Data on sex differences in one-year outcomes of out-of-hospital cardiac arrest patients without ST-segment elevation

Sex differences in out-of-hospital cardiac arrest (OHCA) patients are increasingly recognized. Although it has been found that post-resuscitated women are less likely to have significant coronary artery disease (CAD) than men, data on follow-up in these patients are limited. Data for this data in brief article was obtained as a part of the randomized controlled Coronary Angiography after Cardiac Arrest without ST-segment elevation (COACT) trial. The data supplements the manuscript “Sex differences in out-of-hospital cardiac arrest patients without ST-segment elevation: A COACT trial substudy” were it was found that women were less likely to have significant CAD including chronic total occlusions, and had worse survival when CAD was present. The dataset presented in this paper describes sex differences on interventions, implantable-cardioverter defibrillator (ICD) shocks and hospitalizations due to heart failure during one-year follow-up in patients successfully resuscitated after OHCA. Data was derived through a telephone interview at one year with the patient or general practitioner. Patients in this randomized dataset reflects a homogenous study population, which can be valuable to further build on research regarding long-term sex differences and to further improve cardiac care

Transgenesis may affect farm animal welfare: a case for systematic risk assessment

This paper considers (potentially) harmful consequences of transgenesis for farm animal welfare and examines the strategy of studying health and welfare of transgenic farm animals. Evidence is discussed showing that treatments imposed in the context of farm animal transgenesis are by no means biologically neutral and may compromise animal health and welfare. Factors posing a risk for the welfare of transgenic farm animals include integration of a transgene within an endogenous gene with possible loss of host gene function (insertional mutations), inappropriate transgene expression and exposure of the host to biologically active transgene-derived proteins, and in vitro reproductive technologies employed in the process of generating transgenic farm animals that may result in an increased incidence of difficult parturition and fetal and neonatal losses and the development of unusually large or otherwise abnormal offspring (large offspring syndrome). Critical components of a scheme for evaluating welfare of transgenic farm animals are identified, related to specific characteristics of transgenic animals and to factors that may interact with the effects of transgenesis. The feasibility of an evaluation of welfare of transgenic farm animals in practice is addressed against the background of the objectives and conditions of three successive stages in a long-term transgenic program. Concrete steps with regard to breeding and testing of transgenic farm animals are presented, considering three technologies to generate transgenic founders: microinjection, electroporation and nuclear transfer, and gene targeting including gene knockout. The proposed steps allow for unbiased estimations of the essential treatment effects, including hemi- and homozygous transgene effects as well as effects of in vitro reproductive technologies. It is suggested that the implementation of appropriate breeding and testing procedures should be accompanied by the use of a comprehensive welfare protocol, specifying which parameters to monitor, at which stages of the life of a farm animal, and in how many animals. Some prerequisites and ideas for such a protocol are given. It is anticipated that systematic research into the welfare of farm animals involved in transgenesis will facilitate the use of the safest experimental protocols as well as the selection and propagation of the healthiest animals and, thereby, enable technological progress that could be ethically justified

Selection of critical factors for identifying emerging food safety risks in dynamic food production chains

A pro-active emerging risk identification system starts with the selection of critical factors related to the occurrence of emerging hazards. This paper describes a method to derive the most important factors in dynamic production chains starting from a gross list of critical factors. The method comprised the semi-quantitative evaluation of the critical factors for a relatively novel product on the Dutch market and a related traditional product. This method was tested in an expert study with three case studies. The use of group discussion followed by individual ranking in an expert study proved to be a powerful tool in identifying the most important factors for each case. Human behaviour (either producers’ behaviour or human knowledge) was the most important factor for all three cases. The expert study showed that further generalization of critical factors based on product characteristics may be possibl

Selection of critical factors for identifying emerging food safety risks in dynamic food production chains

A pro-active emerging risk identification system starts with the selection of critical factors related to the occurrence of emerging hazards. This paper describes a method to derive the most important factors in dynamic production chains starting from a gross list of critical factors. The method comprised the semi-quantitative evaluation of the critical factors for a relatively novel product on the Dutch market and a related traditional product. This method was tested in an expert study with three case studies. The use of group discussion followed by individual ranking in an expert study proved to be a powerful tool in identifying the most important factors for each case. Human behaviour (either producers’ behaviour or human knowledge) was the most important factor for all three cases. The expert study showed that further generalization of critical factors based on product characteristics may be possibl

Profitability of insect farms

Despite growing interest from entrepreneurs, knowledge on the profitability of commercial-scale insect production is scarce. Insight into the economic figures of insect production is needed by farmers aiming to start insect farms, by banks seeking to provide financing, and by governments planning policy interventions. This review provides an overview of the profitability and underlying economic figures relating to the production of Hermetia illucens, Alphitobius diaperinus, Tenebrio molitor and Acheta domesticus. To enhance data interpretation, we also provide a brief overview of the global insect sector, with specific attention to farm-level operational practices. Sales prices refer to fresh larvae, dried larvae or larvae meal, whereas operational costs include costs for feed, labour, electricity, water and gas. Operational cost components differ per insect species, and therefore the relevant margins are specified for three insect species. The energy, feed, and labour margin for production of H. illucens ranges from € -798 to 15,576 per tonne of dried larvae. The feed and labour margin for production of T. molitor ranges from € 7,620 to 13,770 per tonne of fresh larvae. For production of A. domesticus the feed margin ranges from € 12,268 to 78,676 per tonne of larvae meal. The margin range for A. diaperinus cannot be estimated, due to a lack of data in the literature. The ranges mainly reflect the differences in sales prices, which are found to heavily depend on the geographical market location, type of market (feed or food) and quantity sold. Major operational costs include feed and labour, with feed costs varying substantially within and between insect species. The economic figures and margins presented in this article provide a foundation for the further development of the insect production sector

Barriers, risks and risk management strategies in European insect supply chains

Despite technological developments and regulatory improvements, most actors in the insect sector still face many challenges and uncertainties. While previous research mainly focused on the perception of domain-specific challenges and risks or has been limited to specific stages in the supply chain, this study aims to determine how stakeholders perceive the importance of past barriers and future risks along European insect supply chains, and to identify the applied risk management strategies. Data were collected from stakeholders across four stages of the supply chain (rearers (n=23), processors (n=8), and insect derived feed (n=14), and food (n=12) producers) through an online survey. In total, 60 different barriers and risks, as well as 20 different risk management strategies, were evaluated. We find that stakeholders across all stages of the supply chain perceived ‘financial, cost and market’ barriers and risks as most important, specifically referring to the lack of financial investments and price and demand uncertainties. In addition, legal restrictions were perceived to constrain upscaling opportunities across all supply chain stages. Worker and food safety barriers were generally perceived as least important. The main risk management strategies across all stages of the supply chain related to investments in technologies enhancing stability of both the quality and the quantity of insects and derived products. Stakeholders were most optimistic about the future reduction of ‘operational’ and ‘financial, cost and market’ risks. To further stimulate upscaling of the sector, we recommend to enhance financing opportunities, and to improve authorisations for the use of different substrates and the production of a wider set of insect-based ingredients for feed and food products