5 research outputs found
Exploring the world of non-coding genes in stem cells and autoimmunity.
Numerous
studies have contributed to our current understanding of autoimmune diseases
(AIDs), however, pathogenesis of many AIDs can still not be fully explained.
Both genetic factors and environmental factors are involved in the onset of
autoimmunity. Which mechanisms explain the contribution of these genetic and
environmental factors to disease pathogenesis, and how the different factors
interplay remain unanswered key questions. The studies presented in this thesis
aimed at identifying and unravelling some of the enigmatic mechanisms in
rheumatoid arthritis (RA) and systemic sclerosis (SSc). LUMC / Geneeskund
Inflammatory genes TNFα and IL6 display no signs of increased H3K4me3 in circulating monocytes from untreated rheumatoid arthritis patients
Pathophysiology and treatment of rheumatic disease
Radiofrequency ablation versus hepatic resection for hepatocellular carcinoma within the Milan criteria – A comparative study
AbstractBackgroundTo compare the results of radiofrequency ablation (RFA) with hepatic resection in the treatment of hepatocellular carcinoma (HCC) within the Milan criteria.MethodsA nonrandomized comparative study was performed with 111 consecutive patients who underwent laparoscopic RFA (n = 31) or curative hepatic resection (n = 80) for HCC within Milan criteria.ResultsProcedure related complications were less often and severe after RFA than resection (3.2% vs. 25%). There was no significant difference in hospital mortality (0% vs. 3.8%). Hospital stay was significantly shorter in the RFA group than in the resection group (mean, 3.8 vs. 6.8 days). The 1-, 3-, and 5-year disease-free survival rates for the RFA group and the resection group were 76%, 40%, 40% and 76%, 60%, 60%, respectively. Disease-free survival was significantly lower in the RFA group than in the resection group. The corresponding 1-, 3-, and 5-year overall survival rates for the RFA group and the resection group were 100%, 92%, 84%, and 92%, 75%, 71%, respectively. The overall survival for RFA and resection were not significantly different.ConclusionsOur result showed comparable overall survival between RFA and surgery, although RFA was associated with a significantly higher tumor recurrence rate. RFA had the advantages over surgical resection in being less invasive and having lower morbidity
Immunogenetics of rheumatoid arthritis: Understanding functional implications
Pathophysiology and treatment of rheumatic disease