7 research outputs found
Expression of cytotoxic T lymphocyte-associated antigen 4, CD44, and E-cadherin in the microenvironment of breast carcinomas
OBJECTIVE: The expression of cytotoxic T lymphocyte-associated antigen 4, E-cadherin, and CD44 in the area of tumor budding was investigated in breast carcinomas in our study. METHODS: Tumor budding was counted at the invasive margins in 179 breast carcinomas. To understand the microenvironment of tumor budding, we examined the expression status of the immune checkpoint molecules such as cytotoxic T lymphocyte-associated antigen 4, E-cadherin, and CD44. RESULTS: Tumors were separated into low (≤5) and high tumor budding groups (>5) based on the median budding number. Lymphovascular, perineural invasion, and the number of metastatic lymph nodes were significantly higher in high-grade budding tumors (p=0.001, p<0.001, and p=0.019, respectively). Tumor-infiltrating lymphocytes were significantly higher in tumors without tumor buddings (p[removed
The Quality of Life Measurements Following Oncoplastic Breast-conserving Surgery
Objective:Oncoplastic breast-conserving surgery (OBCS) is a widely accepted surgical option among breast cancer patients. We aimed to evaluate the histopathological findings of breast tumors and quality of life scores.Method:The clinical and pathological data of 49 female patients who underwent OBSC in University of Health Sciences Turkey, İstanbul Bağcılar Training and Research Hospital between January 2015 and January 2019 for breast cancer were retrospectively evaluated. According to the location of the tumor, the racket method or J-mammoplasty techniques was selected. Quality of life and patient satisfaction assessment questionnaire was performed.Results:The mean age was 48.1 (26-68) years. The most common incision pattern was the racket pattern (85%). The invasive ductal carcinoma (89.8%) was seen more than ductal carcinoma in situ (6.1%) and papillary carcinoma (4.1%). The distance to the surgical margin was approximately 7.1 mm (1-20). The estrogen receptor positivity was 74.2% (5-100%) and progesterone receptor positivity was 61.8% (5-98%). 61.2% received chemotherapy (100%, radiotherapy). Based on questionnaires, the score of quality of life and satisfaction was 34 (25-47). Especially, the body image function [22 (15-29)] and health functions [10 (7-13)], such as breast & arm symptoms, were better in the patients who had higher scores (p<0.001).Conclusion:The histopathological patterns of the patients following OBSC potentially did not show any impact among the quality of life and satisfaction scores
LAPAROSKOPIK BARIYATRIK CERRAHI ONCESI VE SONRASI DEMIR, TOTAL DEMIR BAGLAMA KAPASITESI VE FERRITIN SEVIYELERININ KARSILASTIRILMASI
Metastatik Kolorektal Kanserli Hastalarda Yaşam Kalitesine Etki Eden Parametrelerin Değerlendirilmesi
The Performance Analysis of the Thyroid Nodule Size to Predict the Coexistence of Micropapillary Carcinoma
Objective:Incidental micropapillary carcinoma (IMC) is the most common variant of thyroid malignancies. There are unmet needs regarding the efficacy of nodule size in the prediction of the coexistence of IMC. We aimed to measure the effect of nodule size on the prediction of the coexistence of IMC.Method:The data of 194 patients who underwent biopsy for fine-needle aspiration cytology and subsequent thyroidectomy in a research and training hospital between January 2017 and February 2020 were analyzed retrospectively. The patients were divided into three groups according to the sizes of thyroid nodules as 0-10 mm, 11-20 mm, and >20 mm. Logistic regression analysis was performed.Results:The patients with nodule size between 0 mm and 10 mm mostly showed hypothyroidism (51.0% vs. 28.8% vs. 41.8%) while patients with size between 11 mm and 20 mm mostly had euthyroidism (44.2% vs. 45.1% vs. 41.8%, p=0.0175). Both malignancy (51.9% vs. 49.0% vs. 42.9%, p=0.544) and IMC (65.4% vs. 51.0% vs. 56.0%, p=0.32) were observed more likely in patients with moderate size (11-20 mm). We found the following variables to be predictors for the coexistence of IMC: absence of halo [odds ratio (OR): 4.50, 95% confidence interval (CI): 1.61-14.71, p=0.007], and interestingly decrease in vascularity [OR: 0.33, 95% CI: 0.12-0.87, p=0.030], and total thyroidectomy, [OR: 4.55, 95% CI: 2.30- 9.56, p2 cm), we reported more IMC inside the thyroid gland. However, the nodule size has the low performance to be a predictor for the coexistence of IMC in the thyroid gland