DETERMINING THE OPTIMAL INVESTMENT AMOUNT OF AN INTELLIGENT HOUSE - POTENTIALS OF INFORMATION AND TECHNOLOGY TO COMBINE ECOLOGY AND ECONOMY

Innovations in the field of information systems (IS) open up new possibilities to increase energy efficiency and carbon reduction. For this, real estate is an industry sector with remarkably high potential. Here IS are integrated into \u27Intelligent Houses\u27. But many of these ecologically advantageous investments are not made yet, because they do not seem to be economically profitable. We therefore develop an IS-specific model to identify investment alternatives out of all ecologically advantageous investment alternatives which are also economically profitable. For this, we compare the investment amount with the achievable energy cost reduction and the raise of the buildings\u27 resale returns. Out of all identified investments we determine the economically optimal investment amount. In this connection we put special emphasis on the valuation of risk and for the first time point out the applicability of Intelligent Houses as insurance against energy price volatility. Thus the quantity of all ecologically advantageous and economically profitable investments is enhanced as well as the economically optimal investment amount. IS\u27 potentials to combine economy and ecology can thus be detected and made useable. An example illustrates how the model can be applie

Nascent craft specialization in the Pre-Pottery Neolithic A? Bead making at Shubayqa 6 (northeast Jordan)

The emergence of craft specialisation is a key area of interest for archaeologists investigating the socio-economic history and development of past societies. In southwest Asia, as elsewhere, the origins of craft specialisation have been associated with the emergence of surplus food production, households and social stratification. We present evidence for nascent skilled production of green stone beads at the Pre-Pottery Neolithic A (PPNA) site Shubayqa 6, northeast Jordan. Thousands of pieces of debitage, roughouts and finished beads exhibit signs of standardised production that was probably geared towards exchange. This hints towards incipient skilled craft production that was likely part-time and seasonal. We therefore argue that the appearance of specialist artisans in this autonomous and non-hierarchical society has no correlation with surplus food production, households, or social stratification

Modelling Dominant Tree Heights of Fagus sylvatica L. Using Function-on-Scalar Regression Based on Forest Inventory Data

European beech (Fagus sylvatica L.) is an important tree species throughout Europe but shifts in its suitable habitats are expected in the future due to climate change. Finding provenances that are still economically viable and ecologically resilient is an ongoing field of research. We modelled the dominant tree heights of European beech as a trait reflecting growth performance dependent on provenance, climate and soil conditions. We derived dominant tree heights from national forest inventory (NFI) data from six European countries spanning over large ecological gradients. We performed function-on-scalar regression using hierarchical generalized additive models (HGAM) to model both the global effects shared among all provenances and the effects specific to a particular provenance. By comparing predictions for a reference period of 1981-2010 and 2071-2100 in a RCP 8.5 scenario, we showed that changes in growth performance can be expected in the future. Dominant tree heights decreased in Southern and Central Europe but increased in Northern Europe by more than 10 m. Changes in growth performance were always accompanied by a change in beech provenances, assuming assisted migration without dispersal limitations. Our results support the concept of assisted migration for the building of resilient future forests and emphasize the use of genetic data for future growth predictions

Group-based exercise in daily clinical practice to improve physical fitness in men with prostate cancer undergoing androgen deprivation therapy:study protocol

INTRODUCTION: Level 1 evidence supports the use of supervised exercise to mitigate the adverse effects of androgen deprivation therapy (ADT) in men with prostate cancer. The data, however, have been generated in controlled research settings and might not be transferable to daily clinical practice. This article describes the design of an ongoing prospective observational study to evaluate the potential benefits of exercise in daily clinical practice. METHODS AND ANALYSIS: Men diagnosed with prostate cancer starting or already receiving ADT at our facility are invited to participate in a 12-week exercise programme implemented as the standard of care. Exclusion criteria are opioid-demanding treatment for skeletal pain, an Eastern Cooperative Oncology Group (ECOG) performance status above 2 or the inability to perform floor and machine exercises independently. The intervention consists of an initial educational session of 1½ hours followed by 12 weeks of group-based supervised training two times a week. The focus of the exercise is progressive resistance training in combination with aerobic training. Participants are measured at baseline, after 12 weeks and after 24 weeks as part of the programme. Primary endpoints of this study are changes in physical fitness evaluated by the 30 s Chair-Stand Test and Graded Cycling Test with Talk Test. Secondary endpoints include changes in quality of life, body composition and safety of exercise. Inclusion started in August 2014, with 169 participants being included by December 2015. ETHICS AND DISSEMINATION: The study has been reviewed by the Scientific Ethical Committee of the Capital Region of Denmark (reference number H-3-2013-FSP39). The results of the study will be published in peer-reviewed international journals and will be presented at national and international conferences and symposiums. TRIAL REGISTRATION NUMBER: NCT02631681; Pre-results

Concluding destructive investigation of a nine-year-old marine-exposed cracked concrete panel

This study undertaken on a nine-year-old cracked concrete panel further investigates the impact of cracks on the corrosion performance of conventional steel reinforcement in marine-exposed concrete to explain observed monitoring data. The present data covers seven 1.80 m long (12.6 m) reinforcing bars embedded in good quality concrete (w/b = 0.40 and cover >75 mm). Each bar was crossed by two horizontal cracks (surface crack widths 0.20–0.30 mm). The investigation showed no corrosion on the surface of the reinforcing bars, in either cracked or uncracked areas. Two of the seven reinforcing bars were instrumented in the vicinity of the cracks. Extensive corrosion was found in the interior of all instrumented parts of these bars. This may explain the monitoring data despite the lack of corrosion on the exterior surface of the two instrumented rebars. However, with no other weaknesses, the remaining conventional rebars showed no impact from the cracks

Concluding destructive investigation of a nine-year-old marine-exposed cracked concrete panel

This study undertaken on a nine-year-old cracked concrete panel further investigates the impact of cracks on the corrosion performance of conventional steel reinforcement in marine-exposed concrete to explain observed monitoring data. The present data covers seven 1.80 m long (12.6 m) reinforcing bars embedded in good quality concrete (w/b = 0.40 and cover >75 mm). Each bar was crossed by two horizontal cracks (surface crack widths 0.20–0.30 mm). The investigation showed no corrosion on the surface of the reinforcing bars, in either cracked or uncracked areas. Two of the seven reinforcing bars were instrumented in the vicinity of the cracks. Extensive corrosion was found in the interior of all instrumented parts of these bars. This may explain the monitoring data despite the lack of corrosion on the exterior surface of the two instrumented rebars. However, with no other weaknesses, the remaining conventional rebars showed no impact from the cracks.publishedVersio

The real-world outcomes of multiple myeloma patients treated with daratumumab

Most patients cannot be included in randomized clinical trials. We report real-world outcomes of all Danish patients with multiple myeloma (MM) treated with daratumumab-based regimens until 1 January 2019. METHODS: Information of 635 patients treated with daratumumab was collected retrospectively and included lines of therapy (LOT), hematologic responses according to the International Myeloma Working Group recommendations, time to next treatment (TNT) and the cause of discontinuation of treatment. Baseline characteristics were acquired from the validated Danish Multiple Myeloma Registry (DMMR). RESULTS: Daratumumab was administrated as monotherapy (Da-mono) in 27.7%, in combination with immunomodulatory drugs (Da-IMiD) in 57.3%, in combination with proteasome inhibitors (Da-PI) in 11.2% and in other combinations (Da-other) in 3.8% of patients. The median number of lines of therapy given before daratumumab was 5 for Da-mono, 3 for Da-IMiD, 4 for Da-PI, and 2 for Da-other. In Da-mono, overall response rate (ORR) was 44.9% and median time to next treatment (mTNT) was 4.9 months. In Da-IMiD, ORR was 80.5%, and mTNT was 16.1 months. In Da-PI, OOR was 60.6% and mTNT was 5.3 months. In patients treated with Da-other, OOR was 54,2% and mTNT was 5.6 months. The use of daratumumab in early LOT was associated with longer TNT (p<0.0001). Patients with amplification 1q had outcome comparable to standard risk patients, while patients with t(4;14), t(14;16) or del17p had worse outcome (p = 0.0001). Multivariate analysis indicated that timing of treatment (timing of daratumumab in the sequence of all LOT that the patients received throughout the course of their disease) was the most important factor for outcome (p<0.0001). CONCLUSION: The real-world outcomes of multiple myeloma patients treated with daratumumab are worse than the results of clinical trials. Outcomes achieved with daratumumab were best when daratumumab was used in combination with IMIDs and in early LOT. Patients with high-risk CA had worse outcomes, but patients with amp1q had similar outcomes to standard-risk patients