Report on the Disabled Persons Loan Scheme of Project Ken/86/037

No142.pdf: 428 downloads, before Oct. 1, 2020

BodilyPishu: Construction of Lambda Calculus

Many cryptographers would agree that, had it not been for interrupts, the evaluation of local-area networks might never have occurred [19]. In this position paper, we show the deployment of Smalltalk, which embodies the natural principles of theory [9]. In our research we verify that al- though the foremost distributed algorithm for the investigation of neural networks by Zheng and Brown runs in O(log n) time, consistent hashing and erasure coding can collaborate to fix this challenge

Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells.

Aberrant cytokine signaling initiated from mutant receptor tyrosine kinases (RTKs) provides critical growth and survival signals in high risk acute myeloid leukemia (AML). Inhibitors to FLT3 have already been tested in clinical trials, however, drug resistance limits clinical efficacy. Mutant receptor tyrosine kinases are mislocalized in the endoplasmic reticulum (ER) of AML and play an important role in the non-canonical activation of signal transducer and activator of transcription 5 (STAT5). Here, we have tested a potent new drug called imipramine blue (IB), which is a chimeric molecule with a dual mechanism of action. At 200-300 nM concentrations, IB is a potent inhibitor of STAT5 through liberation of endogenous phosphatase activity following NADPH oxidase (NOX) inhibition. However, at 75-150 nM concentrations, IB was highly effective at killing mutant FLT3-driven AML cells through a similar mechanism as thapsigargin (TG), involving increased cytosolic calcium. IB also potently inhibited survival of primary human FLT3/ITD+ AML cells compared to FLT3/ITDneg cells and spared normal umbilical cord blood cells. Therefore, IB functions through a mechanism involving vulnerability to dysregulated calcium metabolism and the combination of fusing a lipophilic amine to a NOX inhibiting dye shows promise for further pre-clinical development for targeting high risk AML

Actualizing Best Care Practices at a Psychiatric Treatment Center to Validate the Asset of an On-Site Electrocardiogram

Considerations to be contemplated in daily health delivery systems are complex and require varied approaches to deliver best-care processes that produce optimal patient outcomes. Specialty practice sites not only require the capability but also necessitate proficiency and dedication in meeting and exceeding essential healthcare competencies. A psychiatric treatment center specialty practice was the setting for this DNP project. The focus of this project included: (1) care resourcefulness, (2) safety initiatives, (3) increased privacy and confidentiality compliance, and (4) cost-efficiency measures. Technology use beyond the security of the safety available within the treatment complex is a current policy at the psychiatric treatment center producing suboptimal results. This project addressed the suboptimal care processes resulting from the use of the emergency department (ED) for the admitting electrocardiogram (ECG). Concentrated methods in support of this project change initiative included (1) literature research, (2) patient charting, (3) organizational expenses, (4) two policy briefs, and (5) two surveys. Project methods produced successful outcomes in acceptance of this project’s initiative. Literature supported decreased use of EDs for nonurgent health needs along with extensive recommendations in support of the clinical ECG. Extrapolated data exhibited greater sub-optimal care processes associated with obtaining the ECG at the ED than anticipated, as well as the generation of significant organizational costs. Policy briefings contained concise research results in support of an on-site ECG. Surveyors were in favor of the presented project solution. The purchase of an ECG will be a short-term technological investment that will produce profitable long-term returns in care quality and care delivery as well as being financially resourceful

AN INVESTIGATION OF MICROSEISMICITY DURING THE 2018 KILAUEA CALDERA COLLAPSE

The 2018 Kīlauea volcano eruption and incremental caldera collapse was accompanied by more than 60,000 seismic events cataloged by the Hawaiian Volcano Observatory as well as 62 caldera collapse events that occurred roughly once per day. The majority of seismicity occurred on the eastern side of the caldera between daily collapses. However, the majority of caldera subsidence occurred to the west. To understand the collapse mechanics behind this variance in subsidence and seismicity across the caldera region, repetitive waveforms and source properties can be studied. Repeating seismic events suggest a common source that is not moving or destroyed. At Kīlauea, clusters of repeating events can indicate source processes throughout collapse cycles. REDPy, a repeating earthquake detector tool for Python, cross correlates seismic events to determine repetition. Events are separated into families or listed as orphans if no matches are found. We used data from HVO network stations surrounding Kīlauea’s summit. Possible events were identified using an STA/LTA trigger algorithm with a long-time average trigger of 8 seconds, a short-time average trigger of 1 second, and a trigger on/off range of 1-2.5. A minimum correlation coefficient of 0.7 was used to group over 167,000 recognized events from April 29th to August 2nd into nearly 6,000 families. Of these families, 697 were chosen as ‘clusters of interest’ for including \u3e100 events or persisting for 7 days or more. P-wave first-motions were manually picked for waveforms associated with clusters of interest, these clusters were then located using P-wave arrival times, and focal mechanisms were modeled for viable events to learn more about their source processes and relationship to collapse mechanics. Dilatational first motions dominate our catalog and focal mechanism models have mismatched station polarities indicative of non-double-couple sources. In fact, focal spheres show evidence of reverse motion on ring faults, which is the opposite sense of slip associated with the large, daily caldera collapse events. This change in slip direction suggests that much of the microseismicity results from shortening within the down dropped caldera and rebound in areas adjacent to the caldera

Work team diversity and team effectiveness : a correlational field study

The purpose of this study was to investigate the relationships between team diversity, defined as the magnitude of differences within teams in terms of race, gender, age, personality, and values, and team effectiveness. Team effectiveness was defined in terms of performance, internal viability, and external viability. It was hypothesized that overall diversity could be meaningfully measured in a single index and that the relationship of diversity with effectiveness would be moderated by characteristics of the teams\u27 tasks as well as by team cohesion. In addition, this study compared the predictive ability of the single diversity index with the more traditional approach of measuring individual attribute heterogeneities and regressing effectiveness measures on those heterogeneity scores. The personality and values components of diversity were measured via the Myers-Briggs Type Indicator and the Bowling Green Survey of Work Values. Demographic information was also collected from participants (n=390) who were all employees of a large government agency. Team effectiveness measures were collected via a survey administered to team members as well as through a supervisor\u27s survey. Team diversity as measured by the index showed a relatively low, but significant correlation with perceived diversity. However, team tenure was found to moderate this relationship. Low tenured teams showed no correlation between diversity and perceived diversity, whereas higher tenured teams showed a strong positive correlation. Diversity was directly related only to team members\u27 ratings of overall quantity of work. The relationship between diversity and supervisors\u27 ratings of quantity was moderated by task complexity. Team cohesion was found to moderate the relationship between diversity and supervisors ratings of creativity. The traditional individual attribute approach of measuring diversity was found to be more predictive of team effectiveness. Using this approach,personality and gender diversity were significant predictors of team quality, age diversity predicted team quantity, and gender diversity predicted team effectiveness. Perceived diversity was found to be predicted by race and gender heterogeneity, and was positively correlated with team member ratings of creativity, teamwork, capability, cohesion, continuity, and communication

Evaluating the winter diet of a reintroduced herd of elk in the Cumberland Mountains, Tennessee, using next-generation sequencing techniques

A distinct subspecies of elk (Cervus canadensis), the North American elk (C. canadensis canadensis), once inhabited portions of the southeastern United States, including Tennessee, until their extirpation in the mid 1800s. From 2000 to 2008, 201 Manitoban elk were reintroduced on the North Cumberland Wildlife Management Area (NCWMA). A year-long food habits study using histological analysis of plant material from feces was completed for the NCWMA elk from 2003 to 2004 and has since aided managers in their landscape planning. Since then, more elk have been released onto the area, food plots have been established throughout the NCWMA, and the population has had approximately 20 years to establish itself on the landscape. Thus, a reevaluation of dietary habits is warranted. We collected 357 groups of fecal pellets from 68 set openings within the 79,318 ha NCWMA weekly from February to April of 2019 for a winter fecal diet analysis using next-generation sequencing techniques, also referred to as metabarcoding. Metabarcoding is a non-invasive methodology that has proven to be more effective in identifying herbivore diets than previously used methods. We conducted DNA extractions, a two-step polymerase chain reaction protocol, and completed library preparation of the samples using the Illumina MiSeq sequencing protocol to isolate the plant DNA from the other genetic material in the scat. A bioinformatical analysis was then conducted to determine what plants were identified from sequencing. Statistical analyses performed include calculating proportions for the genera detected from sequencing, determining if specific plants were used differently by males and females from specific genetic groups on the NCWMA, investigating alpha and beta diversity of sample sequences, and assessing the use of forage classes by elk during the winter of 2019. The results from this study will further inform managers of the dietary habits of the reintroduced NCWMA herd and assist them in future habitat management

Investigating π0 and η Production from STAR 2013 Endcap Calorimeter Data

The Solenoidal Tracker at RHIC (STAR) experiment, located at Brookhaven National Laboratory, uses collisions of longitudinally polarized proton beams produced in the Relativistic Heavy Ion Collider (RHIC) to study the gluon contribution to the proton spin. While the proton spin is known to be 1/2 ħ, the contribution from gluon spin is not precisely known. Our analysis uses 300 pb-1 of √s = 510 GeV collisions to determine the asymmetry of spin-dependent production of neutral pions (π0) and eta (η) mesons. This asymmetry is sensitive to the gluon contribution to the spin of the proton. Collisions at √s = 510 GeV have enhanced sensitivity to low x gluons, where x is the fraction of the proton’s momentum carried by the gluon, compared to other STAR analyses. π0s and ηs are produced within the STAR detector via collisions of longitudinally polarized protons provided by RHIC. The π0s and ηs rapidly decay into two photons, which are detected by the Endcap Electromagnetic Calorimeter stationed at a pseudorapidity range of 1.1 \u3c η \u3c 2.0. An invariant mass spectrum is constructed from the photon pairs. From this, the total number of π0s and ηs can be determined. Various quality assurance checks are performed to ensure a thorough understanding of the performance of the STAR detector system and to confirm the robustness of data collection at STAR. The current status of the asymmetry analysis, focusing on the 2013 dataset, will be presented

Disability issues, trends and recommendations for the World Bank

This paper is intended to provide the World Bank with the information, and insights necessary for policy formulation, and strategic planning in the area of disability. After describing the two major contemporary disability definitions, and comparing their suitability for disability policy, and planning, the paper presents a descriptive analysis of the evolution, and current status of disability policy, and practice. Based on this information, a political and economic case is made in favor of investing public, and private resources, including World Bank resources, in policies and strategies designed to increase access for people with disabilities to social, and economic opportunities. The essential elements of such policies, and strategies are then described, and incorporated into a strategic framework for possible use by the World Bank in its ongoing effort to develop appropriate, and cost-effective approaches to disability.Health Monitoring&Evaluation,Social Protections&Assistance,Social Cohesion,Gender and Law,Work&Working Conditions