Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]

To determine the efficacy and safety of risedronate in patients with knee osteoarthritis (OA), the British study of risedronate in structure and symptoms of knee OA (BRISK), a 1-year prospective, double-blind, placebo-controlled study, enrolled patients (40–80 years of age) with mild to moderate OA of the medial compartment of the knee. The primary aims were to detect differences in symptoms and function. Patients were randomized to once-daily risedronate (5 mg or 15 mg) or placebo. Radiographs were taken at baseline and 1 year for assessment of joint-space width using a standardized radiographic method with fluoroscopic positioning of the joint. Pain, function, and stiffness were assessed using the Western Ontario and McMaster Universities (WOMAC) OA index. The patient global assessment and use of walking aids were measured and bone and cartilage markers were assessed. The intention-to-treat population consisted of 284 patients. Those receiving risedronate at 15 mg showed improvement of the WOMAC index, particularly of physical function, significant improvement of the patient global assessment (P < 0.001), and decreased use of walking aids relative to patients receiving the placebo (P = 0.009). A trend towards attenuation of joint-space narrowing was observed in the group receiving 15 mg risedronate. Eight percent (n = 7) of patients receiving placebo and 4% (n = 4) of patients receiving 5 mg risedronate exhibited detectable progression of disease (joint-space width ≥ 25% or ≥ 0.75 mm) versus 1% (n = 1) of patients receiving 15 mg risedronate (P = 0.067). Risedronate (15 mg) significantly reduced markers of cartilage degradation and bone resorption. Both doses of risedronate were well tolerated. In this study, clear trends towards improvement were observed in both joint structure and symptoms in patients with primary knee OA treated with risedronate

Initial Leakage Under Pit and Fissure Sealants Assessed by Neutron Activation

An improved neutron activation method and a model system were used to study microleakage associated with three pit and fissure sealants. Both the sealant and the etching procedure were evaluated on enamel surfaces as well as in prepared model pits. Leakage was reduced to 3 to 4 μg for all three materials, and the etching process was relatively ineffective in forming an initial seal.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66699/2/10.1177_00220345740530062501.pd

Integrating process design and control: An application of optimal control to chemical processes

In this paper, the optimal design of process systems generically used in chemical industries is studied. The closely coupled nature of optimal design specification of the equipment, the determination of the optimal process parameters in steady-state, moreover, some issues of the application of optimal control is shown. The solution of the overall optimization problem including (i) optimal design of the equipment and (ii) specification of its optimal control strategy can be found relying on two different design concepts, namely, on the conventionally used sequential or, on the newly emerged simultaneous design approaches. This paper gives the theoretical background of the ideas and presents a comparative summary of the approaches. The two approaches are contrasted to each other in which the effects of the interaction of optimal process design and optimal control is highlighted. A new simultaneous optimization procedure providing economic and operability benefits over the traditional stand-alone approach is proposed. The applicability of the idea is demonstrated by means of a design study carried out for optimal design of a coaxial heat exchanger and a reactive distillation column for the synthesis of ethyl tert butyl ether (ETBE), relying on the benefits of the utilization of optimal control

Magneto-photoluminescence spectroscopy of single InAs/AlAs quantum dots

We present non-resonant, polarization-resolved magneto-photoluminescence measurements up to 12 T on single InAs/AlAs quantum dots. We observe typical g-factors between 1 and 2, very low diamagnetic shifts due to strong exciton localization and low-energy sidebands, which are attributed to the piezoelectric exciton-acoustic phonon interaction.Spanish Ministry of Education/MAT2008- 01555/NANSpanish Ministry of Education/Consolider CSD 2006-19Community of Madrid CAMS-0505-ESP-0200Spanish Ministry of Science and Innovation/Nanoinpho-QD TEC2008-06756-C03-0

The quadratic spinor Lagrangian is equivalent to the teleparallel theory

The quadratic spinor Lagrangian is shown to be equivalent to the teleparallel / tetrad representation of Einstein's theory. An important consequence is that the energy-momentum density obtained from this quadratic spinor Lagrangian is essentially the same as the ``tensor'' proposed by Moller in 1961.Comment: 10 pages, RevTe

On the effective action of confining strings

We study the low-energy effective action on confining strings (in the fundamental representation) in SU(N) gauge theories in D space-time dimensions. We write this action in terms of the physical transverse fluctuations of the string. We show that for any D, the four-derivative terms in the effective action must exactly match the ones in the Nambu-Goto action, generalizing a result of Luscher and Weisz for D=3. We then analyze the six-derivative terms, and we show that some of these terms are constrained. For D=3 this uniquely determines the effective action for closed strings to this order, while for D>3 one term is not uniquely determined by our considerations. This implies that for D=3 the energy levels of a closed string of length L agree with the Nambu-Goto result at least up to order 1/L^5. For any D we find that the partition function of a long string on a torus is unaffected by the free coefficient, so it is always equal to the Nambu-Goto partition function up to six-derivative order. For a closed string of length L, this means that for D>3 its energy can, in principle, deviate from the Nambu-Goto result at order 1/L^5, but such deviations must always cancel in the computation of the partition function. Next, we compute the effective action up to six-derivative order for the special case of confining strings in weakly-curved holographic backgrounds, at one-loop order (leading order in the curvature). Our computation is general, and applies in particular to backgrounds like the Witten background, the Maldacena-Nunez background, and the Klebanov-Strassler background. We show that this effective action obeys all of the constraints we derive, and in fact it precisely agrees with the Nambu-Goto action (the single allowed deviation does not appear).Comment: 71 pages, 7 figures. v2: added reference, minor corrections. v3: removed one term from the effective action since it is trivial. The conclusions on the corrections to energy levels are unchanged, but the claim that the holographic computation shows a deviation from Nambu-Goto was modified. v4: added reference