Adapazarı bölgesi zemin büyütme faktörünün incelenmesi

06.03.2018 tarihli ve 30352 sayılı Resmi Gazetede yayımlanan “Yükseköğretim Kanunu İle Bazı Kanun Ve Kanun Hükmünde Kararnamelerde Değişiklik Yapılması Hakkında Kanun” ile 18.06.2018 tarihli “Lisansüstü Tezlerin Elektronik Ortamda Toplanması, Düzenlenmesi ve Erişime Açılmasına İlişkin Yönerge” gereğince tam metin erişime açılmıştır.Bu çalışmanın amacı, Adapazarı bölgesinin yerel zemin koşullarının kuvvetli depremAdapazarı’nda geçmiş yıllarda yapılmış derin sondajlardan belirlenen zemi

Causality Between Real Effective Exchange Rate and Foreign Trade Volume : The Case of Turkey

Reel efektif döviz kuru ile dış ticaret hacmi arasındaki ilişki son yıllarda tartışı- lan önemli konulardan biridir. Bu çalışmada Türkiye'nin dış ticaret hacmi ile reel efektif döviz kuru arasındaki nedensellik ilişkisi araştırılmaya çalışılmış, 1997:1- 2014:12 dönemi için yapılan ampirik çalışmada sırasıyla; logaritması alınan se- riler mevsimsel etkilerden arındırıldıktan sonra ADF, Phillips-Perron ve KPSS bi- rim kök testleri uygulanarak, seriler durağan hale getirilmiştir. Granger neden- sellik analizi yapıldıktan sonra Koentegrasyon (eşbütünleşme) analizi uygulana- rak, dış ticaret hacmi ve reel efektif döviz kuru arasındaki nedensellik ilişki in- celenmiştir. Aynı zamanda reel efektif döviz kuru ile dış ticaret hacmi arasında eşbütünleşme ilişkisinin varlığı ortaya konulmuştur. Daha sonra uzun dönem eş- bütünleşme ve kısa dönem hata düzeltme modeli tahmin edilmiştir. Yapılan ana- lizler sonucunda elde edilen sonuçlara göre reel efektif döviz kurundan dış tica- ret hacmine doğru bir nedensellik ilişkisi olduğu, ancak dış ticaret hacminden reel efektif döviz kuruna doğru bir nedensellik ilişkisinin bulunmadığı tespit edilmiştir.The relationship between foreign trade and real exchange rate has been discus- sed in recent years. The purpose of this study is to assess the casual relationship between real exchange rate and foreign trade volume. In our empirical study per- formed using monthly data from January 1997 to December 2014, first, the loga- rithms of the series are clarified deseasonalised and then they have been tested with the ADF, Phillips-Perron and KPSS unit root tests. Granger casuality analy- sis has been made and using the cointegration analysis, the relationship betwe- en foreign trade volume and real exchange rate has been examined. Then the long-run and short-run error correction model was estimated . According to the result of analyses, a casual relationship has been found from real exchange to foreign trade volume however it has been determined that there is no casual re- lationship from foreign trade volume to real exchange rate

Investigation of proarrhythmic effect of high sugammadex doses: an experimental animal study

BackgroundStudies on higher doses of sugammadex effect on QT interval and leading arrhythmia have been limited. In this study, we aimed to investigate possible proarrhythmic effect of higher doses of sugammadex in conditions that required urgent reversal of neuromuscular blockade during general anesthesia in an experimental animal model.MethodsIt was experimental animal study. Total of 15 male New Zealand rabbits were randomly divided into three groups for low (4 mg/kg, n = 5), moderate (16 mg/kg, n = 5), and high dose of sugammadex (32 mg/kg, n = 5). All rabbits were premedicated by intramuscular ketamine 10 mg/kg, and general anesthesia was inducted by intravenous injection of 2 mg/kg of a propofol, 1 mcg/kg fentanyl, and 0.6 mg/kg rocuronium injection. Airway was provided by V-gel rabbit and connected to anesthetic device and ventilated at about 40 cycle/min and 10 ml/kg; oxygen 50% plus air 50% mixture was used with 1 MAC isoflurane to maintain anesthesia. Electrocardiographic monitorization and arterial cannulation were provided to follow-up mean arterial pressure and for arterial blood gas analyses. Intravenous sugammadex in three different doses were injected at 25th min of induction. After observing adequate respiration of all rabbits, V-gel rabbit was removed. Parameters and ECG recordings were taken basal value before induction and at the 5th, 10th, 20th, 25th, 30th, and 40th min to measure corrected QT intervals and were stored on digital media. QT interval was calculated as the time from the beginning of the Q wave to the end of the T wave. Corrected QT interval was calculated according to the Bazett's formula. Possible adverse effects were observed and recorded.ResultsIn all three groups, there was no significant statistical difference in mean arterial blood gases parameters, arterial pressures, heart rates, and Bazett QTc values, and no serious arrhythmia was recorded.ConclusionWe found in animal study that low, moderate, and high doses of sugammadex did not significantly altered corrected QT intervals and did not cause any significant arrhythmia

The instructor parameters of transition to fully online learning

Online learning has an old background and is an efficient method if applied correctly. However, during the pandemic period, it has been faced with a negative perception due to the wrong practices brought about by the mandatory and rapid transition. During this pandemic term, most educational institutions have offered support in this process to explain the process to both their students and instructors. This study examined XXX University instructors’ perspectives regarding the emergency remote teaching period in terms of their professional experience, discipline area, online instruction experience, and whether they received training in online instruction. Quantitative research methods were used in the study. An online instructor’s emergency remote teaching perspective scale has been developed and used as a data collection tool. A significant difference has been found in the discipline areas, online instruction experience, and participation in training program. From the results of the research, the need to support the instructors according to the needs specific to the disciplines has been revealed, and it is recommended to investigate the relationships between selfcompetency for online teaching and the perception of institutional support in depth

Simple markers for subclinical inflammation in the different phases of bipolar affective disorder

Abstract Background: Recently, a growing number of publications have suggested that the immune-inflammatory system may be involved in the etiology of bipolar disorder (BD). Objective: The aim of this study was to investigate neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and red cell distribution width (RDW) in the three different phases of BD patients compared to each other and controls. Methods: One hundred eighty-seven bipolar patients (78 euthymic, 53 manic/hypomanic and 56 depressed), and 62 age and sex matched controls were enrolled. Sociodemographic variables and complete blood count parameters of the patients and the control group were recorded. Results: The groups did not differ from each other on the hematological parameters, except for NLR and RDW. Post-hoc analyses revealed that NLR values were significantly higher in the euthymic and manic/hypomanic bipolar groups compared to control group. In addition, post-hoc analyses revealed that RDW values were significantly higher in the manic/hypomanic bipolar group relative to the control group. Discussion: Longitudinal studies evaluating the levels of inflammatory markers in the early phases of the disorder, and their relationship with the development of different episodes and medical comorbidities may be useful to understand the role of inflam mation in BD

Paraoxonase (PON1) L55M and Q192R polymorphisms in major depressive disorder and bipolar disorder

Objective: Oxidative and nitrosative stress pathways, along with immune-inflammatory response, might play an important role in the pathogenic mechanisms underlying major depressive disorder and bipolar disorder. The aim of the present study is to investigate paraoxonase 1 polymorphisms and its correlations with disease parameters in patients with major depressive disorder and bipolar disorder. Methods: PON1 L55M and Q192R single nucleotide polymorphisms were analyzed in a group consisted of 100 patients with major depressive disorder, and 100 patients with bipolar disorder and 96 healthy controls. Polymorphisms were analyzed by using polymerase chain reaction. Results: There were no statistically significant differences between groups for the existence of PON1 genotypes. Additionally, there was no association between the PON1 genotypes and disease variables in both depressed and bipolar patients. Conclusions: Evaluating the different stages of patients with mood disorders and examining the connection between PON1 polymorphisms and treatment outcomes will help us to clarify the relationship between PON1 and mood disorders.Publisher's Versio

Evaluation of conventional imaging techniques on preoperative localization in primary hyperparathyroidism

We aimed to evaluate the diagnostic and preoperative localization capacity of Tc-99m methoxyisobutylnitrile (MIBI) parathyroid scintigraphy and ultrasonography (USG) in enlarged parathyroid glands in the primary hyperparathyroidism (pH PT), as well as the relationship between the success rate of these techniques and biochemical values. We retrospectively evaluated 39 patients with clinical and biological evidence of pHPT who referred to the university hospital for MIBI parathyroid scintigraphy. Patients were examined with USG and double-phase MIBI parathyroid scintigraphy for the detection of enlarged parathyroid glands. Preoperative serum intact parathyroid hormone (iPTH) levels, calcium (Ca), phosphate and alkaline phosphatase measurements were obtained. A total of 45 parathyroid lesions in 39 patients were reviewed. Thirty-four patients had a single adenoma and five patients with multi-gland disease had 11 abnormal parathyroid glands including three adenomas, whereas the remaining 8 glands showed hyperplasia. The overall sensitivities of MIBI parathyroid scintigraphy, USG, and combined techniques were 85.3%, 72.5% and 90.4%, respectively; the positive predictive values (PPV) were 89.7%, 85.2%, and 92.6%, respectively. The most successful approach for detection of enlarged parathyroid glands in hyperparathyroidism is the concurrent application of USG and MIBI parathyroid scintigraphy modalities. The concomitance of thyroid diseases decreases the sensitivity of both MIBI parathyroid scintigraphy and USG in enlarged parathyroid glands

Increased mean platelet volume is associated with coronary artery ectasia

AIM: The present study was designed to investigate mean platelet volume (MPV) values in coronary artery ectasia (CAE) patients in comparison with individuals with coronary artery disease and normal coronary angiograms. MATERIAL AND METHODS: Patients with stable angina pectoris and scheduled for angiography were included in the study. Those with isolated coronary ectasia were evaluated in the coronary angiography. Mean platelet volume was measured in 126 patients (mean age: 57.2 ±11.3 years) with isolated CAE, 126 patients (mean age: 56.3 ±10.4 years) with coronary artery disease (CAD) and 122 control subjects (mean age: 58.1 ±11.1 years). Coronary artery ectasia was defined as lack of stenotic lesion, on visual assessment, of the coronary arteries with a luminal dilatation 1.5-fold or more of the adjacent normal coronary segments. Mean platelet volume values were recorded in all patients. Ectasia severity was evaluated and categorized in accordance with the Markis categorization. RESULTS: A significant difference with respect to age, sex, hypertension, diabetes mellitus, and cigarette use between the study groups was not found (p > 0.05). Mean platelet volume was significantly higher in patients with CAE and CAD than in the control group (9.8 ±3.8 fl and 9.7 ±3.9 fl vs. 8.8 ±3.3 fl, p < 0.001). There were no statistically significant differences between CAE and CAD groups. When type I and type IV subgroups were compared in patients with coronary artery ectasia, MPV was detected as statistically high in the type I subgroup (p = 0.026). CONCLUSIONS: It was shown that patients with CAE and CAD have higher MPVs than subjects with normal coronary angiograms. Moreover, it was detected that in coronary artery ectasias, the increase in MPV is related to both the atherosclerotic process and severity of the disease