Right atrial thrombus, junctional tachycardia, and critical lower limb ischemia: three rare complications of severe acute respiratory syndrome coronavirus 2 infection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can engender multi-system inflammatory syndrome. Its main symptoms are cardiovascular and thromboembolic problems that can develop into severe complications. The present case is about a 55-year-old patient who was admitted for critical ischemia of the right lower limb and necrosis of the right forefoot. The patient was infected with coronavirus disease 2019 (COVID-19) one month before her admission. The patient also has cardiovascular risks including type 2 diabetes and hypertension. The performance of ultrasounds revealed a thrombus in the right atrium and the pulmonary artery, and arteriography detected an occlusion of the right popliteal joint for which she had an endovascular recanalization and amputation of the right forefoot. This case highlights that SARS-CoV-2 infection could be considered a serious cardiovascular disease requiring cardiovascular explorations to initiate hospital management and avoid severe complications

Perceptions and sociocultural factors underlying adoption of conservation agriculture in the Mediterranean

The Mediterranean region is facing major challenges for soil conservation and sustainable agriculture. Conservation agriculture (CA), including reduced soil disturbance, can help conserve soils and improve soil fertility, but its adoption in the Mediterranean region is limited. Examining farmers’ perceptions of soil and underlying sociocultural factors can help shed light on adoption of soil management practices. In this paper, we conducted a survey with 590 farmers across Morocco, Spain and Tunisia to explore concepts that are cognitively associated with soil and perceptions of tillage. We also evaluated differences in perceptions of innovation, community, adaptive capacity, and responsibility for soil. We found that farmers’ cognitive associations with soil show awareness of soil as a living resource, go beyond agriculture and livelihoods to reveal cultural ties, and link to multiple levels of human needs. Beliefs about the benefits of tillage for water availability and yield persist among the surveyed farmers. We found that openness towards innovation, perceived adaptive capacity and responsibility for soil were associated with minimum tillage, whereas community integration was not. Education, age and farm lifestyle were also associated with differences in these perceptions. CA promotion in the Mediterranean should emphasize the multiple values of soil, should demonstrate how sufficient yields may be achieved alongside resilience to drought, and be tailored to differing levels of environmental awareness and economic needs across north and south

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely