30 research outputs found
A new collaborative model of primary care research:could it provide trainees and clinicians with more opportunities to get involved?
Predicting prostate cancer progression:protocol for a retrospective cohort study to identify prognostic factors for prostate cancer outcomes using routine primary care data
IntroductionProstate cancer is the most common cancer in men in the UK, with nearly 40 000 diagnosed in 2014; and it is the second most common cause of male cancer-related mortality. The clinical conundrum is that most men live with prostate cancer rather than die from it, while existing treatments have significant associated morbidity. Recent studies have shown very low mortality rates (1% after a median of 10-year follow-up) and no treatment-related reductions in mortality, in men with localised prostate cancer. This study will identify prognostic factors associated with prostate cancer progression to help differentiate aggressive from more indolent tumours in men with localised disease at diagnosis, and so inform the decision to adopt conservative (active surveillance) or radical (surgery or radiotherapy) management strategies.Methods and analysisThe Clinical Practice Research Datalink (CPRD) contains 57 318 men who were diagnosed with prostate cancer between 1 January 1987 and 31 December 2016. These men will be linked to the Office for National Statistics (ONS) and the National Cancer Registration and Analysis Service registry databases for mortality, TNM stage, Gleason grade and treatment data. Men with a diagnosis date prior to 1 January 1987 and men with lymph node or distant metastases at diagnosis will be excluded. A priori determined prognostic factors potentially associated with prostate cancer mortality, the end point of cancer progression, will be measured at baseline, and the participants followed through to development of cancer progression, death or the end of the follow-up period (31 December 2016). Cox proportional hazards regression will be used to estimate crude and mutually adjusted HRs. Mortality risk will be predicted using flexible parametric survival models that can accurately fit the shape of the hazard function.Ethics and disseminationThis study protocol has approval from the Independent Scientific Advisory Committee for the UK Medicines and Healthcare products Regulatory Agency Database Research (protocol 17_041). The findings will be presented in peer-reviewed journals and local CPRD researcher meetings.</jats:sec
Predicting prostate cancer progression:protocol for a retrospective cohort study to identify prognostic factors for prostate cancer outcomes using routine primary care data
Graphic representation of publication bias using funnel plots of all included studies. (DOCX 1318 kb
Developing a communication toolbox for primary care practitioners to raise the issue of weight with parents of preschool children:a qualitative study
Why test study protocol: a UK-wide audit using the Primary Care Academic Collaborative to explore the reasons for primary care testing
Why test study protocol: a UK-wide audit using the primary care academic collaborative to explore the reasons for primary care testing
This is the author accepted manuscript. The final version is available on open access from the Royal College of General Practitioners via the DOI in this recordBackground
The number of blood tests done in primary care has been increasing over the last 20 years. Some
estimates suggest that up to a quarter of these tests may not have been needed. This could lead to a
cascade effect of further investigations, appointments, or referrals, as well as anxiety for patients,
increased workload and costs to the health service. To better understand the impact and sequelae of
blood tests on patients, we need to know why blood tests are requested and what is done with the
results.
Aims
To explore who orders blood tests and why, and how test results are actioned in primary care.
Design & Setting
Retrospective audit of electronic health records in general practices across the UK.
Method
The Primary care Academic CollaboraTive (PACT), a UK-wide network of primary care health
professionals, will be utilised to collect data from individual practices. PACT members will be asked
to review the electronic health records of 50 patients who had recent blood tests in their practice,
and manually extract anonymised data on who requested the test, the indication, the result, and
subsequent actions. Data will also be collected from PACT members to assess the feasibility of the
collaborative model.
Conclusion
PACT offers a unique opportunity to extract clinical data which cannot otherwise be obtained.
Understanding the indications for tests will help identify priority areas for research to optimise
testing and patient safety in primary care.Bristol, North Somerset and South Gloucestershire Clinical Commissioning Grou
Validation of the National Cancer Registration and Analysis Service (NCRAS) prostate cancer registry with data from the CAP study
Cross-sectional study evaluating data quality of the National Cancer Registration and Analysis Service (NCRAS) prostate cancer registry data using the Cluster randomised trial of PSA testing for Prostate cancer (CAP)
ObjectivesTo compare the completeness and agreement of prostate cancer data recorded by the National Cancer Registration and Analysis Service (NCRAS) with research-level data specifically abstracted from medical records from the Cluster randomised triAl of prostate specific antigen (PSA) testing for Prostate cancer (CAP) trial.DesignCross-sectional comparison study.ParticipantsWe included 1356 men from the CAP trial cohort who were linked to the NCRAS registry.Primary and secondary outcome measuresCompleteness of prostate cancer data in NCRAS and CAP and agreement for tumour, node, metastases (TNM) stage (T1/T2; T3; T4/N1/M1) and Gleason grade (4–6; 7; 8–10), measured by differences in proportions and Cohen’s kappa statistic. Data were also stratified by year and pre-2010 versus post-2010, when NCRAS reporting standards changed.ResultsCompared with CAP, completeness was lower in NCRAS for Gleason grade (41.2% vs 76.7%, difference 35.5, 95% CI 32.1 to 39.0) and TNM stage (29.9% vs 67.6%, difference 37.6, 95% CI 34.1 to 41.1). NCRAS completeness for Gleason grade (pre-2010 vs post-2010 31.69% vs 64%; difference 32.31, 95% CI 26.76 to 37.87) and TNM stage (19.31% vs 55.50%; difference 36.19, 95% CI 30.72 to 41.67) improved over time. Agreement for Gleason grade was high (Cohen’s kappa, κ=0.90, 95% CI 0.88 to 0.93), but lower for TNM stage (κ=0.41, 95% CI 0.37 to 0.51) overall. There was a trend towards improved agreement on Gleason grade, but not TNM stage, when comparing pre-2010 and post-2010 data.ConclusionNCRAS case identification was very high; however, data on prostate cancer grade was less complete than CAP, and agreement for TNM stage was modest. Although the completeness of NCRAS data has improved since 2010, the higher completeness rate in CAP demonstrates that gains could potentially be achieved in routine registry data. This study’s findings highlight a need for improved recording of stage and grade data in the source medical records.</jats:sec
Management of angina in primary care
Angina pectoris is chest pain due to insufficient coronary artery blood flow and/or increased myocardial oxygen demand. In 2012, angina affected 3.05% of men and 1.79% of women in the UK. Stable angina is a chronic disease that can progress to unstable angina or myocardial infarction. Lifestyle modification, medications, and cardiac intervention/cardiothoracic surgery all play a part in its management. Patients with angina are mostly managed in primary care, where the focus of care is on maintaining quality of life and preventing disease progression. </jats:p