4 research outputs found
Activity of grindelanes against important maize pest Spodoptera frugiperda and their selectivity of action on non-target environmental bacteria
In the search for new plant-derived products with antifeedant and insecticidal potential against economically important insects, 11 grindelanes (two as natural acids and nine as methylated derivatives) purified from the foliar tissue of Grindelia chiloensis (Cornel.) Cabrera (Asteraceae) were evaluated against the fall armyworm, Spodoptera frugiperda (JE Smith) (Lepidoptera: Noctuidae). Larvae of this moth are considered to be the main pest of maize that causes severe losses on local agricultural production. Remarkable alterations in feeding behavior, larval weight, larval and pupal stage lengths, and adult fertility, as well as malformations and mortality in specimens during their life cycle were noticed in the feeding preference tests and no-choice diet assays. Antifeedant indexes (AI%) calculated in food preference bioassays reached up to 79% for the lipophilic grindelane 3b, the most potent antifeedant agent. Grindelane 7b showed a better insecticidal activity (median lethal dose, LD50 = 26.49 ”g gâ1) and 8b was potentially neurotoxic due to acetylcholinesterase inhibition. Ultrastructure of the middle portion of the digestive tract of larvae fed with small amounts of natural grindelane 9a supplemented to the diet revealed cell damage, and thickening of the peritrophic membrane and a striking number of mitochondria, as evident signs of defense against toxic substances ingested by the larvae. Besides, this study demonstrated that these effective insecticides did not have inhibitory effects on beneficial plant and soil bacteria which would allow ecological pest management.Fil: Mesurado, MarĂa de Los Angeles. Universidad Nacional de TucumĂĄn. Facultad de BioquĂmica, QuĂmica y Farmacia. Instituto de QuĂmica OrgĂĄnica; ArgentinaFil: Chalup, Adriana Elizabeth. FundaciĂłn Miguel Lillo. DirecciĂłn de ZoologĂa. Instituto de EntomologĂa; ArgentinaFil: Ortiz, Javier Esteban. Universidad Nacional de San Juan. Facultad de IngenierĂa. Instituto de BiotecnologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - San Juan; ArgentinaFil: Zaragoza Puchol, JosĂ© Daniel. Universidad Nacional de San Juan. Facultad de IngenierĂa. Instituto de BiotecnologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - San Juan; ArgentinaFil: Feresin, Gabriela Egly. Universidad Nacional de San Juan. Facultad de IngenierĂa. Instituto de BiotecnologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - San Juan; ArgentinaFil: Bardon, Alicia del Valle. Universidad Nacional de TucumĂĄn. Facultad de BioquĂmica, QuĂmica y Farmacia. Instituto de QuĂmica OrgĂĄnica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Cartagena, Elena. Universidad Nacional de TucumĂĄn. Facultad de BioquĂmica, QuĂmica y Farmacia; Argentina. Universidad Nacional de TucumĂĄn. Instituto de BiotecnologĂa FarmacĂ©utica y Alimentaria. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - TucumĂĄn. Instituto de BiotecnologĂa FarmacĂ©utica y Alimentaria; Argentin
A new depigmenting-antifungal methylated grindelane from Grindelia chiloensis
The new methylated grindelane diterpenoid, 7ÎČâhydroxyâ8(17)âdehydrogrindelic acid (1b), together with the known 7αâhydroxyâ8(17)âdehydrogrindelic acid (2a), 6âoxogrindelic acid (3a), 4ÎČâhydroxyâ6âoxoâ19ânorgrindelic (4a), 19âhydroxygrindelic acid (5a), 18âhydroxygrindelic acid (6a), 4αâcarboxygrindelic acid (7a), 17âhydroxygrindelic acid (8a), 6αâhydroxygrindelic acid (9a), 8,17âbisnorâ8âoxagrindelic acid (10a), 7α,8αâepoxygrindelic acid (11a), and strictanonic acid (12a) as methyl esters were obtained from an Argentine collection of Grindelia chiloensis (Cornel.) Cabrera. Their structures and relative configurations were established on the basis of spectroscopic analysis. CHCl3 extract from the aerial parts and their pure compounds were evaluated for their antifungal and depigmenting effects. Methyl ester derivative of 10a (10b) exhibited a remarkable mycelial growth inhibition against Botritis cinerea with an IC50 of 13.5 ÎŒg mlâ1. While the new grindelane 1b exerted a clear color reduction of the yellowâorange pigment developed by Fusarium oxysporum against UVâinduced damage.Fil: Mesurado, Maria de los Angeles. Universidad Nacional de TucumĂĄn. Facultad de BioquĂmica, QuĂmica y Farmacia. Instituto de QuĂmica OrgĂĄnica; ArgentinaFil: Arias CassarĂĄ, MarĂa Lucrecia. Universidad Nacional de TucumĂĄn. Facultad de BioquĂmica, QuĂmica y Farmacia. Instituto de QuĂmica OrgĂĄnica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Misico, Rosana Isabel. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Ciudad Universitaria. Unidad de MicroanĂĄlisis y MĂ©todos FĂsicos en QuĂmica OrgĂĄnica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de MicroanĂĄlisis y MĂ©todos FĂsicos en QuĂmica OrgĂĄnica; ArgentinaFil: Bardon, Alicia del Valle. Universidad Nacional de TucumĂĄn. Facultad de BioquĂmica, QuĂmica y Farmacia. Instituto de QuĂmica OrgĂĄnica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Ybarra, MarĂa InĂ©s. Universidad Nacional de TucumĂĄn. Facultad de BioquĂmica, QuĂmica y Farmacia. Instituto de QuĂmica OrgĂĄnica; ArgentinaFil: Cartagena, Elena. Universidad Nacional de TucumĂĄn. Facultad de BioquĂmica, QuĂmica y Farmacia. Instituto de QuĂmica OrgĂĄnica; Argentin
PrĂĄcticas de laboratorio: QuĂmica orgĂĄnica
Fil: Schabes, Fanny Isabel. Universidad Nacional de TucumĂĄn. Facultad de BioquĂmica, QuĂmica y Farmacia; ArgentinaFil: Coronel, Angelina del Carmen. Universidad Nacional de TucumĂĄn. Facultad de BioquĂmica, QuĂmica y Farmacia; ArgentinaFil: Mesurado, MarĂa de Los Angeles. Universidad Nacional de TucumĂĄn. Facultad de BioquĂmica, QuĂmica y Farmacia; ArgentinaFil: Arias CassarĂĄ, MarĂa Lucrecia. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad Nacional de TucumĂĄn. Facultad de BioquĂmica, QuĂmica y Farmacia; ArgentinaFil: Torres, Andrea Carolina. Universidad Nacional de TucumĂĄn. Facultad de BioquĂmica, QuĂmica y Farmacia; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - TucumĂĄn. Centro de Referencia para Lactobacilos; ArgentinaFil: Beverina, Mariana. Universidad Nacional de TucumĂĄn. Facultad de BioquĂmica, QuĂmica y Farmacia; Argentin
A new depigmenting-antifungal methylated grindelane from Grindelia chiloensis
The new methylated grindelane diterpenoid, 7ÎČâhydroxyâ8(17)âdehydrogrindelic acid (1b), together with the known 7αâhydroxyâ8(17)âdehydrogrindelic acid (2a), 6âoxogrindelic acid (3a), 4ÎČâhydroxyâ6âoxoâ19ânorgrindelic (4a), 19âhydroxygrindelic acid (5a), 18âhydroxygrindelic acid (6a), 4αâcarboxygrindelic acid (7a), 17âhydroxygrindelic acid (8a), 6αâhydroxygrindelic acid (9a), 8,17âbisnorâ8âoxagrindelic acid (10a), 7α,8αâepoxygrindelic acid (11a), and strictanonic acid (12a) as methyl esters were obtained from an Argentine collection of Grindelia chiloensis (Cornel.) Cabrera. Their structures and relative configurations were established on the basis of spectroscopic analysis. CHCl3 extract from the aerial parts and their pure compounds were evaluated for their antifungal and depigmenting effects. Methyl ester derivative of 10a (10b) exhibited a remarkable mycelial growth inhibition against Botritis cinerea with an IC50 of 13.5 ÎŒg mlâ1. While the new grindelane 1b exerted a clear color reduction of the yellowâorange pigment developed by Fusarium oxysporum against UVâinduced damage.Fil: Mesurado, Maria de los Angeles. Universidad Nacional de TucumĂĄn. Facultad de BioquĂmica, QuĂmica y Farmacia. Instituto de QuĂmica OrgĂĄnica; ArgentinaFil: Arias CassarĂĄ, MarĂa Lucrecia. Universidad Nacional de TucumĂĄn. Facultad de BioquĂmica, QuĂmica y Farmacia. Instituto de QuĂmica OrgĂĄnica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Misico, Rosana Isabel. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Ciudad Universitaria. Unidad de MicroanĂĄlisis y MĂ©todos FĂsicos en QuĂmica OrgĂĄnica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de MicroanĂĄlisis y MĂ©todos FĂsicos en QuĂmica OrgĂĄnica; ArgentinaFil: Bardon, Alicia del Valle. Universidad Nacional de TucumĂĄn. Facultad de BioquĂmica, QuĂmica y Farmacia. Instituto de QuĂmica OrgĂĄnica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Ybarra, MarĂa InĂ©s. Universidad Nacional de TucumĂĄn. Facultad de BioquĂmica, QuĂmica y Farmacia. Instituto de QuĂmica OrgĂĄnica; ArgentinaFil: Cartagena, Elena. Universidad Nacional de TucumĂĄn. Facultad de BioquĂmica, QuĂmica y Farmacia. Instituto de QuĂmica OrgĂĄnica; Argentin