Design and development of web application "flash cards"

Tato bakalářská práce je zaměřena na návrh a vývoj webové aplikace typu "flash cards", která bude sloužít jako pomůcka pro výuku a přípravu ke zkouškám. Kartička (flash čard) na jedné straně má pojem a na obrácené straně definice. V rámci dané práce byla provedena analýza existujících řešení a následné návrh a vývoj vlastního řešení. Výstupem této práce je webová aplikace, která umožňuje pracovat s kartičkami (flash cards) pro výuku.The Bachelor's thesis deals with design and development of the “Flash cards” type web application. The application is defined as a learning aid for studying and preparing for examinations. The flash card bears a question on the one side and an answer on the other. The thesis carries out an analysis of existing solutions and the subsequent design and development of the solution itself. The work output represents a web application allowing to work with flash cards for studying

An efficient conjugation approach for coupling drugs to native antibodies via the PtII linker Lx for improved manufacturability of antibody–drug conjugates

The Pt-II linker [ethylenediamineplatinum(II)](2+), coined Lx, has emerged as a novel non-conventional approach to antibody-drug conjugates (ADCs) and has shown its potential in preclinical in vitro and in vivo benchmark studies. A crucial improvement of the Lx conjugation reaction from initially <15 % to ca. 75-90 % conjugation efficiency is described, resulting from a systematic screening of all relevant reaction parameters. NaI, a strikingly simple inorganic salt additive, greatly improves the conjugation efficiency as well as the conjugation selectivity simply by exchanging the leaving chloride ligand on Cl-Lx-drug complexes (which are direct precursors for Lx-ADCs) for iodide, thus generating I-Lx-drug complexes as more reactive species. Using this iodide effect, we developed a general and highly practical conjugation procedure that is scalable: our lead Lx-ADC was produced on a 5 g scale with an outstanding conjugation efficiency of 89 %.Metals in Catalysis, Biomimetics & Inorganic Material

The effect of trees isolation on mossy pine forest growth when cutting trees of productivity classes IV and V

Due to the fact that there are still some contradictory viewpoints on the matter of increasing of forest total productivity by cleaning cuttings the given research has been done. The forest total productivity is made up of natural mortality as well as the volume of intermediate and final forest cuttings. It is impossible to indentify correctly the forest trees reaction of different productivity classes when a cleaning cutting has been carried out. Taking into account all facts mentioned above, a special permanent sample forest plot was laid in 1977 by the researchers of forest Silviculture department of the Belarusian State Technological University. The sample plot is represented by a 30-years pine mossy forest stand in Negoreloe experimental forestry enterprise. Based on the data from the permanent sample plot the cleaning cutting effect on productivity of pine mossy forest stands, and the process of their forming when one sampled and cut down trees of different productivity classes has been researched