Portrait: les nombreuses facettes de Toussaint Louverture

Toussaint Louverture\u27s groundbreaking revolutionary war against slavery in the French colony of Saint-Domingue has earned him a well-deserved place in the history of anti-colonial movements. Despite his arrest and subsequent deportation to France, he is remembered as one of the founders of the first Haitian nation. Metellus goes beyond this image of the Haitian leader and captures him in all his complexity; his limits as a human being and as a leader. However, Metellus ultimately wants us to remember Toussaint Louverture as one of the founders of the anti­colonial movement

Breaking the Shackles of Shame

Shame is the intensely painful feeling or experience of believing that we are flawed and therefore unworthy of love and belonging (Brown, 2012, p.41). It can be classified as toxic shame, which occurs when shame exceeds healthy boundaries to engender self-hatred, despair, and worthlessness (Bradshaw, 2005; Brown, 2012); and healthy shame, which teaches us about our limits (Bradshaw, 2005, p.18). This paper will describe the nuance between the two and provide the historical and psychological depiction of shame at large. A drama therapeutic framework on the matter will also be established

Studying Factors of Environmental Injustice and Ways to Achieve Equity

In today\u27s day of age, the biggest concern for current and future generations: the environment. The urban heat island (UHi) with its significant energy, health, and societal impacts is among the major environmental issues in urban regions, especially in historically underserved and socially vulnerable communities (HUSVCs). In the 1930s, the former federal agency, Homeowners\u27 Loan Corporation (H0Lq, created \u27\u27Residential Security maps of major cities, known today as redlined areas. These neighborhoods were often designated as hazardous due to the high percentages of people of color living there, leading to systematic disinvestment based on race. While the program ended in 1968, the impacts of discriminatory lending are still experienced in redlined areas in the form of urban hotspots. The advent of new technologies and availability of environmental data from satellite and ground observations such as ArcGIS and QGIS, could improve our understanding of these heat impacts and be used to develop and assess mitigation and resiliency strategies

Rôle de l'adrénomédulline dans la néoangiogenèse et l'invasion tumorale

Les glioblastomes sont des tumeurs fatales du fait de leur agressivité et du manque de traitements efficaces. La prolifération accrue, le caractère invasif et la résistance à la mort cellulaire leur confèrent une croissance rapide et une invasion du parenchyme cérébral environnant, à l origine de leur systématique récidive. Exprimée par la composante tumorale en hypoxie mais également par la composante vasculaire, l AM participe de façon autocrine et paracrine au développement des glioblastomes en favorisant la croissance des cellules tumorales et l angiogenèse tumorale.Il a été montré que des anticorps polyclonaux dirigés contre les récepteurs de l AM inhibent in vitro la croissance, la migration et la formation de pseudo-capillaires des cellules endothéliales, suggérant une neutralisation par ces anticorps de certaines étapes de l angiogenèse. De même, il a été montré in vivo que ces anticorps inhibent la croissance tumorale en supprimant l angiogenèse et la croissance des cellules tumorales suggérant ainsi que les récepteurs de l AM constitueraient une bonne cible thérapeutique. Des anticorps capables de reconnaître et neutraliser à la fois l AM, les CLR, RAMP2 et RAMP3 agissant de la même manière sur la croissance tumorale et l angiogenèse représenteraient un bénéfice thérapeutique majeur. Des anticorps dirigés contre un peptide chimérique constitué de l enchainement de séquences peptidiques des protéines CLR, RAMP2, RAMP3 et du peptide AM sont en cours. Le traitement par ces anticorps diminue la croissance des cellules tumorales ainsi que leurs migration et invasion. Ces résultats très encourageants nous permettent pour le moment de valider la faisabilité du concept d anticorps développés à partir d un peptide chimérique pour neutraliser le système AM/AMR dans le but d envisager dans le futur une application thérapeutique.Glioblastoma are fatal tumors because of their aggressiveness and lack of effective treatments. The increased proliferation, the invasiveness and resistance to cell death gives them a rapid growth and invasion of brain parenchyma surrounding the origin of their systematic recurrence. Expressed by the tumoral component in hypoxia but also by the vascular component, the AM participate by an autocrine and paracrine way, the development of glioblastoma by promoting tumor ell growth and tumor angiogenesis.It was shown that polyclonal antibodies directed against the AM receptor inhibit in vitro growth, migration and the formation of pseudo-capillary of endothelial cells, suggesting neutralization by theses antibodies in certain stages of angiogenesis. Similarly, it has been shown in vivo that these antibodies inhibit tumor growth by suppressing angiogenesis and tumor cell growth, suggesting that the AM receptor would be a good therapeutic target. Antibodies that recognized and neutralized both the AM, the CLR, RAMP2 and RAMP3 acting the same way on tumor growth and angiogenesis represent a major therapeutic benefit. Antibodies against a chimeric peptide consisting of peptide sequence of CLR, RAMP2, RAMP3 and AM peptide are in progress. Treatment with these antibodies decreases the growth of tumor cells, their migration and invasion. These encouraging results allow us the time to validate the feasibility of the concept of antibodies developed from a chimeric peptide to neutralize the AM/AMR system in order to consider in the future therapeutic application.AIX-MARSEILLE2-Bib.electronique (130559901) / SudocSudocFranceF

Activity of insecticides on coffee berry borer (Hypothenemus hampei) (Coleoptera: curculionidae, scolytinae)

The objective of this work was to evaluate the topical, residual and agronomic effects of the insecticides Voliam Targo, Benevia, Lorsban 480 BR, Curbix 200 SC, Sperto, Verismo, Polytrin 400/40 CE, Curyom 550 EC, Polo 500 SC and Vertimec 18 EC in the control of the berry borer of coffee (H. hampei). The experimental design was completely randomized and four replicates were used in the trials. In the laboratory, a direct spray was sprayed on the insect (topical effect) and applied to the fruits of the coffee (residual contamination). In both experiments, each plot consisted of a Petri dish lined with filter paper, 10 fruits in the green stage and 10 adult females of the berry borer, originating from artificial breeding. Two field experiments were carried out at Campus Glória Experimental Farm. The first one was carried out with the objective of evaluating the residual effect of the insecticides on artificial infestation of the berry borer after applying the products to fruits at the beginning of maturation. The number of perforated fruits, dead females, number of eggs and larvae were evaluated in laboratory and field experiments. The second field experiment had as objective to evaluate the effectiveness in controlling the natural population of the berry borer. Two applications were performed with a 30-day interval, using a motorized turbocharger. The number of fruits bored in 50 fruits per plot and percentage of seeds bored in a sample of 250 seeds per replicate were evaluated. In the laboratory, all insecticides provided mortality higher than 80% in topical application and greater than 73% by residual contamination, except the insecticide Polo 500 SC, which provided a 55% mortality. In the field experiment with artificial infestation, all the insecticides differed from the control, maintaining residual control until 30 days after application and with mortality higher than 70%, reaching up to 100% of mortality. In the test with natural berry borer females infestation the insecticides differed from the control in all evaluated parameters, showed efficacy higher than 75% at 35 days after the second application. The insecticides Voliam Targo, Lorsban 480 BR, Curbix 200 SC, Sperto, Polytrin 400/40 CE and Verismo presented the best control results, being indicated for use in the management of the berry borer of coffee