these markers, the plasma membrane serotonin transporter (SERT), may also be reduced in heavy Ecstasy users. Such effects, particularly when observed in experimental animal models, have generally been interpreted as reflecting a loss of serotonergic fibers and terminals following MDMA exposure. This view has been challenged, however, based on the finding that MDMA usually does not elicit glial cell reactions known to occur in response to central nervous system (CNS) damage. The aim of this review is to address both sides of the MDMA-neurotoxicity controversy, including recent findings from our laboratory regarding the potential of MDMA to induce serotonergic damage in a rat binge model. Our data add to the growing literature implicating neuroregulatory mechanisms underlying MDMA-induced serotonergic dysfunction and questioning the need to invoke a degenerative response to explain such dysfunction

    Stressing the Hormone: Biological and Psychosocial Factors associated with Chronic Stress

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    Chronic stress has been associated with a constellation of deleterious psychological and physical health outcomes. We collected cortisol from hair (CORT) to assess chronic stress retrospectively for 3 months’ time (3cms). Over two studies from the UMass Boston campus and the local community, we recruited in t1: 134 adults (ages 18-67; M = 29.49, SD = 12.48) and t2: 145 adults (ages18-30, M = 22.56, SD = 3.54) to participate on two studies assessing objective biological stress (via hair cortisol), subjective perceived stress (via self-reports), psychosocial factors, and health indicators. In follow-up Study 2, we also included indices of perceived discrimination, cardiovascular parameters, and affective vigilance. Results: t1: CORT levels were positively associated with Total perceived stress and one health indicator: systolic blood pressure. An SES by Race interaction predicted both higher CORT and perceived stress, although higher SES did not always confer the expected benefit of higher SES: minorities in high SES had the greatest CORT, systolic blood pressure, and lowest self-rated health. Results: t2: Perceived stress measures and new measures of discrimination were negatively associated with well-being and health. Higher racial/ethnic pride was associated with better health, but also increased daily discrimination and waist-to-hip ratio. The SES by Race interaction was again associated with Total perceived stress and minorities in higher SES reported greatest Total stress. Minorities also showed the greatest vigilance. Specifically, African-Americans had the longest latencies for social devaluation words during a modified Stroop, the greatest city stress, and the greatest pride/identity for heritage group

    Objective and Subjective Stress Differences: Foreign-Born and U.S. Native Adults in Boston Communities

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    This study compares two high-risk populations: foreign- and US-born adults residing in the same Boston neighborhoods noted for high violence, low income, and greater morbidity and mortality for several chronic diseases (Health of Boston, 2010). The aims of the study are to improve community engagement and to identify stress-related differences between foreign and US-born adults and the interrelations between physiological and subjective stress indices in these populations. This presentation is part of the mini-symposium titled: How Community-Academic Partnership Initiatives Can Contribute to Translational Research

    Relationships between affiliative social behavior and hair cortisol concentrations in semi-free ranging rhesus monkeys

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    Sociality is a fundamental aspect of human behavior and health. One benefit of affiliative social relationships is reduced short-term levels of glucocorticoids (GCs), which are indicative of physiological stress. Less is known, however, about chronic GC production in relation to affiliative social behavior. To address this issue, we studied a semi-free ranging troop of rhesus macaques (Macaca mulatta) and collected hair samples to measure hair cortisol concentrations (HCCs), as a measure of chronic GC production, during routine biannual exams. We collected social behavior (both aggressive and affiliative) and hair samples for 32 adult female rhesus macaques over one year (Experiment 1). Our results indicated that adult females who initiated higher levels of social affiliation had significantly lower levels of HCCs. Neither the initiation nor the receipt of aggression were significantly related to HCCs in this study. In a second experiment we studied 28 mother-infant dyads for the first 90 days postpartum to examine mother-infant facial interactions (i.e. mutual gazing). We analyzed HCCs during weaning approximately one year later, which is a major transitional period. We found that infants that engaged in higher levels of mutual gazing in the first 90 days postpartum had significantly lower levels of HCCs during weaning. Finally, we studied 17 infant rhesus macaques (13 males) to examine whether social behavior (such as play) in the first five months of life correlated with infant HCCs over those months (Experiment 3). We found that infant males that engaged in more social play had significantly lower levels of HCCs. By relying on an animal model, our study shows that affiliative social traits are associated with lower long-term GC production. Future research should address the complex interactions between social behavior, chronic GC production, and mental and physical health

    Genetic evidence of Dobrava virus in Apodemus agrarius in Hungary.

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    Using nested polymerase chain reaction, we sequenced Dobrava virus (DOB) from the rodent Apodemus agrarius in Hungary. The samples we isolated group with DOB samples previously isolated from A. flavicollis. This grouping may indicate host switching

    Randomized evaluation of fibrinogen versus placebo in complex cardiovascular surgery : post hoc analysis and interpretation of phase III results

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    OBJECTIVES: In a multicentre, randomized-controlled, phase III trial in complex cardiovascular surgery (Randomized Evaluation of Fibrinogen vs Placebo in Complex Cardiovascular Surgery: REPLACE), single-dose human fibrinogen concentrate (FCH) was associated with the transfusion of increased allogeneic blood products (ABPs) versus placebo. Post hoc analyses were performed to identify possible reasons for this result. METHODS: We stratified REPLACE results by adherence to the transfusion algorithm, pretreatment fibrinogen level (2g/l) and whether patients were among the first 3 treated at their centre. RESULTS: Patients whose treatment was adherent with the transfusion algorithm [FCH, n=47 (60.3%); placebo, n=57 (77.0%); P=0.036] received smaller quantities of ABPs than those with non-adherent treatment (P2g/l and fewer patients undergoing thoracoabdominal aortic aneurysm repair. CONCLUSIONS: None of the patient stratifications provided a clear explanation for the lack of efficacy seen for FCH in the REPLACE trial versus the positive phase II outcomes. However, together, the 3 factors demonstrated trends favouring FCH. Less familiarity with the protocol and procedures and unavoidable differences in the study populations may explain the differences seen between the phase II study and REPLACE.Peer reviewe
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