Horn antenna with v-shaped corrugated surface

Corrugated shape is easily machined for millimeter wave application and is better suited for folding antenna designs. Measured performance showed ""V'' corrugations and rectangular corrugations have nearly the same pattern beamwidth, gain, and impedance. Also, ""V'' corrugations have higher relative power loss

Autophagy: an affair of the heart

Whether an element of routine housekeeping or in the setting of imminent disaster, it is a good idea to get one’s affairs in order. Autophagy, the process of recycling organelles and protein aggregates, is a basal homeostatic process and an evolutionarily conserved response to starvation and other forms of metabolic stress. Our understanding of the role of autophagy in the heart is changing rapidly as new information becomes available. This review examines the role of autophagy in the heart in the setting of cardioprotection, hypertrophy, and heart failure. Contradictory findings are reconciled in light of recent developments. The preponderance of evidence favors a beneficial role for autophagy in the heart under most conditions

Fostering Giftedness and Creativity: Implementing Engineering by Design in Kuwait

The article offers information on a partnership between the International Technology & Engineering Educators Association (ITEEA) and the Sabah Al Ahmad Center for Giftedness and Creativity (SACGC) to support innovation and design education. The partnership is aimed towards the implementation of the Engineering byDesign (EbD) curriculum and contribute towards building a Kuwaiti society that fosters giftedness and creativity

La Place et le rôle des femmes dans les Églises réformées

La diversité des informations concernant la condition de la femme protestante aux XVIe et XVIIe siècles explique que leur interprétation est complexe. Des historiens ont commencé par accentuer les effets positifs de la Réforme sur la condition féminine. Ensuite, les études ont conduit à des conclusions plus nuancées. Les hommes qui ont dirigé la Réforme paraissent en effet avoir contribué à renforcer le patriarcat familial et une hiérarchie sociale très fortement attestée. Nos recherches, qui ont porté sur un grand nombre de registres de consistoires des Églises locales, conduisent à penser que les efforts des Églises réformées et de leurs consistoires pour placer la femme sous l’autorité masculine furent largement suivis d’effets. Mais il apparaît aussi, que du fait des conditions d’existence des protestants français, les femmes ont trouvé à créer, puis à garder pour elles-mêmes un « espace » dans lequel elles tinrent un rôle de premier plan. Les nouvelles conceptions du mariage et certains usages ecclésiastiques ont en effet permis aux femmes réformées de conserver la capacité de se comporter avec une force et une indépendance qui, souvent, renvoie à des situations antérieures à la Réforme.The various interpretations surrounding the condition of Protestant women during the sixteenth and seventeenth centuries are diverse and complex. Historians initially emphasized the positive aspects of the Reformation on the role and status of women. Subsequent studies have been far more cautious in their conclusions. The men who led the Reformation seem to have worked for the reinforcement of patriarchy and the strengthening of a rigid social hierarchy. My own research, which is based on the examination of a substantial number of consistory registers from local churches, suggests that the efforts of the French Reformed Churches and their consistories were vigorous and effective. But it also appears that many Protestant women were able to establish and maintain their own feminine “space,” one which they dominated. The Protestant reconceptualization of marriage and certain ecclesiastical practices, for example, allo-wed Protestant women to retain the capacity to act with a force and independence that often recalled the situation prior to the Reformation.La diversidad de las informaciones sobre la condición de la mujer protestante en los siglos XVI y XVII iniplica una interpretación compleja. Distintos historiadores empezaron resaltando los efectos positivos de la Reforma sobre la condición feminina. Después, los estudios llegaron a conclusiones más matizadas. En efecto, parece que los hombres que condujeron la Reforma contribuyeron a fortalecer el pratiarcado familiar y una jerarquía social muy marcada. A partir del estudio de numerosos registros de consistorios de iglesias locales, nuestras investigaciones permiten pensar que los esfuerzos de las Iglesias reformadas y de sus consistorios para colocar a la mujer bajo la autoridad. masculina tuvieron muchos efectos en la realidad. Sin embargoo, se desprende también de nuestro estudio que, por las condiciones de vida de los protestantes franceses, las mujeres pudieron crear y conservar un « espaclo » propio donde tuvîeron un papel de primer importancia. En efecto, las nuevas concepciones del matrimonio y algunos usos eclesiásticos permitieron a las mujeres reformadas mantener la capacidad de comportarse cou una fuerza y una independencia que, frecuentemente, es comparable a situaciones anteriores a la Reforma

Myocardial hypothermia increases autophagic flux, mitochondrial mass and myocardial function after ischemia-reperfusion injury.

Animal studies have demonstrated beneficial effects of therapeutic hypothermia on myocardial function, yet exact mechanisms remain unclear. Impaired autophagy leads to heart failure and mitophagy is important for mitigating ischemia/reperfusion injury. This study aims to investigate whether the beneficial effects of therapeutic hypothermia are due to preserved autophagy and mitophagy. Under general anesthesia, the left anterior descending coronary artery of 19 female farm pigs was occluded for 90 minutes with consecutive reperfusion. 30 minutes after reperfusion, we performed pericardial irrigation with warm or cold saline for 60 minutes. Myocardial tissue analysis was performed one and four weeks after infarction. Therapeutic hypothermia induced a significant increase in autophagic flux, mitophagy, mitochondrial mass and function in the myocardium after infarction. Cell stress, apoptosis, inflammation as well as fibrosis were reduced, with significant preservation of systolic and diastolic function four weeks post infarction. We found similar biochemical changes in human samples undergoing open chest surgery under hypothermic conditions when compared to the warm. These results suggest that autophagic flux and mitophagy are important mechanisms implicated in cardiomyocyte recovery after myocardial infarction under hypothermic conditions. New therapeutic strategies targeting these pathways directly could lead to improvements in prevention of heart failure

Risk factors for breast cancer in a population with high incidence rates.

BackgroundThis report examines generally recognized breast cancer risk factors and years of residence in Marin County, California, an area with high breast cancer incidence and mortality rates.MethodsEligible women who were residents of Marin County diagnosed with breast cancer in 1997-99 and women without breast cancer obtained through random digit dialing, frequency-matched by cases' age at diagnosis and ethnicity, participated in either full in-person or abbreviated telephone interviews.ResultsIn multivariate analyses, 285 cases were statistically significantly more likely than 286 controls to report being premenopausal, never to have used birth control pills, a lower highest lifetime body mass index, four or more mammograms in 1990-94, beginning drinking after the age of 21, on average drinking two or more drinks per day, the highest quartile of pack-years of cigarette smoking and having been raised in an organized religion. Cases and controls did not significantly differ with regard to having a first-degree relative with breast cancer, a history of benign breast biopsy, previous radiation treatment, age at menarche, parity, use of hormone replacement therapy, age of first living in Marin County, or total years lived in Marin County. Results for several factors differed for women aged under 50 years or 50 years and over.ConclusionsDespite similar distributions of several known breast cancer risk factors, case-control differences in alcohol consumption suggest that risk in this high-risk population might be modifiable. Intensive study of this or other areas of similarly high incidence might reveal other important risk factors proximate to diagnosis

Evidence for adult lung growth in humans

A 33-year-old woman underwent a right-sided pneumonectomy in 1995 for treatment of a lung adenocarcinoma. As expected, there was an abrupt decrease in her vital capacity, but unexpectedly, it increased during the subsequent 15 years. Serial computed tomographic (CT) scans showed progressive enlargement of the remaining left lung and an increase in tissue density. Magnetic resonance imaging (MRI) with the use of hyperpolarized helium-3 gas showed overall acinar-airway dimensions that were consistent with an increase in the alveolar number rather than the enlargement of existing alveoli, but the alveoli in the growing lung were shallower than in normal lungs. This study provides evidence that new lung growth can occur in an adult human

Autophagy Induced by Ischemic Preconditioning is Essential for Cardioprotection

Based on growing evidence linking autophagy to preconditioning, we tested the hypothesis that autophagy is necessary for cardioprotection conferred by ischemic preconditioning (IPC). We induced IPC with three cycles of 5 min regional ischemia alternating with 5 min reperfusion and assessed the induction of autophagy in mCherry-LC3 transgenic mice by imaging of fluorescent autophagosomes in cryosections. We found a rapid and significant increase in the number of autophagosomes in the risk zone of the preconditioned hearts. In Langendorff-perfused hearts subjected to an IPC protocol of 3 × 5 min ischemia, we also observed an increase in autophagy within 10 min, as assessed by Western blotting for p62 and cadaverine dye binding. To establish the role of autophagy in IPC cardioprotection, we inhibited autophagy with Tat-ATG5K130R, a dominant negative mutation of the autophagy protein Atg5. Cardioprotection by IPC was reduced in rat hearts perfused with recombinant Tat-ATG5K130R. To extend the potential significance of autophagy in cardioprotection, we also assessed three structurally unrelated cardioprotective agents—UTP, diazoxide, and ranolazine—for their ability to induce autophagy in HL-1 cells. We found that all three agents induced autophagy; inhibition of autophagy abolished their protective effect. Taken together, these findings establish autophagy as an end-effector in ischemic and pharmacologic preconditioning

Detection of Murine Post-Pneumonectomy Lung Regeneration by 18FDG PET Imaging

Background: An intriguing biologic process in most adult mammals is post-pneumonectomy lung regeneration, that is, the removal of one lung (pneumonectomy) results in the rapid compensatory growth of the remaining lung. The spatial dependence and metabolic activity of the rodent lung during compensatory lung regeneration is largely unknown. Methods: To determine if murine lung regeneration could be detected in vivo, we studied inbred mice 3, 7, 14, and 21 days after left pneumonectomy. The remaining lung was imaged using microCT as well as the glucose tracer 2-deoxy-2-[18 F]fluoro-d-glucose (18FDG) and positron-emission tomography (PET). Because of the compliance of the murine chest wall, reproducible imaging required orotracheal intubation and pressure-controlled ventilation during scanning. Results: After left pneumonectomy, the right lung progressively enlarged over the first 3 weeks. The cardiac lobe demonstrated the greatest percentage increase in size. Dry weights of the individual lobes largely mirrored the increase in lung volume. PET/CT imaging was used to identify enhanced metabolic activity within the individual lobes. In the cardiac lobe, 18FDG uptake was significantly increased in the day 14 cardiac lobe relative to preoperative values (p < .05). In contrast, the 18FDG uptake in the other three lobes was not statistically significant at any time point. Conclusions: We conclude that the cardiac lobe is the dominant contributor to compensatory growth after murine pneumonectomy. Further, PET/CT scanning can detect both the volumetric increase and the metabolic changes associated with the regenerative growth in the murine cardiac lobe