Sir C. Wyville Thomson\u27s letters to staff-commander Thomas H. Tizard, 1877-1881

These original letters from Thomson to Tizard are concerned with the publication of the results of the CHALLENGER Expedition, as well as the study of the Faroe Channel and the eventual delineation of the Wyville Thomson Ridge with its diversity of cold and warm area bottom fauna. They also provide evidence of Thomson\u27s indefatigability as well as certain historical sidelights

A posse ad esse

From possibility to reality seems an appropriate phrase to describe the development of oceanography in the pa.st three-quarters of a century. It is of little more than academic interest to pick a particular date or event as marking the birth of a field of endeavor; however, for oceanography, the late 1860\u27s and the early 1870\u27s unquestionably mark the period which gave the greatest impetus to research on the chemistry, physics a.nd biology of the sea...

An appreciation and Statement of policy

With this issue, Volume XXXII, number 1, of the Journal of Marine Research, we have a new Editor, George Veronis, Professor of Geophysics and Applied Science…

Volume 9. Article 4. Studies on the marine resources of southern New England. IV. The biology and economic importance of the ocean pout, Macrozoarces americanus (Bloch and Schneider).

https://elischolar.library.yale.edu/bulletin_yale_bingham_oceanographic_collection/1134/thumbnail.jp

Volume 9. Article 2. Studies on the marine resources of southern New England. I. An analysis of the fish population of the shore zone.

https://elischolar.library.yale.edu/bulletin_yale_bingham_oceanographic_collection/1132/thumbnail.jp

Volume 13. Article 3. Hydrographic and biological studies of Block Island Sound.

https://elischolar.library.yale.edu/bulletin_yale_bingham_oceanographic_collection/1150/thumbnail.jp

Volume 18. Article 3. Studies on two skates: Raja erinacea Mitchill, Raja eglanteria Bosc.

https://elischolar.library.yale.edu/bulletin_yale_bingham_oceanographic_collection/1164/thumbnail.jp

Support for UNRWA's survival

The United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA) provides life-saving humanitarian aid for 5·4 million Palestine refugees now entering their eighth decade of statelessness and conflict. About a third of Palestine refugees still live in 58 recognised camps. UNRWA operates 702 schools and 144 health centres, some of which are affected by the ongoing humanitarian disasters in Syria and the Gaza Strip. It has dramatically reduced the prevalence of infectious diseases, mortality, and illiteracy. Its social services include rebuilding infrastructure and homes that have been destroyed by conflict and providing cash assistance and micro-finance loans for Palestinians whose rights are curtailed and who are denied the right of return to their homeland

Improving the efficiency of genomic loci capture using oligonucleotide arrays for high throughput resequencing

<p>Abstract</p> <p>Background</p> <p>The emergence of next-generation sequencing technology presents tremendous opportunities to accelerate the discovery of rare variants or mutations that underlie human genetic disorders. Although the complete sequencing of the affected individuals' genomes would be the most powerful approach to finding such variants, the cost of such efforts make it impractical for routine use in disease gene research. In cases where candidate genes or loci can be defined by linkage, association, or phenotypic studies, the practical sequencing target can be made much smaller than the whole genome, and it becomes critical to have capture methods that can be used to purify the desired portion of the genome for shotgun short-read sequencing without biasing allelic representation or coverage. One major approach is array-based capture which relies on the ability to create a custom in-situ synthesized oligonucleotide microarray for use as a collection of hybridization capture probes. This approach is being used by our group and others routinely and we are continuing to improve its performance.</p> <p>Results</p> <p>Here, we provide a complete protocol optimized for large aggregate sequence intervals and demonstrate its utility with the capture of all predicted amino acid coding sequence from 3,038 human genes using 241,700 60-mer oligonucleotides. Further, we demonstrate two techniques by which the efficiency of the capture can be increased: by introducing a step to block cross hybridization mediated by common adapter sequences used in sequencing library construction, and by repeating the hybridization capture step. These improvements can boost the targeting efficiency to the point where over 85% of the mapped sequence reads fall within 100 bases of the targeted regions.</p> <p>Conclusions</p> <p>The complete protocol introduced in this paper enables researchers to perform practical capture experiments, and includes two novel methods for increasing the targeting efficiency. Coupled with the new massively parallel sequencing technologies, this provides a powerful approach to identifying disease-causing genetic variants that can be localized within the genome by traditional methods.</p