827 research outputs found

    The Formulation of the Cultural Identity of Interior Architecture Students through the Educational Globalization

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    Educational Globalization debilitates the identities, the origins and cultural, religious, etymological, racial, and ethnic foundationsā€” challenge a country's feeling of solidarity and cohesion. The incorporation of cultural beliefs and the ensuing generationsā€™ patterns into the society is an essential test of globalization. Neglecting to do so; however, will have long haul social ramification. The capacity to define a character that permits agreeable development between universes will be at the very heart of accomplishing a really "worldwide soul". This research provides insights into a critical question: How are identity and agency implicated in educational processes and outcomes? Thus, the paper discusses the role of educational institutions, led by the Fine Arts and Applied Arts, with its leading role in facing the educational globalization and the dominance of foreign countries on Arab societies in the way of clothing, food and even individual behaviors. Certainly, the young designers, in the university student age, are influenced by the wave of westernization they face day and night

    Whey protein enhances normal inflammatory responses during cutaneous wound healing in diabetic rats

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    <p>Abstract</p> <p>Background</p> <p>Prolonged wound healing is a complication of diabetes that contributes to mortality. Impaired wound healing occurs as a consequence of excessive reactive oxygen species (ROS) production. Whey protein (WP) is able to reduce the oxygen radicals and increase the levels of the antioxidant glutathione. Thus, the aim of this study was to determine whether dietary supplementation with WP could enhance normal inflammatory responses during wound healing in diabetic rats. Animals were assigned into a wounded control group (WN), a wounded diabetic group (WD) and a wounded diabetic group orally supplemented with whey protein (WDWP) at a dose of 100 mg/kg body weight.</p> <p>Results</p> <p>Whey protein was found to significantly decrease the levels of malondialdehyde (MDA), nitric oxide (NO) and ROS. A significant restoration of the glutathione level was observed in WDWP rats. During the early wound healing stage, IL-1Ī², TNF-Ī±, IL-6, IL-4 and neutrophil infiltration were significantly decreased in WD mice. WP supplementation was found to restore the levels of these inflammatory markers to the levels observed in control animals. In addition, the time required for wound healing was significantly prolonged in diabetic rats. WP was found to significantly decrease the time required for wound healing in WDWP rats.</p> <p>Conclusion</p> <p>In conclusion, dietary supplementation with WP enhances the normal inflammatory responses during wound healing in diabetic mice by restoring the levels of oxidative stress and inflammatory cytokines.</p

    Fabrication and characterizations of additively manufactured PVDF-HFP composites for potential force sensing applications

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    Polyvinyldene fluoride (PVDF) and its copolymers have attracted considerable interest among researchers as piezoelectric materials since their discovery. Due to their satisfactory piezoelectric properties and excellent mechanical characteristics, they have found various applications, including in flexible force sensors. Researchers often reinforced the polymer matrix with fillers to enhance its performance as force sensors. However, the solvents commonly used in the mixing process were often deemed hazardous and toxic, leading to the search for an alternative. Among the potential fabrication methods, researchers have reported that using Fused Deposition Modeling (FDM) to 3D print PVDF composites has resulted in improved piezoelectric performance. In this study, a copolymer of PVDF, Polyvinyldene fluoride- hexaflouropropylene (PVDF-HFP), was reinforced and 3D printed to investigate the influence of the fillers on its piezoelectric characteristics and identify the effect of the printing parameters on its piezoelectric and mechanical properties. Initially, the pure polymer was 3D printed to investigate the effect of the printing parameters and the Design of Experiment (DOE) method was employed to optimize the printing parameters. The composite was synthesised through the solution casting of a PVDF-HFP matrix reinforced with Barium Titanate and Untreated Activated Carbon. To investigate its viability as an alternative solvent, Dimethylsulfoxide (DMSO) was selected as the solvent. The optimum mixture design of experiments (MDOE) method was employed to assist in investigating the effect of the fillers and help optimize the filler content in the matrix. The utilization of the MDOE was successful, and the formulation of 84.21 wt.% PVDF-HFP, 15.00 wt.% BTO, and 0.79 wt.% UAC predicted by the software recorded the maximum Ī²-phase of 71.895%. It is also worth noting that DMSO was deemed a viable alternative due to the tested formulations recording Ī²-phase content values that are comparable to values reported in literature. The DOE analysis run on the pure PVDF-HFP showed that using a higher printing temperature, lower printing speed, and thinner layer thickness resulted in a maximised Ī²-phase content. The following information were carried forward to aid in printing the PVDF-HFP composite. It was shown that the printed composite recorded a lower force sensitivity when compared to the pure polymer despite the slightly higher Ī²-phase. Despite limited performance, all printed samples still demonstrated piezoelectricity and were capable of detecting forces as low as 1N confirming that FDMprinted PVDF copolymer composites have potential as flexible force sensors

    Developmental-Based Classification of Enkephalin and Somatostatin Containing Neurons of the Chicken Central Extended Amygdala

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    The central extended amygdala, including the lateral bed nucleus of the stria terminalis and the central amygdala, plays a key role in stress response. To understand how the central extended amygdala regulates stress it is essential to dissect this structure at molecular, cellular and circuit levels. In mammals, the central amygdala contains two distinct cell populations that become active (on cells) or inactive (off cells) during the conditioned fear response. These two cell types inhibit each other and project mainly unidirectionally to output cells, thus providing a sophisticated regulation of stress. These two cell types express either protein kinase C-delta/enkephalin or somatostatin, and were suggested to originate in different embryonic domains of the subpallium that respectively express the transcription factors Pax6 or Nkx2.1 during development. The regulation of the stress response by the central extended amygdala is poorly studied in non-mammals. Using an evolutionary developmental neurobiology approach, we previously identified several subdivisions in the central extended amygdala of chicken. These contain Pax6, Islet1 and Nkx2.1 cells that originate in dorsal striatal, ventral striatal or pallidopreoptic embryonic divisions, and also contain neurons expressing enkephalin and somatostatin. To know the origin of these cells, in this study we carried out multiple fluorescent labeling to analyze coexpression of different transcription factors with enkephalin or somatostatin. We found that many enkephalin cells coexpress Pax6 and likely derive from the dorsal striatal division, resembling the off cells of the mouse central amygdala. In contrast, most somatostatin cells coexpress Nkx2.1 and derive from the pallidal division, resembling the on cells. We also found coexpression of enkephalin and somatostatin with other transcription factors. Our results show the existence of multiple cell types in the central extended amygdala of chicken, perhaps including on/off cell systems, and set the basis for studying the role of these cells in stress regulation.Funded by grants from the Spanish Ministerio de Ciencia e InnovaciĆ³n (Agencia Estatal de InvestigaciĆ³n, Grant no. PID2019-108725RB-100) and the European Unionā€™s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 812777 (H2020-MSCA-ITN-2018-812777). AHM and AP have contracts as Early-Stage Researchers paid by the H2020- MSCA-ITN-2018-812777 project. The authors declare that the funders were not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit It for publication
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