Ultrastructural and Biochemical Changes of the Brain after Peripheral Administration of Phorbol Myristate Acetate

The ultrastructural and biochemical changes in the brain tissue of 20 mice were studied. The mice, separated into acute and chronic groups, were injected with phorbol myristate acetate (PMA) to trigger the release of free radicals. Malondialdehyde measurement and electron microscopic examination were applied for the evaluation of the effects of the free radicals. The level of lipid peroxide in the chronic PMA group was found to be significantly higher than it was in the acute PMA group (P &#60; 0.005). An electron microscopic examination of the acute group revealed disruption of the mitochondrial cristae and dilatation of the endoplasmic reticulum in the neurons. Myelin sheaths of the nerve fibers exhibited focal structural changes. Neurons and neuroglial cells in the chronic group, however, exhibited distinct ultrastructural alterations. The ultrastructural and biochemical findings showed that free radicals lead to brain damage.</p

An Inlet Patch Case with Difficulty Swallowing

Heterotopic Gastric Mucosa (inlet patch) is a clinical entity, described firstly by Schmit as a congenital anomaly, char-acterized by settling of gastric mucosa in any part of the gastrointestinal mucosa. It causes various clinical symp-toms due to acid secretion. Our case is oberved rarelly in case of inlet patch

Çeşitli hastalıkların karaciğer üzerine etkilerinin ince yapı düzeyinde araştırılması

TEZ956Tez (Uzmanlık) -- Çukurova Üniversitesi, Adana, 1991.Kaynakça (s. 33-39) var.63 s. : res. ; 30 cm.

Weaknesses in a Recently Proposed RFID Authentication Protocol

Abstract. Many RFID authentication protocols have been proposed to provide desired security and privacy level for RFID systems. Almost all of these protocols are based symmetric cryptography because of the limited resources of RFID tags. Recently Cheng et. al have been proposed an RFID security protocol based on chaotic maps. In this paper, we analyze the security of this protocol and discover its vulnerabilities. We firstly present a de-synchronization attack in which a passive adversary makes the shared secrets out-of-synchronization by eavesdropping just one protocol session. We secondly present a secret disclosure attack in which a passive adversary extracts secrets of a tag by eavesdropping just one protocol session. An adversary having the secrets of the tag can launch some other attacks

Qualitative Data Analysis of Information Technology Sector Job Advertisements Published on Electronic Employment Platforms in Turkey (2017-2018)

anemonIn this study, It has been planned a qualitativedata analysis (QDA) of IT Sector’s job advertisements those were posted by themost popular Turkish Job Seeking Internet Portals. In this paper Inductiveanalysis is targeted and one of the sub-branch of QDA, “Content Analysis” isused. It is considered that the coding and analysis IT sector job advertisementthat contain data of labor requirement of IT Companies in one year, related toconstitute a source about possible arrangement for IT sector labor market inthe future.Buçalışmada ülkemizde faaliyet gösteren önemli iş arama web sitelerinde 2017-2018döneminde yayınlanan bilişim sektörü iş ilanlarının niteliksel analizininyapılması hedeflenmiştir. Bu kapsamda NVivo programı ile nitel veri analizininbir alt unsuru olan içerik analizi çalışması yapılmıştır. Bir yıl içerisindebilişim sektöründe faaliyet gösteren firmaların ihtiyaç duyduğu işgücüne aitverilerin sergilendiği bilişim ilanları üzerinden gerçekleştirilen kodlama veanaliz çalışması ile sektörün istihdam yapısı incelenmiştir. Çalışmanın ileridegerçekleştirilecek bilişim sektörü işgücü piyasası düzenlemelerine kaynakoluşturacağı değerlendirilmektedir.45270

Factors Affecting Angiogenesis in Ovaries

Daha önce oluşan kan damarlarından filizlenme yoluyla yeni kan damarlarının oluşum süreci olan anjiyogenez, vücudumuzda hem fizyolojik hem de patolojik birçok durumda görülmektedir. Overlerde anjiyogenez, ovaryan siklusun foliküler ve luteal fazları sırasında normal ovaryan fizyolojik aktivasyonda ve çeşitli ovaryan hastalıklar ile neoplazilerde önemli rol oynamaktadır. Overlerde normal fonksiyon, anjiyogenezi etkileyen birçok proanjiyogenik ve antianjiyogenik faktörler aracılığıyla gerçekleşir. Bu faktörlerin en önemlileri vasküler endotelyal büyüme faktörü, fibroblast büyüme faktörü, anjiyotensin II ve matriks metalloproteinazlar olmakla birlikte, diğer birçok faktör de bu süreçte yer almaktadır. Günümüzde bu konuda artan bilgi birikimi birçok hastalığın patogenezinin anlaşılmasına ve tedavisinde yeni terapötik yaklaşımların ortaya çıkmasına olanak sağlayacaktırAngiogenesis is the process of new capillary formation from preexisting vessels that occurs in both the physiological and pathological processes in our body. Ovarian angiogenesis participates in normal ovarian physiologic activation, various ovarian diseases and neoplasms throughout the follicular and luteal phases of the ovarian cycle. The normal ovarian function modulated by a wide range of proangiogenic and antiangiogenic factors that directly affects angiogenesis. The most important of these factors are vascular endothelial growth factor, epidermal growth factor, fibroblast growth factor, angiotensin ıı, matrix metalloproteinases as well as many other factors are involved in this process. Today increased knowledge in this issues will enable the emergence of new therapeutic approaches in the understanding and treatment of pathogenesis of many disease

Türkiye’de Elektronik İstihdam Platformlarında Yayınlanan Bilişim Sektörü İş İlanlarının Nitel Analizi (2017-2018) (ICEESS'18)

anemonIn this study, It has been planned a qualitativedata analysis (QDA) of IT Sector’s job advertisements those were posted by themost popular Turkish Job Seeking Internet Portals. In this paper Inductiveanalysis is targeted and one of the sub-branch of QDA, “Content Analysis” isused. It is considered that the coding and analysis IT sector job advertisementthat contain data of labor requirement of IT Companies in one year, related toconstitute a source about possible arrangement for IT sector labor market inthe future.Buçalışmada ülkemizde faaliyet gösteren önemli iş arama web sitelerinde 2017-2018döneminde yayınlanan bilişim sektörü iş ilanlarının niteliksel analizininyapılması hedeflenmiştir. Bu kapsamda NVivo programı ile nitel veri analizininbir alt unsuru olan içerik analizi çalışması yapılmıştır. Bir yıl içerisindebilişim sektöründe faaliyet gösteren firmaların ihtiyaç duyduğu işgücüne aitverilerin sergilendiği bilişim ilanları üzerinden gerçekleştirilen kodlama veanaliz çalışması ile sektörün istihdam yapısı incelenmiştir. Çalışmanın ileridegerçekleştirilecek bilişim sektörü işgücü piyasası düzenlemelerine kaynakoluşturacağı değerlendirilmektedir.45270

Ultrastructural features of myocardium in progressive systemic sclerosis

Purpose: The present study involves with Ultrastructural changes of myocardium obtained from patients with progressive systemic sclerosis. Methods: Cardiac catheterization was performed in 11 patients with progressive systemic sclerosis. Myocardial biopsy samples were obtained from the right ventricular apex via femoral venous approach and processed for electron microscopy using conventional method. Results: Myofibrillar degeneration, mitochondrial abnormalities, reduplication of capillary basal lamina, increasement of collagen fibers and abundant mast cells containing dense or pale granules were the main Ultrastructural alterations. Conclusion: In accordance with the Ultrastructural observations it could be assumed that mast cells might be a factor in the pathogenesis of PSS.Purpose: The present study involves with Ultrastructural changes of myocardium obtained from patients with progressive systemic sclerosis. Methods: Cardiac catheterization was performed in 11 patients with progressive systemic sclerosis. Myocardial biopsy samples were obtained from the right ventricular apex via femoral venous approach and processed for electron microscopy using conventional method. Results: Myofibrillar degeneration, mitochondrial abnormalities, reduplication of capillary basal lamina, increasement of collagen fibers and abundant mast cells containing dense or pale granules were the main Ultrastructural alterations. Conclusion: In accordance with the Ultrastructural observations it could be assumed that mast cells might be a factor in the pathogenesis of PSS

Ultrastructural evaluation of the effects of the Contrast Media on the rat kidney

PubMedID: 11989778In this study, the ultrastructural observations in rat kidneys were studied 2, 24 and 48 h after intravenous injection of 1, 3 and 9 g iodine per kg body of ioxaglate and iohexol. The effect of die contrast media was mainly on the proximal convoluted tubule cells, the presence of vacuoles containing granular and membranous structures was a striking feature. In the distal convoluted tubular cells, pycnotic nuclei and cytoplasmic bulges toward the lumen were observed. In some glomeruli, membranous structures in cytoplasm of podocytes and thickening of glomerular basal membrane were seen. Values of biochemical analysis were slightly higher especially at high doses in experimental groups when compared to the control. The results suggest that iohexol causes more degeneration than ioxaglate. Not only proximal convoluted tubule cells but also the other parts of the nephron were affected by contrast media

Phorbol myristate acetate' in karaciğer üzerine etkileri: Biyokimyasal ve ultrastrüktürel bir çalışma

The effects of free radicals in the liver tissue of 20 mice were studied. The mice, separated into acute and chronic groups, were injected with phorbol myristate acetate (PMA) to trigger the release of free radicals. For evaluation of the effects of free radicals, malandialdehyde (MDA) measurement and electron microscopic examination were performed. The results showed that the level of lipid peroxide in the chronic PMA group was significantly higher than it was in the acute PMA group (<0.005). In the electron microscopic examination of liver biopsy materials of the acute group, a disruption of the inner mitochondrial membranes, an increase in lysosomes and a slight dilatation of the granular endoplasmic reticulum were observed. However, these structural changes were more prominent in the chronic group. It is concluded that injection of PMA results in the formation of free radicals and liver degeneration.The effects of free radicals in the liver tissue of 20 mice were studied. The mice, separated into acute and chronic groups, were injected with phorbol myristate acetate (PMA) to trigger the release of free radicals. For evaluation of the effects of free radicals, malandialdehyde (MDA) measurement and electron microscopic examination were performed. The results showed that the level of lipid peroxide in the chronic PMA group was significantly higher than it was in the acute PMA group (<0.005). In the electron microscopic examination of liver biopsy materials of the acute group, a disruption of the inner mitochondrial membranes, an increase in lysosomes and a slight dilatation of the granular endoplasmic reticulum were observed. However, these structural changes were more prominent in the chronic group. It is concluded that injection of PMA results in the formation of free radicals and liver degeneration