The stoichiometry and kinetics of biological heat generation in the aerobic stage of dual digestion

Over the past 10 years the Water Research Commission (WRC) has recognized the potential benefits of the dual digestion system for South Africa where anaerobic digestion is the preferred method of sludge stabilization. Accordingly, from 1981 to 1984 under WRC sponsorship, the Johannesburg City Council (JCC) undertook a pilot plant study into the performance of the autothermal thermophilic aerobic reactor oxygenated with pure oxygen. As a consequence of the encouraging results obtained in this study (Trim and McGlashan, 1984; Trim, 1984), in 1987 the WRC and Milnerton Municipality supported a frill scale evaluation of dual digestion ( 45 ma pure oxygen oxygenated aerobic reactor and 600 ma anaerobic digestor) at Milnerton's Potsdam Wastewater Treatment Works, with scientific and academic input by the Division of Water Technology of the CSIR and the Department of Civil Engineering, of UCT. In this evaluation a number of important considerations needed to be addressed such as (1) oxygen requirements and oxygen utilization efficiency with pure oxygen and air oxygenation, (2) minimum retention time that can be achieved in the aerobic reactor and in the anaerobic digestor without comprormsmg the attainment of thermophilic temperature in the reactor and VS removal, gas production and sludge stability in the digestor, (3) temperature control of the aerobic reactor and anaerobic digestor, ( 4) efficacy of pathogen inactivation and mode of operation to prevent recontamination, (5) dewaterability of the anaerobically digested sludge, (6) operation and economic evaluation of the system. In this thesis, the results obtained pertaining to operation and performance of the Milnerton aerobic reactor are presented in detail. Also, the observed results are generalized and, based on the observed general principles, a design procedure and a simulation algorithm and computer programme for pure oxygen and air oxygenated reactors are developed, in accordance with objectives (1) to (3) above

Installation of insecticide-treated durable wall lining: evaluation of attachment materials and product durability under field conditions.

BACKGROUND: Insecticide-treated durable wall lining (DL) is a new method of vector control designed to supplement LLINs and overcome two inherent limitations of LLINs and IRS: nightly behavioural compliance and short residual activity, respectively. DL is a deltamethrin-treated polyethylene material, which when used to cover interior house walls, functions as long-lasting IRS. Because the DL concept anticipates minimal upkeep, a primary challenge is how to guarantee correct household installation and in situ longevity for several years. Field trials were undertaken on various wall surfaces in Ghana to identify a logistically feasible, durable and re-usable method for DL wall attachment and to pilot new methods for assessing DL durability. METHODS: Over fifty-five candidate attachment or fixing products, including mechanical fasteners, material anchors and adhesives, were evaluated for their ability to tolerate static loads (simulating long-term installation) and short-term heavy weights (imitating shock damage). Attachment products were also scored using qualitative logistical and feasibility criteria, including ease of preparation, grip of fixing to DL and possibility of re-use. RESULTS: The stress tests provided a standardised, reproducible and reliable system for assessing fixing effectiveness and DL durability, with 64% (14/22) of adhesives and 15% (2/13) of mechanical fasteners failing to meet the minimum requirements of attaching DL to mud walls for set time periods. For most fixings, less outward load (0.2-8.0 kg) was required to detach DL from the wall, compared to downward load (0.2-19.2 kg). Fixings were better able to grip DL onto concrete than clay surfaces. Using a plastic nail cap to increase DL attachment area greatly improved grip and outward load tolerance, more so than varying nail size, length or texture. CONCLUSIONS: Based on a series of systematic stress tests, optimized fixing products for polyethylene DL wall attachment were identified. In parallel, a detailed and adaptable method of DL household installation was developed for routine deployment in malaria endemic areas. These standardized stress tests will form the basis for comparative evaluations of new types of DL textile, which incorporate non-pyrethroid insecticides to control malaria transmitted by resistant mosquito populations

Discovery of Brownleeite: a New Manganese Silicide Mineral in an Interplanetary Dust Particle

The Earth accretes approximately 40,000 tons of cosmic dust annually, originating mainly from the disintegration of comets and collisions among asteroids. This cosmic dust, also known as interplanetary dust particles (IDPs), is a subject of intense interest since it is made of the original building blocks of our Solar System. Although the specific parent bodies of IDPs are unknown, the anhydrous chondritic-porous IDPs (CP-IDPs) subset has been potentially linked to a cometary source. The CP-IDPs are extremely primitive materials based on their unequilibrated mineralogy, C-rich chemistry, and anomalous isotopic signatures. In particular, some CP-IDPs escaped the thermal, aqueous and impact shock processing that has modified or destroyed the original mineralogy of meteorites. Thus, the CP-IDPs represent some of the most primitive solar system materials available for laboratory study. Most CP-IDPs are comprised of minerals that are common on Earth. However, in the course of an examination of one of the CP-IDPs, we encountered three sub-micrometer sized grains of manganese silicide (MnSi), a phase that has heretofore not been found in nature. In the seminar, we would like to focus on IDP studies and this manganese silicide phase that has been approved as the first new mineral identified from a comet by the International Mineralogical Association (IMA) in 2008. The mineral is named in honour of Donald E. Brownlee, an American astronomer and a founder of the field of cosmic dust research who is the principal investigator of the NASA Stardust Mission that collected dust samples from Comet 81P/Wild-2 and returned them to Earth. Much of our current view and understanding of the early solar system would not exist without the pioneering work of professor Don Brownlee in the study of IDPs

Nested sampling with normalizing flows for gravitational-wave inference

We present a novel method for sampling iso-likelihood contours in nested sampling using a type of machine learning algorithm known as normalizing flows and incorporate it into our sampler nessai. nessai is designed for problems where computing the likelihood is computationally expensive and therefore the cost of training a normalizing flow is offset by the overall reduction in the number of likelihood evaluations. We validate our sampler on 128 simulated gravitational wave signals from compact binary coalescence and show that it produces unbiased estimates of the system parameters. Subsequently, we compare our results to those obtained with dynesty and find good agreement between the computed log-evidences while requiring 2.07 times fewer likelihood evaluations. We also highlight how the likelihood evaluation can be parallelized in nessai without any modifications to the algorithm. Finally, we outline diagnostics included in nessai and how these can be used to tune the sampler’s settings

Importance nested sampling with normalising flows

We present an improved version of the nested sampling algorithm nessai in which the core algorithm is modified to use importance weights. In the modified algorithm, samples are drawn from a mixture of normalising flows and the requirement for samples to be independently and identically distributed (i.i.d.) according to the prior is relaxed. Furthermore, it allows for samples to be added in any order, independently of a likelihood constraint, and for the evidence to be updated with batches of samples. We call the modified algorithm i-nessai. We first validate i-nessai using analytic likelihoods with known Bayesian evidences and show that the evidence estimates are unbiased in up to 32 dimensions. We compare i-nessai to standard nessai for the analytic likelihoods and the Rosenbrock likelihood, the results show that i-nessai is consistent with nessai whilst producing more precise evidence estimates. We then test i-nessai on 64 simulated gravitational-wave signals from binary black hole coalescence and show that it produces unbiased estimates of the parameters. We compare our results to those obtained using standard nessai and dynesty and find that i-nessai requires 2.68 and 13.3 times fewer likelihood evaluations to converge, respectively. We also test i-nessai of an 80-second simulated binary neutron star signal using a Reduced-Order-Quadrature (ROQ) basis and find that, on average, it converges in 24 minutes, whilst only requiring 1.01 × 106 likelihood evaluations compared to 1.42 × 106 for nessai and 4.30 × 107 for dynesty. These results demonstrate the i-nessai is consistent with nessai and dynesty whilst also being more efficient

The Greening of Pesticide–Environment Interactions: Some Personal Observations

Background: Pesticide–environment interactions are bidirectional. The environment alters pesticides by metabolism and photodegradation, and pesticides in turn change the environment through nontarget or secondary effects

Percutaneous Coronary Intervention and Drug-Eluting Stent Use Among Patients ≥85 Years of Age in the United States

ObjectivesThis study assessed the comparative effectiveness of drug-eluting stents (DES) versus bare-metal stents (BMS) among patients ≥85 years of age.BackgroundDespite an aging population, little is known about the comparative effectiveness of DES versus BMS among patients age ≥85 years undergoing percutaneous coronary intervention (PCI).MethodsWe examined 471,006 PCI patients age ≥65 years at 947 hospitals in the National Cardiovascular Data Registry between 2004 and 2008 and linked to Medicare claims data. Long-term outcomes (median follow-up 640.8 ± 423.5 days) were compared between users of DES and BMS.ResultsPatients age ≥85 years comprise an increasing proportion of PCIs performed among elderly subjects, yet rates of DES use declined the most in this age group. Compared with BMS, use of DES was associated with lower mortality: age ≥85 years, 29% versus 38% (adjusted hazard ratio [HR]: 0.80 [95% confidence interval (CI): 0.77 to 0.83]); age 75 to 84 years, 17% versus 25% (HR: 0.77 [95% CI: 0.75 to 0.79]); and age 65 to 74 years, 10% versus 16% (HR: 0.73 [95% CI: 0.71 to 0.75]). However, the adjusted mortality difference narrowed with increasing age (pinteraction <0.001). In contrast, the adjusted HR for myocardial infarction rehospitalization associated with DES use was significantly lower with increasing age: age ≥85 years, 9% versus 12% (HR: 0.77 [95% CI: 0.71 to 0.83]); age 75 to 84 years, 7% versus 9% (HR: 0.81 [95% CI: 0.77 to 0.84]); and age 65 to 74 years, 7% versus 8% (HR: 0.84 [95% CI: 0.80 to 0.88]) (pinteraction <0.001).ConclusionsIn this national study of older patients undergoing PCI, declines in DES use were most pronounced among those aged ≥85 years, yet lower adverse-event rates associated with DES versus BMS use were observed