Feasibility and reliability of on-line automated microemboli detection after carotid endarterectomy. A transcranial Doppler study

AbstractObjectives: recently, a new algorithm for transcranial Doppler (TCD) ultrasound detection of microembolic signals (MES) was developed. In the present study, we investigated its on-line performance in TCD monitoring after carotid endarterectomy (CEA) and assessed off-line its accuracy in detecting MES. Materials and Methods: first, the feasibility of MES detection in TCD monitoring after CEA in a routine clinical setting was evaluated in 50 patients. Second, to test the reliability of the software a 2-h digital audio study tape was made and analysed by the algorithm and five human experts. The “gold standard” was defined as the agreement between human experts: a MES was considered to be present if at least three human observers agreed. Results: TCD monitoring for emboli detection after CEA was well tolerated by the patients and could be performed reliably. In the study tape, the human gold standard detected 107 MES, with 93 MES having an intensity of ≥7 dB. The software detected 81 and 77 MES, respectively. Using the 7 dB intensity threshold, the software had no false positives and 16 false negatives. The κ value between the human gold standard and the software was 0.91, the proportion of specific agreement was 0.83. Conclusions: the tested algorithm provides a reliable method for automated on-line microemboli detection after CEA. This makes monitoring of the effectiveness of antiplatelet agents in the prevention of stroke after CEA more practicable.Eur J Vasc Endovasc Surg 25, 262–266 (2003

Diffusion due to the Beam-Beam Interaction and Fluctuating Fields in Hadron Colliders

Random fluctuations in the tune, beam offsets and beam size in the presence of the beam-beam interaction are shown to lead to significant particle diffusion and emittance growth in hadron colliders. We find that far from resonances high frequency noise causes the most diffusion while near resonances low frequency noise is responsible for the large emittance growth observed. Comparison of different fluctuations shows that offset fluctuations between the beams causes the largest diffusion for particles in the beam core.Comment: 5 pages, 3 postscript figure

Geometry and observables in (2+1)-gravity

We review the geometrical properties of vacuum spacetimes in (2+1)-gravity with vanishing cosmological constant. We explain how these spacetimes are characterised as quotients of their universal cover by holonomies. We explain how this description can be used to clarify the geometrical interpretation of the fundamental physical variables of the theory, holonomies and Wilson loops. In particular, we discuss the role of Wilson loop observables as the generators of the two fundamental transformations that change the geometry of (2+1)-spacetimes, grafting and earthquake. We explain how these variables can be determined from realistic measurements by an observer in the spacetime.Comment: Talk given at 2nd School and Workshop on Quantum Gravity and Quantum Geometry (Corfu, September 13-20 2009); 10 pages, 13 eps figure

The transcriptomic evolution of mammalian pregnancy:gene expression innovations in endometrial stromal fibroblasts

The endometrial stromal fibroblast (ESF) is a cell type present in the uterine lining of therian mammals. In the stem lineage of eutherian mammals, ESF acquired the ability to differentiate into decidual cells in order to allow embryo implantation. We call the latter cell type “neo-ESF” in contrast to “paleo-ESF” which is homologous to eutherian ESF but is not able to decidualize. In this study, we compare the transcriptomes of ESF from six therian species: Opossum (Monodelphis domestica; paleo-ESF), mink, rat, rabbit, human (all neo-ESF), and cow (secondarily nondecidualizing neo-ESF). We find evidence for strong stabilizing selection on transcriptome composition suggesting that the expression of approximately 5,600 genes is maintained by natural selection. The evolution of neo-ESF from paleo-ESF involved the following gene expression changes: Loss of expression of genes related to inflammation and immune response, lower expression of genes opposing tissue invasion, increased markers for proliferation as well as the recruitment of FOXM1, a key gene transiently expressed during decidualization. Signaling pathways also evolve rapidly and continue to evolve within eutherian lineages. In the bovine lineage, where invasiveness and decidualization were secondarily lost, we see a re-expression of genes found in opossum, most prominently WISP2, and a loss of gene expression related to angiogenesis. The data from this and previous studies support a scenario, where the proinflammatory paleo-ESF was reprogrammed to express anti-inflammatory genes in response to the inflammatory stimulus coming from the implanting conceptus and thus paving the way for extended, trans-cyclic gestation

Potential and mass-matrix in gauged N=4 supergravity

We discuss the potential and mass-matrix of gauged N=4 matter coupled supergravity for the case of six matter multiplets, extending previous work by considering the dependence on all scalars. We consider all semi-simple gauge groups and analyse the potential and its first and second derivatives in the origin of the scalar manifold. Although we find in a number of cases an extremum with a positive cosmological constant, these are not stable under fluctuations of all scalar fields.Comment: 28 pages, LaTe

Loop Representations for 2+1 Gravity on a Torus

We study the loop representation of the quantum theory for 2+1 dimensional general relativity on a manifold, $M = {\cal T}^2 \times {\cal R}$, where ${\cal T}^2$ is the torus, and compare it with the connection representation for this system. In particular, we look at the loop transform in the part of the phase space where the holonomies are boosts and study its kernel. This kernel is dense in the connection representation and the transform is not continuous with respect to the natural topologies, even in its domain of definition. Nonetheless, loop representations isomorphic to the connection representation corresponding to this part of the phase space can still be constructed if due care is taken. We present this construction but note that certain ambiguities remain; in particular, functions of loops cannot be uniquely associated with functions of connections.Comment: 24 journal or 52 preprint pages, revtex, SU-GP-93/3-

3-manifolds which are spacelike slices of flat spacetimes

We continue work initiated in a 1990 preprint of Mess giving a geometric parameterization of the moduli space of classical solutions to Einstein's equations in 2+1 dimensions with cosmological constant 0 or -1 (the case +1 has been worked out in the interim by the present author). In this paper we make a first step toward the 3+1-dimensional case by determining exactly which closed 3-manifolds M^3 arise as spacelike slices of flat spacetimes, and by finding all possible holonomy homomorphisms pi_1(M^3) to ISO(3,1).Comment: 10 page

Collisions of particles in locally AdS spacetimes II Moduli of globally hyperbolic spaces

We investigate 3-dimensional globally hyperbolic AdS manifolds containing "particles", i.e., cone singularities of angles less than $2\pi$ along a time-like graph $\Gamma$. To each such space we associate a graph and a finite family of pairs of hyperbolic surfaces with cone singularities. We show that this data is sufficient to recover the space locally (i.e., in the neighborhood of a fixed metric). This is a partial extension of a result of Mess for non-singular globally hyperbolic AdS manifolds.Comment: 29 pages, 3 figures. v2: 41 pages, improved exposition. To appear, Comm. Math. Phys. arXiv admin note: text overlap with arXiv:0905.182

Witten's 2+1 gravity on R x (Klein bottle)

Witten's formulation of 2+1 gravity is investigated on the nonorientable three-manifold R x (Klein bottle). The gauge group is taken to consist of all four components of the 2+1 Poincare group. We analyze in detail several components of the classical solution space, and we show that from four of the components one can recover nondegenerate spacetime metrics. In particular, from one component we recover metrics for which the Klein bottles are spacelike. An action principle is formulated for bundles satisfying a certain orientation compatibility property, and the corresponding components of the classical solution space are promoted into a phase space. Avenues towards quantization are briefly discussed.Comment: 33 pages, REVTeX v3.0, 3 figures in a separate PostScript fil

Uniqueness of de Sitter space

All inextendible null geodesics in four dimensional de Sitter space dS^4 are complete and globally achronal. This achronality is related to the fact that all observer horizons in dS^4 are eternal, i.e. extend from future infinity scri^+ all the way back to past infinity scri^-. We show that the property of having a null line (inextendible achronal null geodesic) that extends from scri^- to scri^+ characterizes dS^4 among all globally hyperbolic and asymptotically de Sitter spacetimes satisfying the vacuum Einstein equations with positive cosmological constant. This result is then further extended to allow for a class of matter models that includes perfect fluids.Comment: 22 pages, 2 figure